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Recognition of an Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8+ T Lymphocytes

A rising response with reactivity to a -derived peptide was found in a screen for endogenous tumour-associated responses in a primary mouse model of .

Although histones are omnipresent in the body, the recognition of the histone peptide could be specifically linked to the of these mice.It seems as if the antigen repertoire that can be recognised by tumour-infiltrating is broader than previously thought. Apparently even peptides derived from ubiquitous self-antigens are amongst those that are normally not detected by the immune system.

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