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|Antigen||Nerve Growth Factor Receptor (NGFR) Antibodies|
|Epitope||AA 287-337 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This NGFR antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
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Product Details anti-NGFR AntibodyTarget Details NGFR Application Details Handling References for anti-NGFR antibody (ABIN725660) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from rat NGFR|
Target Details NGFRProduct Details anti-NGFR Antibody Application Details Handling References for anti-NGFR antibody (ABIN725660) Images back to top
|Alternative Name||p75 NGF Receptor (NGFR Antibody Abstract)|
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Subcellular location: Cytoplasm
Synonyms: p75, LNGFR, p75NTR, RNNGFRR, Tnfrsf16, Tumor necrosis factor receptor superfamily member 16, Gp8-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, Ngfr
|Pathways||NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding|
Application DetailsProduct Details anti-NGFR Antibody Target Details NGFR Handling References for anti-NGFR antibody (ABIN725660) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-NGFR Antibody Target Details NGFR Application Details References for anti-NGFR antibody (ABIN725660) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-NGFR antibody (ABIN725660)Product Details anti-NGFR Antibody Target Details NGFR Application Details Handling Images back to top
|Product cited in:||
Śmieszek, Stręk, Kornicka, Grzesiak, Weiss, Marycz: "Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels-An Ex Vivo Study." in: International journal of molecular sciences, Vol. 18, Issue 4, 2017 Method employed by authors: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (fixed cells) (IF/ICC) (Sample species: Mouse (Murine)).
Zhang, Chen, Liu, Zhou, Hu, Zhou, Han, Chen: "Exendin-4 promotes proliferation of adipose-derived stem cells through ERK and JNK signaling pathways." in: In vitro cellular & developmental biology. Animal, Vol. 52, Issue 5, pp. 598-606, 2016
Paczkowska, Kaczy?ska, Pius-Sadowska, Rogi?ska, Kawa, Ustianowski, Safranow, Celewicz, Machali?ski: "Humoral activity of cord blood-derived stem/progenitor cells: implications for stem cell-based adjuvant therapy of neurodegenerative disorders." in: PLoS ONE, Vol. 8, Issue 12, pp. e83833, 2014 (Sample species: Human).
Shan, Zhou, Yang, Yan, Zhang, Fu, Jiang: "Lithium chloride promotes the odontoblast differentiation of hair follicle neural crest cells by activating Wnt/?-catenin signaling." in: Cell biology international, 2014 (Sample species: Mouse (Murine)).
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