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An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

The essential bacterial guanosine triphosphatase FtsZ was validated as a target for antibacterial intervention by British researchers from Prolysis in Oxfordshire and the University of Sheffield. FtsZ is a bacterial homologue of mammalian that initiates cell division by polymerising and then assembling into a ring.

The substance PC190723 prevents cell division and was used as inhibitor of FtsZ. It showed potent and selective bactericidal activity against staphylococci in vitro, including methicillin- and multi-drug–resistant strains of and succeeded in curing mice infected with a lethal dose of in an in vivo model of infection.
The putative inhibitor-binding site of PC190723 could be mapped to a region of FtsZ that is analogous to the Taxol-binding site of .

Related antibodies on


Staphylococcus aureus (methicillin resistant)

Antibodies for the research area bacteria:

Antibodies for the research area cell cycle:

Antibodies for the research area drugs: