Areas: , ,

Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice

(), a cytokine associated with inflammation and autoimmunity, may promote autoimmune disease through another mechanism than its proinflammatory effects. Autoimmune BXD2 mice have a stronger expression of and spontaneously develop germinal centers (GCs) before an increase in production of pathogenic autoantibodies occurs.

Blocking signalling cleaves the and interactions that are necessary for the formation of GCs. Mice lacking the receptor show reduced GC development and humoral responses.

When is produced increased expression of the genes Rgs13 and Rgs16 may be observed. The genes encode for regulators of signalling. The result is suppression of the chemotactic response to the CXCL12. Apparently, drives autoimmune responses by promoting the formation of spontaneous GCs.

Related antibodies on

IL-17-Receptor B

IL-17-Receptor D


Antibodies for the research area chemokines:

Antibodies for the research area cytokines:

Antibodies for the research area immunology: