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NEURL rs12415501 and CAND2 (show CAND2 Proteins) rs4642101 are significantly associated with postoperative atrial fibrillation susceptibility after coronary artery bypass grafting among Chinese population
Fe65 (show APBB1 Proteins) negatively regulates Jagged1 (show JAG1 Proteins) signaling by decreasing Jagged1 (show JAG1 Proteins) protein stability through the E3 ligase Neuralized-like 1.
NEURL1 expression was downregulated in medulloblastoma compared to normal cerebellar tissue with lowest expression levels in hedgehog (show SHH Proteins)-activated tumors; conclude NEURL1 is candidate tumor suppressor in MB at least in part through effects on Notch (show NOTCH1 Proteins) pathway
Neu1 inhibits lipolysis induced by beta-adrenergic stimulation in adipocytes via interactions with Plin1 (show PLIN1 Proteins) on lipid drops.
Neu1 is the only lysosomal multienzyme complex gene underexpressed in mucopolysaccharidosis type I mice.
Neu1 desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.
Data indicate a role for neuraminidase 1 (Neu1 (show NEU1 Proteins)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (show TLR4 Proteins)) interaction and endotoxemia.
elastin (show ELN Proteins)-derived peptides as an enhancer of atherogenesis and defines the Neuraminidase 1 (show NEU1 Proteins)/PI3Kgamma (show PIK3CG Proteins) signalling pathway as a key mediator
significant increases in Col1a1 (show COL1A1 Proteins), serine/threonine-protein kinase 1, Ctnnb1 (show CTNNB1 Proteins), CSRNP1 (show CSRNP1 Proteins), Ddit4 (show DDIT4 Proteins), Cyp2e1 (show CYP2E1 Proteins), and Krit1 (show KRIT1 Proteins) expressions and great decreases inreceptor D2, Neu1, and Dhcr7 (show DHCR7 Proteins) expressions following long-term exposure to TiO2 NPs (show NPS Proteins)
NEU1 deficiency has a role in determining amyloid precursor protein (show APP Proteins) levels and amyloid-beta secretion via deregulated lysosomal exocytosis
Neu1 sialidase and matrix metalloproteinase-9 (show MMP9 Proteins) cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 (show TLR7 Proteins) and -9 activation, cellular signaling and pro-inflammatory responses.
The activity of NEU1 was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice.
Catalyzes the removal of sialic acid (N-acetylneuramic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage (By similarity).
, neuralized-like protein 1A
, neuralized homolog (Drosophila)
, neuralized-like protein 1A-like
, RING finger protein 67
, h-neuralized 1
, m-neuralized 1
, neuralized-like homolog
, neuralized-like protein 1
, G9 sialidase
, HLA-B-associated transcript 7
, N-acetyl-alpha-neuraminidase 1
, lysosomal sialidase
, sialidase 1