Areas: ,

NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins

2 and 3, two cytoplasmic scaffolding proteins hinder activation. are activated by () and costimulatory receptor () signals. This process is inhibited by binding of () and by competing with .

The active serine-threonine kinase counteracts against the - binding. The kinase enhances signalling by dephosphorylating in a -dependent reaction.

-deficient mice developed autoimmune-like pathology. Their expression was altered and their effector-memory populations elevated.

Related antibodies on antibodies-online.com:

Antibodies for the research area immunology:

Antibodies for the research area signalling:

Source: Guo N. Huang et al.: NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer Proteins, Science 319, 476 - 481 (25. Januar 2008)