Areas: , ,

BLOOD: KLH-antibody in current publication

trafficking is strongly impaired in a for adhesion deficiency II but homing in the spleen is still normal, as Sviatlana Yakubenia from the Max Planck Institute for Molecular Biomedicine in Munster, Germany discovered together with colleagues from other German science institutions. Note: The scientists used this anti-KLH antibody among other antibodies for their research: anti-KLH antibody (ABIN129511).

adhesion deficiency II (LAD II) is a rare hereditary disease, characterised by the lack of fucosylated structures like selectin ligands. Fucose is a monosaccharide, responsible for cell-to-cell communication. In LAD II, a defective GDP-fucose transporter leads to developmental problems and deficiencies which are a result of the lacking fucosylated selektin ligands.

The scientists investigated LAD II in Slc35c1 -/- mice. , , and dependent rolling, which precedes migration through the to the site of , did not take place in those . The also did hardly stick to the .

The literature describes the dependent antibody reaction against bacteriophage PhiX174 and () as being normal in LAD II which suggests that and function is not impaired. is a copper containing oxygen transporter serving the same purpose in many molluscs and arthropods that does in vertebrates.

The scientists discovered that differentiation is reduced to 1-2% in the lymph nodes but is still normal in the spleen. Slc35c1 -/- mice thus show strong deficiencies in migration but normal antigen presentation in the spleen which may explain the normal function observed in LAD II.

Anti-KLH-antibody used in this publication:

anti-KLH antibody (ABIN129511)

Related antibodies on



Antibodies for the research area immunology:

Antibodies for the research area inflammation:

Antibodies for the research area tags/labels:

Antibodies against Mus musculus: