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anti-Rat (Rattus) FBXW7 Antibodies:
anti-Human FBXW7 Antibodies:
anti-Mouse (Murine) FBXW7 Antibodies:
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Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN527479
Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. in Cell reports 2012
Show all 5 Pubmed References
Human Polyclonal FBXW7 Primary Antibody for ICC, IF - ABIN4892424
Lu, Pfeffer: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. in The Journal of cell biology 2013
Show all 4 Pubmed References
Human Polyclonal FBXW7 Primary Antibody for IP - ABIN257813
Bengoechea-Alonso, Ericsson: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 2 Pubmed References
Human Polyclonal FBXW7 Primary Antibody for IF (p), IHC (p) - ABIN1386103
Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. in Biochemical and biophysical research communications 2015
Human Polyclonal FBXW7 Primary Antibody for IF, WB - ABIN527477
Maskey, Marlin, Kim, Kim, Ong, Li, Tsiokas: Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. in The EMBO journal 2015
Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2780093
Huang, Ma, Li, Yu, Zhang, Wei, Jin, Xu, Gao, Huang: NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. in Oncotarget 2014
Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2782955
Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. in Nature genetics 2014
Human Monoclonal FBXW7 Primary Antibody for IHC, WB - ABIN2674168
Wang, Zhang, Zhou, Sun, Zheng, Lu, Gao, Yang, Zhang, Tao, Dou: Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway. in International journal of oncology 2015
FBXW7 was a downstream target of miR (show MLXIP Antibodies)-367 and CASC2 prohibited epithelial-to-mesenchymal transition progression and subsequently exerted its anti-metastatic effects via CASC2/miR (show MLXIP Antibodies)-367/FBXW7 axis in hepatocellular carcinoma cells.
FBW7 cooperated with gamma-catenin (show JUP Antibodies) to inhibit G2/M cell cycle transition and cell proliferation.
We also propose a model for the stabilization mechanism in which binding to Aurora-A (show AURKA Antibodies) alters how N-Myc (show MYCN Antibodies) interacts with SCF (show KITLG Antibodies)(FbxW7) to disfavor the generation of Lys48-linked polyubiquitin (show UBB Antibodies) chains
We find that both primary and recurrent Squamous cell carcinoma of the anal canal (ASCC) tumors harbor mutations in genes, such as PIK3CA (show PIK3CA Antibodies) and FBXW7, that are also mutated in other HPV-associated cancers. Overall mutational burden was not significantly different in pre- versus post-CRT (show SLC6A8 Antibodies) tumors, and several examples of shared clonal driver mutations were identified
We have identified low FBXW7 expression as a potential powerful marker of poor prognosis in patients with gastric adenocarcinoma. Furthermore, in view of the different chemotherapeutics outcomes found in this large database study, FBXW7 may serve as an important predictor in chemotherapeutic responses.
Fbxw7 haploinsufficiency increased the risk of gastric carcinogenesis induced by MNU, which is associated with the accumulation of DNA damage as well as c-Myc (show MYC Antibodies) oncoprotein.
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
FAM83D (show FAM83D Antibodies) knockdown up-regulated the protein expression level of F-box and WD repeat domain-containing 7 (FBXW7), but diminished the Notch1 (show NOTCH1 Antibodies) protein expression level.
Thus, our study uncovers a novel regulatory mechanism underlying which KLF10 (show KLF10 Antibodies) stability and its biological function are mediated by FBW7.
Results found it showed reduced expression in diffuse large B-cell lymphoma (DLBCL), which was associated with a poor outcome. Fbw7 expression promotes apoptosis in DLBCL cell lines. Furthermore, the study demonstrated that Fbw7 targets Stat3 (show STAT3 Antibodies) and especially activated Stat3 (show STAT3 Antibodies) for ubiquitylation to regulate its stability.
found that Fbw7 loss caused activation of NF-kappaB (show NFKB1 Antibodies) signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB (show NFKB1 Antibodies) pathway.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (show HLCS Antibodies)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (show NOTCH2 Antibodies) pathway as observed in patients with HCS (show HLCS Antibodies).
The findings reveal a PLK1 (show PLK1 Antibodies)-Fbw7-Myc (show MYC Antibodies) signaling circuit that underlies tumorigenesis and validate PLK1 (show PLK1 Antibodies) inhibitors, alone or with Bcl2 (show BCL2 Antibodies) antagonists, as potential effective therapeutics for MYC (show MYC Antibodies)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Antibodies)-dependent mechanism.
Study identifies a REV-ERBalpha (show NR1D1 Antibodies) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Antibodies)) phosphorylation of REV-ERBalpha (show NR1D1 Antibodies) is recognized by the F-box protein (show FBXO30 Antibodies), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Antibodies) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Antibodies)-FBXW7-mediated REV-ERBalpha (show NR1D1 Antibodies) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Antibodies) pathway in radiation-induced mouse thymic lymphomas.
Prion (show PRNP Antibodies) infection induced the expression of FBXW7 in brain.
FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Antibodies) in tumor cells.
data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 for ubiquitin-mediated degradation in a GSK3beta-dependent manner
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30