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ADAM7 is required for normal fertility and is important for the maintenance of epididymal integrity and for sperm morphology
Suggest that Adam7 functions in fertilization through the formation of a complex with heat shock protein 5 (show HSPA5 Proteins), calnexin (show CANX Proteins) and Itm2b (show ITM2B Proteins) during capacitation in sperm.
This study provides new information regarding the unique mode of secretion and interaction of ADAM7 during the epididymis-to-sperm transfer process.
mutated ADAM27 (show ADAM18 Proteins) and ADAM7 genes could play a role in melanoma progression.
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma.
ADAM metallopeptidase domain 7
, a disintegrin and metalloproteinase domain 7
, ADAM 7
, a disintegrin and metalloprotease domain (ADAM) 7
, a disintegrin and metalloprotease domain 7
, disintegrin and metalloproteinase domain-containing protein 7
, epididymal apical protein I
, sperm maturation-related glycoprotein GP-83
, a disintegrin and metallopeptidase domain 7