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|Antigen||KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This KHDRBS1 antibody is conjugated to Alexa Fluor 488 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-KHDRBS1 AntibodyTarget Details KHDRBS1 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human SAM68|
Target Details KHDRBS1Product Details anti-KHDRBS1 Antibody Application Details Handling Images back to top
|Alternative Name||Sam68 (KHDRBS1 Antibody Abstract)|
Sam 68 is a protein that is phosphorylated on tyrosine and functions as a substrate for Src family tyrosine kinases during mitosis. Sam 68 also associates with several SH2 and SH3 domain-containing signaling proteins, such as GRB2 and PLC ?. Originally cloned as Ras GAP-associated p62, further investigations have shown that Sam 68 and Ras GAP-associated p62 are not antigenically related, nor are they encoded by the same gene. Like Sam 68, the Sam 68-like mammalian proteins, SLM-1 and SLM-2, demonstrate RNA binding activity. Also like Sam 68, SLM-1 is tyrosine phosphorylated and functions as an adapter protein for signaling molecules, including GRB2, PLC ?, Fyn and Ras GAP. SLM-2 is not tyrosine phosphorylated, nor does it appear to associate with GRB2, PLC ?, Fyn or Ras GAP, indicating that SLM-2 may not be an adapter protein for these proteins.
Synonyms: FLJ34027, GAP associated tyrosine phosphoprotein p62, GAP-associated tyrosine phosphoprotein p62, KH domain containing RNA binding signal transduction associated 1, KH domain-containing, KHDR1_HUMAN, KHDRBS1, p21 Ras GTPase activating protein associated p62, p21 Ras GTPase-activating protein-associated p62, p62, p68, RNA-binding, Sam68, signal transduction-associated protein 1, Src associated in mitosis 68 kDa protein, Src-associated in mitosis 68 kDa protein.
|Research Area||Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA|
|Pathways||NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy|
Application DetailsProduct Details anti-KHDRBS1 Antibody Target Details KHDRBS1 Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-KHDRBS1 Antibody Target Details KHDRBS1 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|