Circulation: Connection between ancient protein of cold shock family and cardiovascular disease

In a recent study published in the Journal “Circulation”, scientists from the University Hospital Aachen (Germany) demonstrate the relevance of a cold shock protein for the development of cardiovascular disease. The novelty of the in vitro and in vivo studies relates to the functional role of in the transcriptional regulation of chemokine in smooth muscle cells.

According to the results by the groups from Professor Christian Weber (Institute for Molecular Cardiovascular Research) and Professor Peter R. Mertens (Department of Nephrology and Clinical Immunology) the chemokine RANTES takes a lead role in atherogenesis and neointimal hyperplasia formation. By knocking-down the expression of the prototypic cold shock protein, , with short hairpin RNA the development of neointima and media formation was significantly reduced in an experimental mouse model. The authors demonstrate that is a crucial regulator of synthesis and neointima formation. The results raise the possibility to design a novel therapeutic intervention for the prevention of vascular lesion formation (vascular remodelling) in the future.

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