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Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
This study indicates that NOTCH1 acts as an oncogene (show RAB1A Proteins) and that the NOTCH1 mutation (p.A465T) in the ligand-binding region causes the loss of tumorigenicity by downregulating the NOTCH1 pathway
a non-canonical Notch complex drives the assembly of adherens junctions and is crucial for the establishment and maintenance of the endothelial barrier, which is essential to vascular health
NF-E2 (show NFE2 Proteins) silencing in hematopoietic stem and progenitor cells (HSPCs) did not affect their myeloid and B cell differentiation in vivo, it almost abrogated T cell production in primary hosts, as confirmed by in vitro studies. This effect is at least partly due to Notch1 downregulation in NF-E2 (show NFE2 Proteins)-silenced HSPCs.
The study might indicate that rs312599 in Notch1 may be a novel biomarker for small cell lung cancer risk in Chinese non-smoking females.
Results report a prevailing hyperactivation of the Notch1 receptor in human in clear cell renal cell carcinoma (show MOK Proteins).
Obesity was associated with higher expression of NILCO molecules (Notch-IL1 (show IL1A Proteins)-leptin (show LEP Proteins)) in type II endometrial cancer.
Our findings demonstrate Hsp90 (show HSP90 Proteins) blockade leads to ICN1 destabilization, providing an alternative strategy to antagonize oncogenic Notch1 signaling with Hsp90 (show HSP90 Proteins)-selective inhibitors
Notch is ligand activated and undergoes DTX4 (show DTX4 Proteins)-mediated ubiquitylation and bilateral endocytosis before ADAM10 (show ADAM10 Proteins) processing
we determined that Notch1 regulates the JNK (show MAPK8 Proteins) signaling pathway and increases apoptosis in hepatocellular carcinoma.
We did not detect any mutation in the NOTCH1 gene (exons 5, 6, 7, 8, and 9) in all the [0/44] analyzed oral cancer samples.
Smooth muscle PLCgamma1 (show PLCG1 Proteins)-Akt (show AKT1 Proteins)-mediated Notch1 signaling is crucial for intima formation in vascular injury.
inhibition of PTEN by Notch1/Hes1 (show HES1 Proteins) in response to high glucose concentration inhibits autophagy, which is associated with the progression of fibrosis in diabetic nephropathy
Results indicate that Notch signaling induces cell cycle arrest and thereby initiates chondrocyte cell enlargement via bone morphogenetic protein 2 (BMP2 (show BMP2 Proteins)) signaling.
Notch signaling plays a critical role in dendrite development of immature neurons in the postnatal brain.
Here, we found the dynamic changes of Notch1 were coincided with autophagy: they both increased during kidney development and podocyte differentiation...to better understand the relationship between Notch signalling and autophagy in podocyte differentiation, rapamycin was added to enhance autophagy levels in DAPT-treated cells, and as a result, nephrin (show NPHS1 Proteins) was recovered and DAPT-induced injury was ameliorated
this paper shows the critical role of the Notch1-Hes1 (show HES1 Proteins) signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation
Kaiso (show ZBTB33 Proteins) promotes Jagged-1 (show JAG1 Proteins) expression, which may have implications in Notch-mediated colon cancer progression
Data identified WISP-1 (show WISP1 Proteins) as a key downstream secretory mediator of Notch1 signaling to execute the influential role of MSC (show MSC Proteins)-DF on melanoma metastasis.
Taken together, these findings indicate that GAS5 may promote the progression of ischemic stroke through acting as a ceRNA for miR (show MLXIP Proteins)-137 to mediate the Notch1 signaling pathway, which contributes to an extensive understanding of ischemic stroke and may provide novel therapeutic options for this disease.
Data show that Wnt (show WNT2 Proteins) beta-Catenin (show CTNNB1 Proteins) signaling pathway activation followed by Notch inhibition strongly promotes the mitotic regeneration of new hair cell (HC) in both normal and neomycin-damaged cochleae.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Proteins) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Proteins) gene or the constitutively active form of Notch (IC).
ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Proteins) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Proteins)) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Proteins)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (show SMAD2 Proteins) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Proteins) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog