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|Antigen||Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibodies|
|Epitope||Middle Region Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This MYD88 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|2 references available|
|Supplier||Log in to see|
Product Details anti-MYD88 AntibodyTarget Details MYD88 Application Details Handling References for anti-MYD88 antibody (ABIN453754) Images
|Specificity||This antibody reacts to MYD88.|
|Purification||Affinity chromatography on Protein A|
|Immunogen||KLH conjugated synthetic peptide selected from the Center region of human MyD88|
Target Details MYD88Product Details anti-MYD88 Antibody Application Details Handling References for anti-MYD88 antibody (ABIN453754) Images back to top
|Alternative Name||MYD88 (MYD88 Antibody Abstract)|
|Background||Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. It acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and increases IL-8 transcription. It may be involved in myeloid differentiation.Synonyms: Myeloid differentiation primary response protein MyD88|
|Pathways||NF-kappaB Signaling, TLR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades|
Application DetailsProduct Details anti-MYD88 Antibody Target Details MYD88 Handling References for anti-MYD88 antibody (ABIN453754) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details References for anti-MYD88 antibody (ABIN453754) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-MYD88 antibody (ABIN453754)Product Details anti-MYD88 Antibody Target Details MYD88 Application Details Handling Images back to top
Bannon, Davies, Collett, Warhurst: "Potentiation of flagellin responses in gut epithelial cells by interferon-gamma is associated with STAT-independent regulation of MyD88 expression." in: The Biochemical journal, Vol. 423, Issue 1, pp. 119-28, 2009
Burns, Martinon, Esslinger, Pahl, Schneider, Bodmer, Di Marco, French, Tschopp: "MyD88, an adapter protein involved in interleukin-1 signaling." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12203-9, 1998
ImagesProduct Details anti-MYD88 Antibody Target Details MYD88 Application Details Handling References for anti-MYD88 antibody (ABIN453754) back to top