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Mouse (Murine) Notch1 Protein expressed in CHO Cells - ABIN1344230
Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. in Journal of immunology (Baltimore, Md. : 1950) 2009
we concluded that downregulation of Notch-1 could be a promising approach for inhibition of invasion in prostate cancer cells, which could be useful for the treatment of metastatic prostate cancer
Authors show that compared to normal prostate tissue, Notch1 expression is reduced in a substantial fraction of human PCas while it is unaffected or even increased in others; acute Notch activation both inhibits and induces process networks associated with prostatic neoplasms; down-modulation of Notch1 expression and activity in immortalized normal prostate epithelial cells increases their proliferation.
Kaiso (show ZBTB33 Proteins) promotes Jagged-1 (show JAG1 Proteins) expression, which may have implications in Notch-mediated colon cancer progression
Inhibition of gamma-secretase in Notch1 signaling pathway inhibits proliferation and increased apoptosis in ovarian epithelial cancer cells.
Notch1 signaling may be required for ASIC1a (show ACCN2 Proteins)-mediated neurite growth and neuronal differentiation in neuroblastoma (show ARHGEF16 Proteins) cells.
Lower positive expression rate of RUNX3 (show RUNX3 Proteins) and higher positive expression rate of Notch1 and Jagged 1 (show JAG1 Proteins) were observed in CRC (show CALR Proteins) tissues than those in normal adjacent tissues with a negative correlation, and the expression levels were associated with the differentiation degree, TNM (show ODZ1 Proteins) staging, lymph node metastasis and tumor invasion depth (all P<0.05).
miR (show MLXIP Proteins)-139-5p downregulated NOTCH1 signaling to reverse CD44 (show CD44 Proteins)+/CD133+-associated MDR in colorectal cancer cells. Given this insight into the miRNA regulation of MDR, miR (show MLXIP Proteins)-139-5p could be a promising therapeutic target for colorectal cancer therapy.
High Notch1 expression, but not Numb (show NUMB Proteins) expression, is associated with favorable prognosis in small cell lung cancer.
we detected the hotspot c.7541_7542delCT NOTCH1 mutation in 17% of TP53 (show TP53 Proteins)-mutated patients and proved that both genes' defects preferentially affect the same CLL cells. In the NOTCH1-TP53 (show TP53 Proteins)-mutated patients we observed a marked clonal heterogeneity and therapy-related clonal evolution
Notch1 has a role in maintenance of stem-like cells in early tongue cancer
this paper shows the critical role of the Notch1-Hes1 signaling cascade in the regulation of innate immunity in acetaminophen-triggered liver inflammation
Data identified WISP-1 (show WISP1 Proteins) as a key downstream secretory mediator of Notch1 signaling to execute the influential role of MSC (show MSC Proteins)-DF on melanoma metastasis.
Taken together, these findings indicate that GAS5 may promote the progression of ischemic stroke through acting as a ceRNA for miR (show MLXIP Proteins)-137 to mediate the Notch1 signaling pathway, which contributes to an extensive understanding of ischemic stroke and may provide novel therapeutic options for this disease.
Data show that Wnt (show WNT2 Proteins) beta-Catenin (show CTNNB1 Proteins) signaling pathway activation followed by Notch inhibition strongly promotes the mitotic regeneration of new hair cell (HC) in both normal and neomycin-damaged cochleae.
Data suggest that Numb (show NUMB Proteins) acts as a Notch antagonist by controlling intracellular destination and stability of the Notch ligand (show JAG2 Proteins) Delta-like (show DLK1 Proteins) 4 (DLL4 (show DLL4 Proteins)) through a post-endocytic sorting process; Numb (show NUMB Proteins) negatively controls DLL4 (show DLL4 Proteins) plasma membrane recycling through well-documented recycling regulator protein AP1 (show JUN Proteins).
Data show that NOTCH1 is a target of ADAMTS1 (show ADAMTS1 Proteins) metalloproteinase activity, which reduces Notch signaling, leading to increased satellite cell activation.
Notch1 signaling is activated in brain endothelial cells cocultured with astrocytes, and astrocytic Jagged1 expression is required for angiogenic enhancement.
Sirt6 (show SIRT6 Proteins) inhibits Notch1 and Notch4 (show NOTCH4 Proteins) transcription by deacetylating histone H3K9.
Notch signaling is required for the formation of all nephron segments and it primes nephron progenitors for differentiation rather than directing their cell fates into a specific nephron segment.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
Notch signaling promotes floor plate and hypochord fates over notochord, but has variable effects on Shh (show SHH Proteins) expression in the midline.
Transgenic tadpoles were prepared with an elastase promoter driving either the stromelysin-3 (show MMP11 Proteins) gene or the constitutively active form of Notch (IC).
ZFP423 coordinates Notch1 and bone morphogenetic protein signaling, selectively up-regulating Hes5 (show HES5 Proteins) gene expression.
results suggest that a cell-to-cell interaction via the Notch/Su(H (show RBPJ Proteins)) pathway has a significant role in the PGC (show PGC Proteins) migration by regulating cell motility
the process of delimiting the three germ layers requires Notch signaling.
BCL6 (show BCL6 Proteins) inhibits transcription by competing for the Notch1 intracellular domain, preventing the coactivator Mastermind-like1 (MAM1 (show MAML1 Proteins)) from binding.
the combination of XSICD-mediated intracellular signaling and the extracellular domain of Notch ligands-mediated activation of Notch receptor is involved in the primary neurogenesis
Notch signaling is activated when activin-like signaling induces various tissues from homogenous undifferentiated cells.
Notch controls smad2 (show SMAD2 Proteins) nuclear localization and the competence of ectodermal cells for activin A (show INHBA Proteins) in Xenopus embryos
the NOTCH1 polymorphism g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height
bovine herpesvirus 1 ORF2 protein reduced the trans-activation potential of Notch1 and Notch3 (show NOTCH3 Proteins), suggesting that ORF2 interfered with the trans-activation potential of Notch.
Cellular size or Notch1 expression is not per se a specific marker for mesenchymal progenitor cells in adult articular cartilage.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
, Notch homolog 1, translocation-associated (Drosophila)
, Notch homolog 1, translocation-associated
, neurogenic locus notch homolog protein 1
, translocation-associated notch protein TAN-1
, Motch A
, Notch gene homolog 1
, major type A protein
, transmembrane receptor Notch1
, Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila)
, neurogenic locus notch protein homolog