CD160 inhibits activation of human CD4+ T cells through interaction with herpes virus entry mediator

expression increases if human are activated. Crosslinking of with a monoclonal antibody inhibits - and CD28-mediated T cell activation. is a member of the immunoglobulin superfamily and is expressed in cytolytic lymphocytes as well as in some unstimulated .

The () is a ligand of and functions as a 'bidirectional switch' for activation. Whether the result is positive or negative depends on the engagement of by and other established ligands like () or the receptor .

activation in -transfected cells was dependent on and . By deletion of the cysteine-rich domain 1 of the inhibition is lost and were activated. seems to be a negative regulator of activation through its interaction with .

Related antibodies on

CD3 T-cell

Antibodies for the research area immunology: