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Human Monoclonal TNFSF11 Primary Antibody for ChIP, FACS - ABIN252476
Kikuchi, Matsuguchi, Tsuboi, Mitani, Tanaka, Matsuoka, Yamamoto, Hishikawa, Noguchi, Yoshikai: Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 20 Pubmed References
Human Polyclonal TNFSF11 Primary Antibody for IF (p), IHC (p) - ABIN672696
Yang, Li, Yang, Shen, Zou, Zhu, Zhang, Yang, Li: Efficacy and safety of echinacoside in a rat osteopenia model. in Evidence-based complementary and alternative medicine : eCAM 2013
Show all 15 Pubmed References
Human Polyclonal TNFSF11 Primary Antibody for IF (p), IHC (p) - ABIN668556
Zhang, Liu, Li, Bai: Mycobacterium tuberculosis 10-kDa co-chaperonin regulates the expression levels of receptor activator of nuclear factor-?B ligand and osteoprotegerin in human osteoblasts. in Experimental and therapeutic medicine 2015
Show all 11 Pubmed References
Human Monoclonal TNFSF11 Primary Antibody for ChIP, CyTOF - ABIN252546
Hsu, Lacey, Dunstan, Solovyev, Colombero, Timms, Tan, Elliott, Kelley, Sarosi, Wang, Xia, Elliott, Chiu, Black, Scully, Capparelli, Morony, Shimamoto, Bass, Boyle: Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. in Proceedings of the National Academy of Sciences of the United States of America 1999
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Human Monoclonal TNFSF11 Primary Antibody for ELISA - ABIN4249074
Pearse, Sordillo, Yaccoby, Wong, Liau, Colman, Michaeli, Epstein, Choi: Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. in Proceedings of the National Academy of Sciences of the United States of America 2001
Show all 9 Pubmed References
Human Monoclonal TNFSF11 Primary Antibody for CyTOF, FACS - ABIN4361916
Yoneda, Ishimaru, Arakaki, Kobayashi, Izawa, Moriyama, Hayashi: Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappa B ligand-mediated osteoclastogenesis. in Endocrinology 2004
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Mouse (Murine) Monoclonal TNFSF11 Primary Antibody for IHC (fro), FACS - ABIN2479510
Andersen, Jørgensen, Bardram, Hilsted: Screening for multiple endocrine neoplasia type 1 in patients with recognized pituitary adenoma. in Clinical endocrinology 1991
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Human Monoclonal TNFSF11 Primary Antibody for FACS, IHC (fro) - ABIN252684
Shetty, Pepin, Charest, Perron, Doyle, Voisine, Dagenais, Pibarot, Mathieu: Expression of bone-regulatory proteins in human valve allografts. in Heart (British Cardiac Society) 2006
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Human Polyclonal TNFSF11 Primary Antibody for IHC, IHC (p) - ABIN4361905
Lim, Liu, Hunter, Cheng, Mah, Helms: Downregulation of Wnt causes root resorption. in American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 2014
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Vascular smooth cells are a significant source of osteoprotegerin (show TNFRSF11B Antibodies) within the vasculature but that RANKL, once present, downregulates this production and appears capable of preventing the "protective" upregulation of OPG (show TNFRSF11B Antibodies) seen with VSMCs exposed to physiological levels of cyclic strain.
receptor activator for nuclear factor-kappa B ligand (RANKL), secreted by human embryonic trophoblasts and maternal decidual stromal cells, polarizes decidual macrophages toward a M2 phenotype.
There were no significant associations involving the RANKL gene. Thus, it is suggested that alterations in the OPG (show TNFRSF11B Antibodies) and RANK genes are primarily responsible for altering the function and expression of the RANKL ligand, resulting in a predisposition to chronic arthralgia and comorbid temporomandibular OA.
Vitamin D, tumor necrosis factor (TNF)-alpha (show TNF Antibodies), receptor activator of nuclear factor-KB ligand (RANKL), and OPG (show TNFRSF11B Antibodies) levels were determined in GCF (show GUCY2F Antibodies) and serum. Baseline clinical parameters were similar in all periodontitis groups (P > 0.05) but were higher than that in controls
down-regulated miR (show MLXIP Antibodies)-143-5p promotes the differentiation of DPSCs into odontoblasts by enhancing Runx2 (show RUNX2 Antibodies) expression via the OPG/RANKL signaling pathway.
OPG (show TNFRSF11B Antibodies) and OPG (show TNFRSF11B Antibodies)/TRAIL ratio expression were significantly increased in rheumatoid arthritis patients compared to controls (fold change = 1.79, p = 0.013 and 2.07, p = 0.030, respectively), RANKL/OPG ratio was significantly decreased (fold change = 0.50, p = 0.020). No significant differences were found between patients and controls in RANKL and TRAIL expression.
Results show that pro-inflammatory cytokines upregulated SOX5 (show SOX5 Antibodies) and RANKL expression in both synovial fibroblasts of patients with primary rheumatoid arthritis and cell line. IL-6 (show IL6 Antibodies) facilitates the binding of SOX5 (show SOX5 Antibodies) to RANKL promoter.
Higher concentrations of serum sRANKL were positively associated with risk of estrogen receptor (show ESR1 Antibodies) positive breast cancer.
RANKL is overexpressed in invariant NKT (show SLC22A6 Antibodies) cells in bone marrow of patients with multiple myeloma.
triple-negative breast cancer (TNBC) patients that expressed both RANK and RANKL proteins had significantly worse RFS and OS than patients with RANK-positive, RANKL-negative tumors. RANKL was an independent, poor prognostic factor for RFS and OS in multivariate analysis in samples that expressed both RANK and RANKL.
RANKL and Src (show SRC Antibodies) has an unrecognized role in osteocyte survival.
compressive force induced the differentiation of RAW264.7 from increase in RANK and decrease in LGR4 (show LGR4 Antibodies) expression.
miR (show MLXIP Antibodies)-145 expression was inhibited in RANKL-induced osteoclastogenesis
LPS (show TLR4 Antibodies) increased mRNA and protein expressions of IL-6 (show IL6 Antibodies) and RANKL on day 14
hBD-1 potentiates the induction of in vitro osteoclastogenesis by RANKL via enhanced phosphorylation of the p44/42 MAPKs
findings indicate that STAT5 (show STAT5A Antibodies) contributes to the remarkable IL-3 (show IL-3 Antibodies)-mediated inhibition of RANKL-induced osteoclastogenesis by activating Id genes and their associated pathways.
RANKL/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer.
Rankl(-/-) bone marrow-mesenchymal stromal cell displayed reduced clonogenicity and osteogenic capacity.
In this study, the authors identified by gene expression profiling that microgravity induces high levels of TRAIL expression in murine preosteoclast cells in the absence of RANKL stimulation compared to ground based cultures.
These results suggest that LOX (show LOX Antibodies) has the ability to induce RANKL expression on stromal cells; however, it fails to substitute for RANKL in osteoclastogenesis.
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
TNF-related activation-induced cytokine
, osteoclast differentiation factor
, osteoprotegerin ligand
, receptor activator of nuclear factor kappa B ligand
, receptor activator of nuclear factor kappa-B ligand
, tumor necrosis factor ligand superfamily member 11
, tumor necrosis factor (ligand) superfamily, member 11
, Receptor activator of nuclear factor kappa-B ligand
, tumor necrosis factor receptor superfamily member 11B
, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
, OPG ligand
, receptor activator of NF-kappaB ligand
, tumor necrosis factor-related activation-induced cytokine
, TNF superfamily member 11 L homeolog
, tumor necrosis factor superfamily member 11 L homeolog