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|Antigen||Protein Kinase A, alpha (PRKACA) Antibodies|
|Epitope||Regulatory Subunit 1 alpha Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This PRKACA antibody is conjugated to Alexa Fluor 488 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
|Supplier||Log in to see|
Product Details anti-PRKACA AntibodyTarget Details PRKACA Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human Protein Kinase A regulatory subunit I alpha|
Target Details PRKACAProduct Details anti-PRKACA Antibody Application Details Handling Images back to top
|Alternative Name||Prkar1 (PRKACA Antibody Abstract)|
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
Synonyms: Protein Kinase A regulatory subunit I alpha, cAMP dependent protein kinase regulatory subunit alpha 1, cAMP dependent protein kinase regulatory subunit RIalpha, cAMP dependent protein kinase type I alpha regulatory chain, cAMP dependent protein kinase type I alpha regulatory subunit, CAR, CNC 1, CNC, CNC1, DKFZp779L0468, MGC17251, PKA RIA, PKR 1, PKR1, PPNAD 1, PPNAD1, PRKAR 1, PRKAR1, PRKAR1A, Protein kinase A type 1a regulatory subunitv Protein kinase cAMP dependent regulatory type I alpha, Tissue specic extinguisher 1, TSE 1, TSE1, KAP0_HUMAN.
|Pathways||NF-kappaB Signaling, Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals|
Application DetailsProduct Details anti-PRKACA Antibody Target Details PRKACA Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PRKACA Antibody Target Details PRKACA Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|