Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Rat (Rattus) FBXW7 Antibodies:
anti-Human FBXW7 Antibodies:
anti-Mouse (Murine) FBXW7 Antibodies:
Go to our pre-filtered search.
Human Monoclonal FBXW7 Primary Antibody for IHC (p), ELISA - ABIN527479
Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: Structural basis for a reciprocal regulation between SCF and CSN. in Cell reports 2012
Show all 5 Pubmed References
Human Polyclonal FBXW7 Primary Antibody for ICC, IF - ABIN4892424
Lu, Pfeffer: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression. in The Journal of cell biology 2013
Show all 4 Pubmed References
Human Polyclonal FBXW7 Primary Antibody for IP - ABIN257813
Bengoechea-Alonso, Ericsson: The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 2 Pubmed References
Human Polyclonal FBXW7 Primary Antibody for IF, WB - ABIN527477
Maskey, Marlin, Kim, Kim, Ong, Li, Tsiokas: Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. in The EMBO journal 2015
Human Monoclonal FBXW7 Primary Antibody for IHC, WB - ABIN2674168
Wang, Zhang, Zhou, Sun, Zheng, Lu, Gao, Yang, Zhang, Tao, Dou: Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway. in International journal of oncology 2015
Human Polyclonal FBXW7 Primary Antibody for IF (p), IHC (p) - ABIN1386103
Wang, Yang, Liu, Huang, Wang, Chen, Chen: RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway. in Biochemical and biophysical research communications 2015
Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2780093
Huang, Ma, Li, Yu, Zhang, Wei, Jin, Xu, Gao, Huang: NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression. in Oncotarget 2014
Cow (Bovine) Polyclonal FBXW7 Primary Antibody for IHC, WB - ABIN2782955
Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins. in Nature genetics 2014
Thus, our study uncovers a novel regulatory mechanism underlying which KLF10 (show KLF10 Antibodies) stability and its biological function are mediated by FBW7.
Results found it showed reduced expression in diffuse large B-cell lymphoma (DLBCL), which was associated with a poor outcome. Fbw7 expression promotes apoptosis in DLBCL cell lines. Furthermore, the study demonstrated that Fbw7 targets Stat3 (show STAT3 Antibodies) and especially activated Stat3 (show STAT3 Antibodies) for ubiquitylation to regulate its stability.
Data suggest that FBXW7, MCL1 (show MCL1 Antibodies) and PLK1 (show PLK1 Antibodies) may be relevant predictive markers of tumor progression and response to paclitaxel treatment.
FBW7 serves as a negative regulator of glucose metabolism through regulation of the c-Myc (show MYC Antibodies)/TXNIP (show TXNIP Antibodies) axis in pancreatic cancer.
increased expression of activated NOTCH1 (show NOTCH1 Antibodies) was found in NOTCH1 (show NOTCH1 Antibodies)/FBXW7 hotspot exon-mutated cases. Study suggests that NOTCH1 (show NOTCH1 Antibodies)/FBXW7 hotspot-mutated T-ALL cases had better response to ALL BFM-95 protocol.
Study identify SCF (show KITLG Antibodies)-FBW7 as a ubiquitin E3 ligase that regulates the cellular FAAP20 levels and Fanconi anemia (show PALB2 Antibodies) (FA) pathway. Deregulation of the GSK3beta (show GSK3b Antibodies)- and FBW7-dependent FAAP20 degradation leads to a defect in the FA pathway, establishing a direct link between FBW7 and DNA repair.
HRAS (show HRAS Antibodies) mutations were more common in epithelial-myoepithelial carcinomas (EMCAs) with intact PLAG1 (show PLAG1 Antibodies) and HMGA2. Most EMCAs arose ex pleomorphic adenoma (PA)and the genetic profile of EMCA varies with the absence or presence of preexisting PA and its cytogenetic signature. Progression to higher grade EMCA with intact PLAG1 (show PLAG1 Antibodies) and HMGA2 correlates with the presence of TP53 (show TP53 Antibodies), FBXW7 mutations, or SMARCB1 (show SMARCB1 Antibodies) deletion.
Data indicate the SCF (show KITLG Antibodies)(Fbxw7)-independent regulatory mechanism centred on the highly conserved lysine-52 (K52) within MYC (show MYC Antibodies) Box I.
Results identified FBXW7 as a functional target of miR (show MLXIP Antibodies)-155-3p and demonstrated an involvement of FBXW7 in the effects of increased miR (show MLXIP Antibodies)-155-3p on promoting clone formation and proliferation of hepatocellular carcinoma.
FBXW7alpha inhibits breast cancer cells survival by promoting GATA3 (show GATA3 Antibodies) degradation/destabilizing GATA3 (show GATA3 Antibodies).
These findings highlight the molecular basis of Hajdu-Cheney syndrome (HCS (show HLCS Antibodies)) pathogenesis and provide clinical insights into potential targeted therapeutic strategies for skeletal disorders associated with the aberrant FBW7/NOTCH2 (show NOTCH2 Antibodies) pathway as observed in patients with HCS (show HLCS Antibodies).
The findings reveal a PLK1 (show PLK1 Antibodies)-Fbw7-Myc (show MYC Antibodies) signaling circuit that underlies tumorigenesis and validate PLK1 (show PLK1 Antibodies) inhibitors, alone or with Bcl2 (show BCL2 Antibodies) antagonists, as potential effective therapeutics for MYC (show MYC Antibodies)-overexpressing cancers.
Fbxw7 suppresses KrasG12D-induced pancreatic tumorigenesis via a Yap (show YAP1 Antibodies)-dependent mechanism.
Study identifies a REV-ERBalpha (show NR1D1 Antibodies) post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Antibodies)) phosphorylation of REV-ERBalpha (show NR1D1 Antibodies) is recognized by the F-box protein (show FBXO30 Antibodies), FBXW7alpha, to direct REV-ERBalpha (show NR1D1 Antibodies) degradation via the proteasome. Disruption of this CDK1 (show CDK1 Antibodies)-FBXW7-mediated REV-ERBalpha (show NR1D1 Antibodies) degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
Gene expression profiling reveals transcriptional regulation by Fbxw7/mTOR (show FRAP1 Antibodies) pathway in radiation-induced mouse thymic lymphomas.
Prion (show PRNP Antibodies) infection induced the expression of FBXW7 in brain.
FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 (show XRCC4 Antibodies) in tumor cells.
data demonstrate that Fbw7alpha negatively regulates osteogenesis by targeting Runx2 (show RUNX2 Antibodies) for ubiquitin-mediated degradation in a GSK3beta (show GSK3b Antibodies)-dependent manner
In mice, an unusually direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28 (show USP28 Antibodies), modulate intestinal homeostasis and cancer.
These data show that cell cycle-dependent mechanisms can control ciliary length through a CDK5-FBW7-NDE1 pathway.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.
F-box and WD-40 domain protein 7
, F-box/WD repeat-containing protein 7
, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
, F-box protein FBW7
, F-box protein FBX30
, F-box protein SEL-10
, homolog of C elegans sel-10
, F-box and WD-40 domain protein 7, archipelago homolog
, F-box and WD-40 domain-containing protein 7
, F-box protein Fbxw6
, F-box-WD40 repeat protein 6
, f-box only protein 30