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Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN527479
Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. in Cell reports 2012
Show all 5 Pubmed References
Human Polyclonal FBXW7 Primary Antibody for ICC, IF - ABIN4892424
Lu, Pfeffer: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. in The Journal of cell biology 2013
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Human Polyclonal FBXW7 Primary Antibody for IP - ABIN257813
Bengoechea-Alonso, Ericsson: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 2 Pubmed References
Human Polyclonal FBXW7 Primary Antibody for IF (p), IHC (p) - ABIN1386103
Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. in Biochemical and biophysical research communications 2015
Human Polyclonal FBXW7 Primary Antibody for IF, WB - ABIN527477
Maskey, Marlin, Kim, Kim, Ong, Li, Tsiokas: Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. in The EMBO journal 2015
Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2780093
Huang, Ma, Li, Yu, Zhang, Wei, Jin, Xu, Gao, Huang: NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. in Oncotarget 2014
Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2782955
Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. in Nature genetics 2014
Human Monoclonal FBXW7 Primary Antibody for IHC, WB - ABIN2720979
Wang, Zhang, Zhou, Sun, Zheng, Lu, Gao, Yang, Zhang, Tao, Dou: Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway. in International journal of oncology 2015
we identified F-box and WD repeat domain-containing 7 (FBXW7) protein as a direct functional target of miR (show MLXIP Antibodies)-25 in esophageal squamous cell carcinoma (ESCC). In conclusion, the present study supports the potential of miR (show MLXIP Antibodies)-25 as a prognostic predictor with its high expression in cancer tissues and its association with tumor progression by targeting FBXW7 in ESCC
FBXW7 was significantly downregulated in renal cell carcinoma (show MOK Antibodies) cell lines. Upregulation of FBXW7 in 786-O and ACHN (show LARP6 Antibodies) cell lines significantly inhibited cell migration, invasion and EMT (show ITK Antibodies).
FBXW7 missense mutation is associated with metastatic colorectal adenocarcinoma.
miR (show MLXIP Antibodies)-92b-3p inhibition prevented colorectal cancer proliferation, invasion, and migration by upregulating FBXW7, which might suggest the potential role of miR (show MLXIP Antibodies)-92b-3p in colorectal carcinogenesis and metastasis.
FBXW7 is markedly downregulated in the liver of obese subjects. A functional low-frequency human FBXW7 coding variant ( (show AHSG Antibodies)p.Ala204Thr) is associated with elevated blood glucose and T2DM risk in a Chinese population. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
Our findings suggest FBW7 mutational status and Mcl-1 (show MCL1 Antibodies) stability as key determinants of response to Hsp90 (show HSP90 Antibodies) inhibitors, which provides a rationale for using FBW7 genotype for potential patient stratification, and for drug combinations with Hsp90 (show HSP90 Antibodies) inhibitors that can effectively overcome Mcl-1 (show MCL1 Antibodies)-mediated resistance.
a cancer stem cell-specific FBXW7-regulatory mechanism is strongly associated with resistance to chemotherapeutic agents.
FBW7 promoted gemcitabine sensitivity via upregulation of equilibrative nucleoside transporter 1 (ENT1 (show SLC29A1 Antibodies)) at the protein level rather than the transcriptional level.
FBW7 overexpression downregulated Aurora B (show AURKB Antibodies), Mcl1 (show MCL1 Antibodies) and Notch1 (show NOTCH1 Antibodies) levels.
FBXW7 was a downstream target of miR (show MLXIP Antibodies)-367 and CASC2 prohibited epithelial-to-mesenchymal transition progression and subsequently exerted its anti-metastatic effects via CASC2/miR (show MLXIP Antibodies)-367/FBXW7 axis in hepatocellular carcinoma cells.
FBXW7 is markedly downregulated in the liver of obese mice. Mechanistically, FBXW7 directly binds to hepatokine fetuin-A (show AHSG Antibodies) to induce its ubiquitination and subsequent proteasomal degradation, comprising an important mechanism maintaining glucose homeostasis.
the regulatory crosstalk between KLF5 (show KLF5 Antibodies), miR (show MLXIP Antibodies)-29a, and Fbw7/CDC4 cooperatively promotes atherosclerotic development
found that Fbw7 loss caused activation of NF-kappaB (show NFKB1 Antibodies) signaling. Thus, FBW7 plays a protective role in acute intestinal inflammation by modulating the inflammatory response of NF-kappaB (show NFKB1 Antibodies) pathway.
EglN2 might act as an FBW7 ubiquitin ligase substrate contributing to the progression of triple negative breast cancer.
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (show HLCS Antibodies)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (show NOTCH2 Antibodies) pathway as observed in patients with HCS (show HLCS Antibodies).
The findings reveal a PLK1 (show PLK1 Antibodies)-Fbw7-Myc (show MYC Antibodies) signaling circuit that underlies tumorigenesis and validate PLK1 (show PLK1 Antibodies) inhibitors, alone or with Bcl2 (show BCL2 Antibodies) antagonists, as potential effective therapeutics for MYC (show MYC Antibodies)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Antibodies)-dependent mechanism.
Study identifies a REV-ERBalpha (show NR1D1 Antibodies) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Antibodies)) phosphorylation of REV-ERBalpha (show NR1D1 Antibodies) is recognized by the F-box protein (show FBXO30 Antibodies), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Antibodies) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Antibodies)-FBXW7-mediated REV-ERBalpha (show NR1D1 Antibodies) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Antibodies) pathway in radiation-induced mouse thymic lymphomas.
Prion (show PRNP Antibodies) infection induced the expression of FBXW7 in brain.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30