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Human CD40 Ligand Protein expressed in CHO Cells - ABIN1344289
Holler, Tardivel, Kovacsovics-Bankowski, Hertig, Gaide, Martinon, Tinel, Deperthes, Calderara, Schulthess, Engel, Schneider, Tschopp: Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. in Molecular and cellular biology 2003
Show all 3 Pubmed References
Human CD40 Ligand Protein expressed in CHO Cells - ABIN1344285
Guarda, Dostert, Staehli, Cabalzar, Castillo, Tardivel, Schneider, Tschopp: T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. in Nature 2009
Show all 2 Pubmed References
specific cross-linking with trimeric recombinant HIV-1 gp140 revealed reduced sensitivity for inhibition of CD154 up-regulation in chimpanzees, requiring fourfold higher concentrations of viral protein
identification and functional characterization of CD40L and CD40 (show CD40 Proteins) from Atlantic salmon (Salmo salar); results provide evidence for the existence of a functional CD40L mediated costimulatory pathway in Atlantic salmon
the CD40 (show CD40 Proteins) rs1883832 T allele acts as a risk factor for increased susceptibility to sepsis and may be involved in the process of sepsis through regulation of CD40 (show CD40 Proteins) expression and plasma sCD40L levels.
Overexpression of CD40L-WT/CD40L-M in CD40 (show CD40 Proteins)+ NSCLC cells increased SA-beta-gal (show GLB1 Proteins) staining activity and inhibited DNA synthesis and cell proliferation.
T cell-stimulated CLL cells actively recruited monocytes, and CD40L was identified as the responsible T-cell factor that mediated recruitment.
this study shows that decreased serum levels of soluble CD40L correlate in treated patients with Relapsing-Remitting Multiple Sclerosis
In this first X chromosome-wide association study of adult patients with IBD, we identified an IBD susceptibility locus with genome-wide significance at rs2427870 on chrXq26.3, located 66 kbp upstream of CD40LG and 83.4 kbp upstream of ARHGEF6 [OR, 1.22; combined p = 3.79 x 10-15].
Study indicates that the rs1126535C/T polymorphism of CD154 gene was involved in the progression of Chinese SLE patients, probably by affecting the expression of CD154.
study found that plasma CD40L was associated with acute chest syndrome (ACS), and that sickle cell anemia (SCA)patients with a lifetime history of ACS (ACS+) presented significantly higher plasma CD40L and TSP-1 than patients who had never experienced ACS (ACS-)
this paper demonstrates importance of CD40 (show CD40 Proteins)/CD40L signaling on IL-10 (show IL10 Proteins)-producing regulatory B cells in Chinese children with Henoch-Schonlein purpura nephritis
Soluble CD40 ligand derived from serum is not correlated with early stage of multiple sclerosis.
Analysis of the early events after receptor engagement revealed that both TNF (show TNF Proteins) and CD40L activate the classical NF-kappaB (show NFKB1 Proteins) pathway, and confirm activation of the alternative by the latter. Furthermore, using genetic and pharmacological inhibition of the classical pathway we show that activation of the alternative occurs independently of the former. This reveals insights into NF-kappaB (show NFKB1 Proteins) signaling by CD40L and TNF (show TNF Proteins) in endoth...
MR1 (show MR1 Proteins)-induced bone accrual was associated with increased Treg development and elevated production of cytotoxic T lymphocyte antigen 4 (show CTLA4 Proteins), a costimulation inhibitor that promotes T cell anergy and CD8 (show CD8A Proteins)+ T cell expression of the bone anabolic ligand Wnt (show WNT2 Proteins)-10b.
These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.
Soluble CD40 ligand directly alters glomerular permeability and may act as a circulating permeability factor in focal segmental glomerulosclerosis.
studies identify a novel molecular mechanism of regulation of CD40L by the transcription factor GLI2 in the tumor microenvironment downstream of CCR3 (show CCR3 Proteins) signaling
our results unambiguously demonstrate that while CD40L is critical to generate effective primary CD8 (show CD8A Proteins)(+) T-cell responses also under inflammatory conditions, CD40L expression by CD8 (show CD8A Proteins)(+) T cells themselves is dispensable in acute lymphocytic choriomeningitis virus infection.
Platelets promote allergic asthma through the expression of CD154.
CD40L does not play a functional role in experimental acute pancreatitis
The tissue-specific, activation-dependent and reversible expression of CD40L fully mimics the physiological induction and disappearance of the molecule from the surface of murine T lymphocytes.
there is a major involvement of the CD40 (show CD40 Proteins)-CD40L signaling pathway in long-term brain dysfunction in an animal model of sepsis.
Report targeting and liposomal drug delivery of methotrexate to CD40L expressing T cells for treatment of autoimmune diseases.
CD40 ligand has a role in inducing endothelial dysfunction in human and porcine coronary artery endothelial cells
Results demonstrated greater CD40 (show CD40 Proteins) and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease.
Both two-trimer and four-trimer forms of macaque CD40L were active in B-cell proliferation assays using macaque and human cells.
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)
, CD40 ligand
, TNF superfamily member 5
, CD40 antigen ligand
, T-B cell-activating molecule
, T-cell antigen Gp39
, TNF-related activation protein
, tumor necrosis factor (ligand) superfamily member 5
, tumor necrosis factor ligand superfamily member 5
, CD40 ligand CD154
, tumor necrosis factor (ligand) superfamily, member 5
, human : hyper-IgM syndrome
, uncharacterized protein LOC100358388
, putative CD154 (CD40 ligand)
, CD154 protein