anti-Human MAP3K7 antibody for Dot Blot

Recommended MAP3K7 Antibody (supplied by: Log in to see )

Antigen
Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Antibodies
  • si:ch211-225h9.1
  • zgc:110612
  • Tak1
  • MEKK7
  • TAK1
  • TGF1a
  • B430101B05
  • C87327
  • mitogen-activated protein kinase kinase kinase 7
  • mitogen activated protein kinase kinase kinase 7
  • map3k7
  • Map3k7
  • MAP3K7
Epitope
pSer192
30
18
18
16
14
13
10
9
6
5
4
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
175
71
59
6
6
5
5
5
5
4
3
2
2
2
2
1
1
Host
Rabbit
151
13
13
Clonality
Polyclonal
Conjugate
This MAP3K7 antibody is un-conjugated
9
9
9
9
9
9
Application
Dot Blot (DB)
146
103
49
34
19
6
6
5
2
1
1
1
1
Options
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Catalog No. ABIN389742
$ 324.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
28.874563 ABIN389721 DB Rabbit Ig Fraction pThr187 Log in to see Polyclonal 0
1 ABIN358312 DB EIA Rabbit Ig Fraction pSer192 Log in to see Polyclonal 5
1 ABIN1955209 DB ELISA Biotin Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN1956108 DB ELISA WB FITC Rabbit IgG pSer192 Log in to see Polyclonal 0
1 ABIN1956385 DB ELISA FITC Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN1958435 DB ELISA WB PE Rabbit IgG pSer192 Log in to see Polyclonal 0
1 ABIN1953075 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN1953947 DB ELISA APC Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN1952790 DB ELISA WB Alkaline Phosphatase (AP) Rabbit IgG pSer192 Log in to see Polyclonal 0
1 ABIN1953662 DB ELISA WB APC Rabbit IgG pSer192 Log in to see Polyclonal 0
1 ABIN1954959 DB ELISA WB Biotin Rabbit IgG pSer192 Log in to see Polyclonal 0
1 ABIN2587046 DB Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN2587047 DB ELISA Rabbit IgG pSer192 Log in to see Polyclonal 0
1 ABIN2307052 DB Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN2307059 DB ELISA WB Rabbit IgG pSer192 Log in to see Polyclonal 0
1 ABIN1957332 DB ELISA WB HRP Rabbit IgG pSer192 Log in to see Polyclonal 0
1 ABIN1957588 DB ELISA HRP Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN2307057 DB ELISA HRP Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN2307056 DB ELISA FITC Rabbit IgG pThr187 Log in to see Polyclonal 0
1 ABIN2307054 DB ELISA APC Rabbit IgG pThr187 Log in to see Polyclonal 0

General

Antigen Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) Antibodies
Epitope pSer192
(30), (18), (18), (16), (14), (13), (10), (9), (6), (5), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(175), (71), (59), (6), (6), (5), (5), (5), (5), (4), (3), (2), (2), (2), (2), (1), (1)
Host Rabbit
(151), (13), (13)
Clonality (Clone)
Polyclonal   ( )
Conjugate This MAP3K7 antibody is un-conjugated
(9), (9), (9), (9), (9), (9)
Application Dot Blot (DB)
(146), (103), (49), (34), (19), (6), (6), (5), (2), (1), (1), (1), (1)
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Product Details anti-MAP3K7 Antibody

Target Details MAP3K7 Application Details Handling Images
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen This MAP3K7 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S192 of human MAP3K7.
Clone RB11313
Isotype Ig Fraction

Target Details MAP3K7

Product Details anti-MAP3K7 Antibody Application Details Handling Images back to top
Antigen
Alternative Name MAP3K7 (MAP3K7 Antibody Abstract)
Background Function
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2- induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

Cellular Location
Cytoplasm. Cell membrane, Peripheral membrane protein, Cytoplasmic side. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane

Tissue Location
Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form

Synonyms: Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, MAP3K7, TAK1,
Molecular Weight 67196 Da
Gene ID 6885
UniProt O43318
Pathways NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades

Application Details

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Handling Images back to top
Application Notes Suggested dilutions:
DB = 1:500
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Images back to top
Format Liquid
Concentration 0.491 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months

Images

Product Details anti-MAP3K7 Antibody Target Details MAP3K7 Application Details Handling back to top
Supplier Images
Dot Blot (DB) image for anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (pSer192) antibody (ABIN389742) Dot blot analysis of Phospho-MAP3K7-S192 polyclonal antibody (ABIN389742) on nitrocel...