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anti-Human IL1RAP Antibodies:
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Human Polyclonal IL1RAP Primary Antibody for CyTOF, FACS - ABIN4899586
Michaud, Al-Akoum, Akoum: Blood soluble interleukin 1 receptor accessory protein levels are consistently low throughout the menstrual cycle of women with endometriosis. in Reproductive biology and endocrinology : RB&E 2014
Show all 3 Pubmed References
Human Polyclonal IL1RAP Primary Antibody for FACS, WB - ABIN4899584
Barreyro, Will, Bartholdy, Zhou, Todorova, Stanley, Ben-Neriah, Montagna, Parekh, Pellagatti, Boultwood, Paietta, Ketterling, Cripe, Fernandez, Greenberg, Tallman, Steidl, Mitsiades, Verma, Steidl: Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. in Blood 2012
Show all 2 Pubmed References
Human Polyclonal IL1RAP Primary Antibody for ELISA - ABIN2682161
Southcombe, Redman, Sargent, Granne: Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia. in Clinical and experimental immunology 2015
Human Monoclonal IL1RAP Primary Antibody for FACS - ABIN4896354
Bianchetti, Marini, Isgrò, Bellini, Schmidt, Mattoli: IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma. in Biochemical and biophysical research communications 2012
Human Monoclonal IL1RAP Primary Antibody for CyTOF, FACS - ABIN4899585
Warda, Larosa, Neto Da Rocha, Trad, Deconinck, Fajloun, Faure, Caillot, Moldovan, Valmary-Degano, Biichle, Daguindau, Garnache-Ottou, Tabruyn, Adotevi, Deschamps, Ferrand: CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor-Engineered T Cells. in Cancer research 2019
IL1B regulates expression of IL1R1 and IL1RAP and stimulates expression of PTGS1 and PTGS2 that are considered to be the most rate-limiting enzymes for endometrial synthesis of prostaglandins during the peri-implantation period of pregnancy in pigs.
Expression level of sIL1RAP may become one of the potential indexes for determining the prognosis of low-grade gliomas
Reconstitution of ST2 (IL-1R4) specific for IL-33 activity; no suppression by IL-1Ra though a common chain IL-1R3 (IL-1RAcP) shared with IL-1.
These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells.
single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP.
The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework.
The SNP rs4624606 in IL-1RAcP was nominally associated with CAD risk.
Data suggest serum levels of soluble IL1RAP (from alternative splicing) are down-regulated in endometriosis throughout menstrual cycle; IL1RAP levels (which peak in proliferative phase in fertile women) exhibit minor variations in endometriosis.
Plasma sIL1RAP levels are reduced in obesity and can potentially act as biomarkers of obesity.
Combined crystallography and small-angle X-ray-scattering studies reveal that ST2 possesses hinge flexibility between the D3 domain and D1D2 module, whereas IL-1RAcP exhibits a rigid conformation in the unbound state in solution.
MARCH8-mediated polyubiquitination and degradation of IL1RAP is an important mechanism for negative regulation of IL-1beta-induced signaling pathways.
Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML cells.
Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase.
The genetic polymorphisms of IL-1ss-2023 C allele, IL- 1RAcP -8261 T allele and -8183 A allele are probable host factors for persistent HBV infection.
decreased protein levels in the peritoneal fluid of women with endometriosis
Studies indicate that new targets have recently been investigated as potential modulators in myeloid leukemia pathogenesis, including miR-328, BMI1, FOXOs and IL1RAP.
This study showed a significant downregulation of soluble interleukin-1 receptor accessory protein expression in the endometrium of women with endometriosis.
identifies IL1RAP as a unique cell surface biomarker distinguishing Ph(+) from Ph(-) candidate chronic myeloid leukemia (CML) stem cells and opens up a previously unexplored avenue for therapy of CML
Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling
soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor
The dramatic changes in levels of IL-1RAcP mRNAs suggest important functions in regulating sensitivity to IL-1 during stress and may play a role in oncogenic processes that are engaged during chronic inflammation.
These results thus reveal the decoding mechanism of splice-insert signaling codes for synaptic differentiation induced by trans-synaptic adhesion between PTPdelta and IL1RAPL1/IL-1RAcP.
We conclude that neuron-specific AcPb plays a critical role in host defenses and sleep homeostasis.
In experimental biliary atresia, miR-29a/29b1 are upregulated, and reporter assays confirmed that Igf1 and Il1RAP are down-regulated by miR-29.
The results of this study suggested that IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain.
IL-1RAcP is essential for physiological activities of peripheral IL-1.
determination of interaction sites in vitro mutagenesis and molecular modeling
data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 complex by binding to epitopes on domain III of the IL-1RI created following IL-1 binding to the IL-1RI
IL-33 and ST2 form a complex with IL-1R accessory protein (IL-1RAcP), a signaling receptor subunit that is also a member of the IL-1R complex.
IL-1RAcP is used by more than one alpha-chain of the IL-1 receptor family and thus may resemble a common beta-chain of that family
these observations establish AcP as co-receptor for IL-33 signaling via ST2 and suggest a novel role for sAcP in modulating the biological activity of IL-33
an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS.
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
interleukin 1 receptor accessory protein
, interleukin-1 receptor accessory protein
, interleukin-1 receptor accessory protein-like
, IL-1 receptor accessory protein
, interleukin-1 receptor 3
, interleukin-1 receptor accessory protein beta