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Human MAP3K7 Protein expressed in Wheat germ - ABIN1310225
Salazar, Kashiwada, Krejci, Meyer, Casale, Hallowell, Wilcox, Donoghue, Thompson: Fibroblast growth factor receptor 3 interacts with and activates TGF?-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer. in PLoS ONE 2014
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TGFbeta (show TGFB1 Proteins) and IL1beta (show IL1B Proteins) signaling interact at the SMAD2 (show SMAD2 Proteins)/3 level in human primary MSC (show MSC Proteins). Down-stream TGFbeta (show TGFB1 Proteins) target genes were repressed by IL1beta (show IL1B Proteins) independent of C-terminal SMAD2 (show SMAD2 Proteins) phosphorylation. We demonstrate that SMAD2 (show SMAD2 Proteins)/3 linker modifications are required for this interplay and identified TAK1 as a crucial mediator of IL1beta (show IL1B Proteins)-induced TGFbeta (show TGFB1 Proteins) signal modulation.
increased TAK1 expression may be involved in the progression of gastric cancer.
miR (show MLXIP Proteins)-146a, serving as a tumor suppressor, may significantly promote GC cell apoptosis by inhibition of the NF-kappaB (show NFKB1 Proteins) signaling pathway via targeting TAK1.
In conclusion, for the first time, we report that TRADD (show TRADD Proteins), TRAF2 (show TRAF2 Proteins), RIP1 (show UQCRFS1 Proteins) and TAK1 play a role in the regulating TNF-alpha (show TNF Proteins) signalling in human myometrium. These findings are of significance given the central role of TNF-alpha (show TNF Proteins) in the processes of human labour and delivery.
Rab1 (show RAB1A Proteins) is regulated by the host in a similar fashion, and that the innate immunity kinase TAK1 and Legionella effectors compete to regulate Rab1 (show RAB1A Proteins) by switch II modifications during infection.
nMet accelerated HCC (show FAM126A Proteins) tumorigenesis and metastasis via the activation of TAK1/NF-kappaB (show NFKB1 Proteins) pathway.
TAK1 protein expression increased in cartilage tissue from spinal tuberculosis patients.
TAK1 regulates Nrf2 (show GABPA Proteins) through modulation of Keap-p62/SQSTM1 (show SQSTM1 Proteins) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Overexpression of TAK1 was strongly associated with positive lymph node metastasis in pancreatic ductal adenocarcinoma.
dysregulation of the TAK1 complex produces a close phenocopy of Frontometaphyseal Dysplasia caused by FLNA (show FLNA Proteins) mutations; furthermore, the pathogenesis of some of the filaminopathies caused by FLNA (show FLNA Proteins) mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
Data indicate TNF receptor associated factor 6 (TRAF6 (show TRAF6 Proteins)) as an essential molecular switch leading to cardiac hypertrophy in a transforming growth factor beta-activated kinase 1 (TAK1), -dependent manner.
It is a key regulator of the toll (show TLR4 Proteins)-like receptor signaling pathway.
The conversion of Tak1 (show NR2C2 Proteins)-B to Tak1 (show NR2C2 Proteins)-A consistently led to significant accumulation of lipids in cultured AML12cells, as well as the dysregulation of several lipid metabolism-related genes in mouse liver. Different functional properties of the two isoforms may explain the conflicting functions previously reported for Tak1 (show NR2C2 Proteins).
demonstrate the efficiency of ad--siRNA-TAK1 (show NR2C2 Proteins) in controlling joint inflammation of Collagen-Induced Arthritis, which is associated with the suppression of the expression of pro-inflammatory cytokines and JNK (show MAPK8 Proteins) activation.
These data, in addition to the fact that Map3k7 is upregulated in the sinus venous-the source of cells for the SAN-suggest that Map3k7 may be an endogenous regulator of the SAN fate
These results present a novel in vivo function, the negative role of TAK1 (show NR2C2 Proteins) in marginal zone B-cell development that is likely associated with NF-kappaB2 activation.
Tnfr1 (show TNFRSF1A Proteins) deletion partially restored thymic and lung macrophages.
TAK1 (show NR2C2 Proteins) is required for PPARgamma (show PPARG Proteins) transactivation and promotes PPARgamma (show PPARG Proteins) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (show TAB1 Proteins)).
inhibition of TAK1 (show NR2C2 Proteins) triggered two caspase 8 (show CASP8 Proteins) activation pathways through the induction of RIP1 (show RALBP1 Proteins)-FADD (show FADD Proteins)-caspase 8 (show CASP8 Proteins) complex as well as FLIP cleavage/degradation.
Transforming growth factor-beta activated kinase 1 (TAK1) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (show FAM126A Proteins)) development.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1