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frameshift mutations in DTX1 and NLRC5, two genes involved in immune regulation, were identified in a family with familial pityriasis rubra pilaris.
DTX1 is an E3 ligase for c-FLIP in gastric cancer cells.
Deltex-1 mutations predict poor survival in diffuse large B-cell lymphoma
PI5P4Kgamma positively regulates the DTX1-mediated Notch pathway by promoting receptor recycling
Data indicate that decreased expression of deltex E3 ubiquitin ligase 1 (DTX1) in head and neck squamous cell carcinoma (HNSCC) tumors maybe associated with NOTCH pathway activation and increased migration potential.
Two SNPs (rs2384077 and rs10744794) in an intron of DTX1 and the linkage disequilibrium (LD) block are significantly associated with the immune response to HBV vaccination.
this study reports the identification of two new hGIP-interacting partners, DTX1 and STAU1.
characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch pathway and a new Kelch-like protein, KLHL6
It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination.
exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 protein
DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
NB-3/Notch1 pathway promotes neural progenitor cell differentiation into
Deltex selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1.
Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function.
Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development[Deltex1]
Data show that Deltex1 ablation enabled Id1-expressing progenitors to differentiate to the DN3 (CD44(-) CD25(+)) stage, which was accompanied by enhanced Notch1 expression in T-cell progenitors.
deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation
Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function\; however, it may play a role in basic helix-loop-helix transcription factor activity.
E3 ubiquitin-protein ligase DTX1
, protein deltex-1
, deltex homolog 1 (Drosophila)
, fractionated x-irradiation induced transcript 1
, deltex 1
, deltex 1 S homeolog
, deltex 1, E3 ubiquitin ligase S homeolog