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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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1 | ABIN1585686 | IHC ELISA WB | Rabbit | Middle Region | Log in to see | Polyclonal | 0 |
General |
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Antigen | Growth Hormone Receptor (GHR) Antibodies |
Epitope | C-Term Alternatives |
Reactivity | Dog (Canine), Horse (Equine), Human, Pig (Porcine) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This Growth Hormone Receptor antibody is un-conjugated Alternatives |
Application |
Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-Growth Hormone Receptor AntibodyTarget Details Growth Hormone Receptor Application Details Handling Images |
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Blocking Peptide | Blocking peptide for this product available: ABIN2181981 |
Sequence | YSLKVDKEYE VRVRSKQRNS GNYGEFSEVL YVTLPQMSQF TCEEDFYFPW |
Predicted Reactivity | Dog: 79%, Horse: 79%, Human: 100%, Pig: 79% |
Characteristics | This is a rabbit polyclonal antibody against GHR. It was validated on Western Blot. |
Purification | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the C-terminal region of Human GHR |
Target Details Growth Hormone ReceptorProduct Details anti-Growth Hormone Receptor Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | GHR (GHR Antibody Abstract) |
Background |
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Alias Symbols: GHBP Protein Interaction Partner: FBXW11, JAK2, GHR, GH1, BTRC, UBC, SKP1, SOCS2, STUB1, PTPRH, PTPRB, PTPN13, PTPN9, PTPN3, PTPN2, PTPN1, DUSP7, NCOA6, STAT5B, SOCS3, SOCS1, SGTA, CISH, GRB10, STAT5A, AP2A1, SHC1, TYK2, PTPN6, PTPN11, PRLR, PIK3R1, JAK1, IRS1, GH2, GRB2, STAT3, PLCG1, Protein Size: 294 |
Molecular Weight | 32 kDa |
Gene ID | 2690 |
NCBI Accession | NM_001242462, NP_001229391 |
Pathways | NF-kappaB Signaling, JAK-STAT Signaling, Response to Growth Hormone Stimulus |
Application DetailsProduct Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Handling Images back to top |
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Restrictions | For Research Use only |
HandlingProduct Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Application Details Images back to top |
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Format | Liquid |
Concentration | 1 mg/mL |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeat freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
ImagesProduct Details anti-Growth Hormone Receptor Antibody Target Details Growth Hormone Receptor Application Details Handling back to top |
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Supplier Images |