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|Antigen||Forkhead Box L2 (FOXL2) Antibodies|
|Reactivity||Cow (Bovine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This FOXL2 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-FOXL2 AntibodyTarget Details FOXL2 Application Details Handling Images
|Specificity||This antibody detects FOXL2 at C-term.|
Species reactivity (expected):Mouse, Cow, Rat.
Species reactivity (tested):Human.
|Purification||Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide|
|Immunogen||Peptide from C Terminus of the protein sequence according to NP_075555.1 Genename: FOXL2|
Target Details FOXL2Product Details anti-FOXL2 Antibody Application Details Handling Images back to top
|Alternative Name||FOXL2 (FOXL2 Antibody Abstract)|
|Background||There are 2 forms of the blepharophimosis/ptosis/epicanthus inversus syndrome. In one form, called type I, eyelid abnormalities are associated with ovarian failure. In the second type, called type II, only the eyelid defects are found. Both types map to 3q23. Crisponi et al. (2001) refined the physical mapping of the BPES critical region and positionally cloned a novel, putative winged helix/forkhead transcription factor gene, FOXL2, in which they found mutations to produce truncated proteins in type I families and larger proteins in type II. Consistent with an involvement in those tissues, FOXL2 was selectively expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles, in adult humans, it appeared predominantly in the ovary.Synonyms: Forkhead box protein L2|
|Pathways||Nuclear Hormone Receptor Binding, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-FOXL2 Antibody Target Details FOXL2 Handling Images back to top
Peptide ELISA: Limit dilution 1: 16000. Western blot: 1-2 μg/mL. Approx 45-50 kDa band observed in Human Ovary extracts(predicted MW of 40 kDa according to NP_075555).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FOXL2 Antibody Target Details FOXL2 Application Details Images back to top
|Buffer||Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.|