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|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 11a, NFKB Activator (TNFRSF11A) Antibodies|
|Epitope||AA 1-213 Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This TNFRSF11A antibody is un-conjugated Alternatives|
|Supplier||Log in to see|
Product Details anti-TNFRSF11A AntibodyTarget Details TNFRSF11A Application Details Handling Images
|Characteristics||Produced in rabbits immunized with purified, recombinant Rat TNFRSF11A (rR TNFRSF11A, ABIN2009232 XP_573424.2, Met1-Pro213,. Total IgG was purified by Protein A affinity chromatography.|
|Purification||purified by Protein A affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Rat TNFRSF11A protein (ABIN2009232)|
Target Details TNFRSF11AProduct Details anti-TNFRSF11A Antibody Application Details Handling Images back to top
|Alternative Name||TNFRSF11A (TNFRSF11A Antibody Abstract)|
|Background||TNFRSF11A, also known as CD265, contains 4 TNFR-Cys repeats and belongs to the TNF- receptor superfamily. TNFRSF11A has an ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. TNFRSF11A can interact with various TRAF family proteins, through which this receptor induces the activation of NF- kappa B and MAPK8/JNK. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It is also an essential mediator for osteoclast and lymph node development. Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.|
Application DetailsProduct Details anti-TNFRSF11A Antibody Target Details TNFRSF11A Handling Images back to top
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat TNFRSF11A. The detection limit for Rat TNFRSF11A is approximately ≤ 0.039 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF11A Antibody Target Details TNFRSF11A Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|