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Human DLL4 Protein expressed in Human Cells - ABIN2002236
Dorsch, Zheng, Yowe, Rao, Wang, Shen, Murphy, Xiong, Shi, Gutierrez-Ramos, Fraser, Villeval: Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. in Blood 2002
Show all 6 Pubmed References
Data show that Delta-like 4 (DLL4) and Jagged1 (JAG1) displayed equal potency in stimulating Notch target genes in HMEC-1 dermal microvascular endothelial cells but had opposing effects on sprouting angiogenesis in vitro.
epigenetic silencing and TP53 (show TP53 Proteins) mutation have an effect on the expression of DLL4 in human cancer stem disorder
the Notch (show NOTCH1 Proteins) signaling and atherosclerosis relevant markers in lesions from femoral arteries of symptomatic peripheral artery disease patients, were characterized.
Data suggest that Numb (show NUMB Proteins) acts as a Notch (show NOTCH1 Proteins) antagonist by controlling intracellular destination and stability of the Notch ligand (show JAG2 Proteins) Delta-like (show DLK1 Proteins) 4 (DLL4) through a post-endocytic sorting process; Numb (show NUMB Proteins) negatively controls DLL4 plasma membrane recycling through well-documented recycling regulator protein AP1 (show FOSB Proteins).
Results show that DLL4 is involved in SYNJ2BP (show SYNJ2BP Proteins)-induced hepatocellular carcinoma (HCC (show FAM126A Proteins)) development though activating its pathway.
Positive Jagged1 (show JAG1 Proteins) and DLL4 expression is closely correlated with severe clinicopathological characteristics and poor prognosis in patients with gallbladder cancers.
We show that GIT1, which also contains an ANK domain, inhibits the Notch1 (show NOTCH1 Proteins)-Dll4 signaling pathway by competing with Notch1 (show NOTCH1 Proteins) ANK domain for binding to RBP-J (show RBPJ Proteins) in stalk cells
Results provide evidence that DLL4 is associated with gastric cancer stem/progenitor cells (GCSPCs), and its expression impacts CSPC (show GZMH Proteins) stemness characteristics associated with the Notch-1 (show NOTCH1 Proteins) pathway including self-renewal, differentiation, proliferation, and tumor formation.
The authors present novel structures of human ligands Jagged2 (show JAG2 Proteins) and Delta-like4 and human Notch2 (show NOTCH2 Proteins), together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch (show NOTCH1 Proteins) binding is likely to be critical in establishing the optimal context for Notch (show NOTCH1 Proteins) signalling.
Overexpression of DLL4 could significantly attenuate the cytotoxic effects of docetaxel in MCF-7 cells by increasing Bcl-2 (show BCL2 Proteins) expression, while decreasing Bax (show BAX Proteins) expression, apoptosis rate and DNA damage
Data suggest that endothelial specific Delta-like (show DLK1 Proteins) 4 (Dll4) overexpression appears as a promising anti-angiogenic modality that might improve cancer control.
Dll4 seems to promote Apc (show APC Proteins) (Min/+) tumorigenesis.
Dll4-Notch1 (show NOTCH1 Proteins) signalling couples sprouting angiogenesis and artery formation.
Results suggest that Dll4 activation during differentiation sustained Treg cell phenotype and function to control respiratory syncytial virus infection.
DLL4 expression is not associated with the Pathogenesis of Non-Alcoholic Steatohepatitis.
The results demonstrate that the Vegf (show VEGFA Proteins)-Dll4/Notch (show NOTCH1 Proteins) feedback system normally operates to generate heterogeneity between endothelial cells driving blood vessel branching, whilst synchronization drives vessel expansion.
Dll4 modulates liver inflammatory response by down-regulating chemokine (show CCL1 Proteins) expression
Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 (show NOTCH1 Proteins) Signaling
miRNA-30e targeted the 3'-UTR of Dll4 and downregulated Dll4 expression
Dll4/Notch (show NOTCH1 Proteins) signaling and HIF-1alpha (show HIF1A Proteins) are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.
Tmem230a may have a modulatory role in vessel-network formation and growth, regulating endothelial cell number by Dll4/Notch (show NOTCH1 Proteins) pathway.
Thsd7a (show THSD7A Proteins) could regulate ISV angiogenesis via Notch (show NOTCH1 Proteins)-dll4 signaling. Thus, Thsd7a (show THSD7A Proteins) is a potent angioneurin involved in the development of both neural and vascular systems.
show that blood flow suppresses vascular Notch (show NOTCH1 Proteins) signalling via down-regulation of dll4
Microinjection of miR (show MYLIP Proteins)-30 mimics into zebrafish embryos resulted in suppression of dll4 and subsequent excessive sprouting of intersegmental vessels and reduction in dorsal aorta diameter.
Notch (show NOTCH1 Proteins) signalling pathway mutants Ectopic filopodia were also observed on the inter-somitic vessels of Notch (show NOTCH1 Proteins) signalling pathway mutants. Ectopic filopodia are not due to loss of dll4.
These studies imply critical roles for Dll4/Notch (show NOTCH1 Proteins) signaling in the formation and wiring of the lymphatic network.
Dll4-Notch (show NOTCH1 Proteins) signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf (show VEGFA Proteins).
Vegfc (show VEGFC Proteins)/Flt4 (show FLT4 Proteins) signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.
delta-like protein 4
, delta 4
, delta ligand 4
, delta-like 4 homolog
, delta-like 4 protein
, drosophila Delta homolog 4
, notch ligand DLL4
, notch ligand delta-2