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|Antigen||Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibodies|
|Epitope||AA 14-263 Alternatives|
|Reactivity||Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This MYD88 antibody is un-conjugated Alternatives|
Cell Culture (CC), Western Blotting (WB)
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Product Details anti-MYD88 AntibodyTarget Details MYD88 Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for MyD88 detection. Tested with WB, ELISA(Cap) in Mouse,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for MyD88 detection. Tested with WB, ELISA(Cap) in Mouse,Rat.
Gene Name: myeloid differentiation primary response 88
Protein Name: Myeloid differentiation primary response protein MyD88
|Purification||Immunogen affinity purified.|
|Immunogen||E. coli-derived rat MyD88 recombinant protein (Position: D14-D263).|
Target Details MYD88Product Details anti-MYD88 Antibody Application Details Handling Images back to top
|Alternative Name||Myd88 (MYD88 Antibody Abstract)|
MYD88(MYELOID DIFFERENTIATION PRIMARY RESPONSE GENE 88), is a protein that, in humans, is encoded by the MYD88 gene. MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL1Rs). And it is mapped on 3p22.2. MYD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. Overexpression of MYD88 caused an increase in the level of transcription from the interleukin-8 promoter. The C-terminal domain of MYD88 has significant sequence similarity to the cytoplasmic domain of IL1RAP. Inhibiting the IL1R-MYD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.
Synonyms: Myeloid differentiation primary response protein MyD88, Myd88
|Pathways||NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-MYD88 Antibody Target Details MYD88 Handling Images back to top
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details Images back to top
|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C,-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.