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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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28.132376 | ABIN2482027 | ICC IF IP IHC WB | Atto 390 | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482031 | ICC IF IP IHC WB | Atto 633 | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482039 | ICC IF IP IHC WB | HRP | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482040 | ICC IF IP IHC WB | PE-Atto 594 | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482029 | ICC IF IP IHC WB | Atto 565 | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482030 | ICC IF IP IHC WB | Atto 594 | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482035 | ICC IF IP IHC WB | Alkaline Phosphatase (AP) | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482037 | ICC IF IP IHC WB | Biotin | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482034 | ICC IF IP IHC WB | Atto 700 | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482041 | ICC IF IP IHC WB | PerCP | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482036 | ICC IF IP IHC WB | APC | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482033 | ICC IF IP IHC WB | Atto 680 | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482038 | ICC IF IP IHC WB | FITC | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482043 | ICC IF IP IHC WB | Streptavidin | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482042 | ICC IF IP IHC WB | PE | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN2482028 | ICC IF IP IHC WB | Atto 488 | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | ||
28.132376 | ABIN1686656 | ICC IF IP IHC WB | Rabbit | AA 20-43 | Log in to see | Polyclonal | 2 | |||
20.632376 | ABIN5663550 | IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 1 | |||
20.5 | ABIN4900865 | CyTOF FACS Neut WB | Mouse | IgG1 | Log in to see | 16803 | 12 | |||
19.750505 | ABIN1980533 | ICC IHC WB | Rabbit | IgG | AA 248-428 | Log in to see | Polyclonal | 0 |
General |
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Antigen | Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) Antibodies |
Epitope | AA 20-43 Alternatives |
Reactivity | Cow (Bovine), Dog (Canine), Human, Monkey, Mouse (Murine), Rabbit, Rat (Rattus) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This TNFRSF1A antibody is conjugated to Atto 655 Alternatives |
Application |
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
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2 references available |
Supplier | Log in to see |
Product Details anti-TNFRSF1A AntibodyTarget Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A antibody (ABIN2482032) Images |
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Specificity | Detects ~55 kDa. |
Purification | Peptide Affinity Purified |
Immunogen | Peptide corresponding to AA 20-43 of the mouse TNF-R1 sequence, identical to rat and human over those residues |
Plasmids, Primers & others | |
Target Details TNFRSF1AProduct Details anti-TNFRSF1A Antibody Application Details Handling References for anti-TNFRSF1A antibody (ABIN2482032) Images back to top |
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Antigen | |
Alternative Name | TNFR1 (TNFRSF1A Antibody Abstract) |
Background | The Tumor Necrosis Factor Receptor (TNFR) also known as Cluster of differentiation (CD120) is a protein that belongs to the (TNF)/ (TNFR) superfamily. TNF interacts with two distinct receptors TNFR1 and TNFR2. These receptors share no homology on their cytoplasmic sequences(1,3).TNFR1 also known as p55/p60 is a high affinity receptor for TNF-α. The TNFR1 has an extracellular domain with variable numbers of cysteine-rich repeats. The functional properties of TNFR1 are targets in new therapies for osteoporosis, chronic inflammatory and autoimmune diseases (1, 2). The TNF-α/TNFR1 receptor complex is responsible for the recruitment and the subsequent activation of the caspase (aspartate-specific cysteine proteases) that regulate apoptosis. |
Gene ID | 9606 |
UniProt | P19438 |
Pathways | NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Hepatitis C |
Application DetailsProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Handling References for anti-TNFRSF1A antibody (ABIN2482032) Images back to top |
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Application Notes |
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Comment |
1 μg/ml of SPC-170 was sufficient for detection of TNFR1 in 20 μg of Hela lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. |
Restrictions | For Research Use only |
HandlingProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details References for anti-TNFRSF1A antibody (ABIN2482032) Images back to top |
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Format | Liquid |
Concentration | 1 mg/mL |
Buffer | PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | -20 °C |
References for anti-TNFRSF1A antibody (ABIN2482032)Product Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling Images back to top |
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Background publications |
Kontermann, Münkel, Neumeyer, Müller, Branschädel, Scheurich, Pfizenmaier: "A humanized tumor necrosis factor receptor 1 (TNFR1)-specific antagonistic antibody for selective inhibition of tumor necrosis factor (TNF) action." in: Journal of immunotherapy (Hagerstown, Md. : 1997), Vol. 31, Issue 3, pp. 225-34, 2008 Hehlgans, Pfeffer: "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games." in: Immunology, Vol. 115, Issue 1, pp. 1-20, 2005 |
ImagesProduct Details anti-TNFRSF1A Antibody Target Details TNFRSF1A Application Details Handling References for anti-TNFRSF1A antibody (ABIN2482032) back to top |
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Supplier Images |
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