A reliable LPS screening of materials that come into contact with whole organisms or cultured cells is therefore essential. Traditionally, the Limulus amoebocyte lysate (LAL) assay has been used for this purpose. The major shortcoming of this method - besides the use of blood from an endangered population of horseshoe crabs - is the sensitivity of the assay to possible unspecific reactions to other components of the heterogeneous samples.
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Selected References for ABIN1169646
Feng, Wang, Zhang, Gao, Tao, Ge, Zhu, Bi: "Modulation of gut microbiota contributes to curcumin-mediated attenuation of hepatic steatosis in rats." in: Biochimica et biophysica acta, Vol. 1861, Issue 7, pp. 1801-1812, 2017
Rosas-Villegas, Sánchez-Tapia, Avila-Nava, Ramírez, Tovar, Torres: "Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress." in: Nutrients, Vol. 9, Issue 4, 2017
Sánchez-Tapia, Aguilar-López, Pérez-Cruz, Pichardo-Ontiveros, Wang, Donovan, Tovar, Torres: "Nopal (Opuntia ficus indica) protects from metabolic endotoxemia by modifying gut microbiota in obese rats fed high fat/sucrose diet." in: Scientific reports, Vol. 7, Issue 1, pp. 4716, 2017
Hartmann, Seebauer, Mazagova, Horvath, Wang, Llorente, Varki, Brandl, Ho, Schnabl: "Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 310, Issue 5, pp. G310-22, 2016
Wosiewicz, Żorniak, Hartleb, Barański, Hartleb, Onyszczuk, Pilch-Kowalczyk, Kyrcz-Krzemień: "Portal vein thrombosis in cirrhosis is not associated with intestinal barrier disruption or increased platelet aggregability." in: Clinics and research in hepatology and gastroenterology, 2016
Gao, Wen, Tong, Wang, Yang, Tang, Yan, Tai, Ye, Liu, Huang, Tang, Yang, Tang: "Inhibition of cyclooxygenase-2 alleviates liver cirrhosis via improvement of the dysfunctional gut-liver axis in rats." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 310, Issue 11, pp. G962-72, 2016