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The Khc73 stalk/14-3-3 (show YWHAZ Proteins)/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
role of 14-3-3epsilon in germ cell migration
14-3-3epsilon acts as a biochemical control point for axon guidance in Drosophila, silencing Plexin A repulsive axon guidance and regulating a semaphorin repulsion/integrin adhesion switch.
We conclude that 14-3-3epsilon is required for Rab11 (show RAB11A Proteins)-positive vesicle function, which in turn enables antimicrobial peptide (show cAMP Proteins) secretion during an innate immune response.
Hpo (show GFER Proteins) signaling inhibited Yki (show YAP1 Proteins) nuclear localization and activity by phosphorylating Yki (show YAP1 Proteins) and both isoforms of 14-3-3 (show YWHAZ Proteins), 14-3-3varepsilon and 14-3-3zeta (show YWHAZ Proteins), regulate Yki (show YAP1 Proteins) activity through modulating its subcellular localization.
Drosophila 14-3-3/PAR-5 (show YWHAZ Proteins) is an essential mediator of PAR-1 (show F2R Proteins) function in axis formation.
PAR-1 (show F2R Proteins) phosphorylates Bazooka/PAR-3 (show PARD3 Proteins) on two conserved serines to generate 14-3-3 (show YWHAZ Proteins) binding sites. This inhibits formation of the Bazooka (show PARD3 Proteins)/PAR-6 (show PARD6A Proteins)/aPKC complex by blocking Bazooka (show PARD3 Proteins) oligomerization and binding to aPKC.
Serves as a central modulator of forkhead transcription factor FoxO activity in the regulation of growth, cell death and longevity in vivo.
The expression of epsilon isoforms of 14-3-3 protein was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.
YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B (show CDC25B Proteins) and MYC (show MYC Proteins) in gastric cancer cells.
we report recurrent BCOR (show BCOR Proteins) exon 16 internal tandem duplications and YWHAE-NUTM2B fusions in half of infantile soft tissue undifferentiated round cell sarcoma and most primitive myxoid mesenchymal tumor of infancy cases, but not in other pediatric sarcomas.
For metastatic YWHAE-rearranged HG-ESS, prolonged disease control following diagnosis was seen, with notable responses to anthracycline-based therapy. This emphasizes the need for appropriate molecular testing of uterine mesenchymal malignancies.
phosphorus NMR and time-resolved tryptophan fluorescence measurements suggest that 14-3-3zeta (show YWHAZ Proteins) interacts with the kinase domain of ASK1 (show MAP3K5 Proteins) in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation.
The 14-3-3 (show YWHAQ Proteins) family is dysregulated in schizophrenia, perhaps owing to specific regulatory mechanisms; the expression of the 14-3-3 epsilon, theta and zeta isoforms could be useful indicators of disease severity.
Studies show that patients with clear cell sarcoma of the kidney (CCSK) and the fusion YWHAE-NUTM2B/E were relatively young, had low tumor volumes, and did not present with stage I disease which fail to identify an explicit clinical phenotype.
Data show that the NS3 protein of dengue virus bound to 14-3-3 epsilon protein (14-3-3varepsilon) and prevented translocation of retinoic acid-inducible gene-I protein (RIG-I (show DDX58 Proteins)) to the adaptor MAVS (show MAVS Proteins) protein and thereby blocked antiviral signaling.
Report mutually exclusive BCOR (show BCOR Proteins) internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney.
CEP131 is the key regulatory target of MK2 (show KCNA2 Proteins) and 14-3-3 (show YWHAQ Proteins) in centriolar satellite remodeling.
14-3-3epsilon might directly bind to CD13 (show ANPEP Proteins), which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.
The complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors in mice.
The data obtained from the 14-3-3epsilon/14-3-3zeta (show YWHAZ Proteins)/Wnt1 (show WNT1 Proteins)-Cre mice strongly indicate the importance of 14-3-3 (show YWHAQ Proteins) proteins in the development of melanocyte lineages.
Data indicate that 14-3-3epsilon is required for the mitotic entry in the fertilized mouse eggs and responsible for sequestering the CDC25B (show CDC25B Proteins) in cytoplasm. Its binding to CDC25B (show CDC25B Proteins)-S321 phosphorylated by PKA induces mitotic arrest.
Ser321 of Cdc25B is the specific binding site for 14-3-3epsilon binding.
14-3-3epsilon deletion did not appear to induce compensation by other 14-3-3 (show YWHAQ Proteins) isoforms but led to ventricular noncompaction, resulting from a selective reduction in compact myocardium thickness.
14-3-3epsilon haploinsufficiency decreased the incorporation of expanded ATXN1 (show ATXN1 Proteins) into its large toxic complexes in the cerebellum but not in the brainstem, and the distribution of ATXN1 (show ATXN1 Proteins)'s small and large native complexes differed significantly between two regions
14-3-3 epsilon belongs to a regulatory protein family involved in important cellular processes, including those leading to neurodegenerative diseases, and thus its increased expression suggests a role of this protein in tuning microglia activation
The finding of this study suggested that dysfunction of the TH neuronal network caused by the deficit of 14-3-3 epsilon may have been involved in the pathophysiology of schizophrenia and correlated with a dysfunction in the DISC1 (show DISC1 Proteins) complex.
14-3-3epsilon interacts directly with PDX-1 (show PDX1 Proteins) to regulate its cellular distribution in pancreatic beta cells.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
, suppressor of Ras85D 3-9
, 14-3-3 epsilon
, 14-3-3 epsilon protein
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide
, 14-3-3 protein epsilon
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
, mitochondrial import stimulation factor L subunit
, protein kinase C inhibitor protein-1
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide
, MSF L
, mitochondrial import stimulation factor (MSF) L subunit
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide
, 14-3-3 protein