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The Deubiquitinating Enzyme A (DUBA) turns out to be a negative regulator of innate immune responses. A recent study conducted by N. Kayagaki from the biotech business firm Genentech (USA) discovered the deubiquitinating enzyme with the ovarian tumor domain as regulator of IFN type 1 production, which is a crucial host defense, caused by pattern-recognition receptors (PRRs) of the innate immune system.
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The cell response to -damage is manipulated by phosphorylation of and the ligase. N. K. Kolas, J. R. Chapman and S. Nakada from the Samuel Lunenfeld Research Institute in Canada and from the University of Cambridge (UK) discovered that is responsible for conjugation and the accumulation of and at locations of -damage.