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The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.
in the absence of MMS19, a failure to transfer Fe-S clusters to target proteins (show NCOA5 Proteins)is associated wi (show CIAO1 Proteins)th Fe- (show NARFL Proteins)S protein (show FAM96B Proteins)instability and preimplantation death of mice in which Mms19 has been knocked out; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair
Cloning of the mouse MMS19 genes and functional complementation in Saccharomyces cerevisiae
Mms19 has distinct and separable functions in nucleotide excision repair and cell growth
POLE1 is phosphorylated at serine-1940 after DNA damage and interacts with the iron-sulfur complex chaperones CIAO1 (show CIAO1 Proteins) and MMS19.
We therefore propose the expression level of MMS19 as a candidate predictive marker of ACT benefit in resected NSCLC patients.
Suggest that MMS19 may be a potential new predictor of metastasis and chemoradiotherapy response in esophageal squamous cell carcinoma.
MMS19L polymorphisms are associated with response to chemotherapy in osteosarcoma.
Single nucleotide polymorphisms in the MMS19L gene is associated with bone malignant tumors.
Polymorphisms in ERCC1 (show ERCC1 Proteins), codon-118 and MMS19 genes are not associated with clinical response to platinum or survival.
MMS19 interacts with target proteins. MIP18 (show FAM96B Proteins) has a role to bridge MMS19 and CIAO1 (show CIAO1 Proteins). CIAO1 (show CIAO1 Proteins) also binds IOP1 (show NARFL Proteins).
study demonstrates MMS19 forms a complex with the cytoplasmic Fe-S assembly (CIA (show ASF1A Proteins)) proteins CIAO1 (show CIAO1 Proteins), IOP1 (show NARFL Proteins) and MIP18 (show FAM96B Proteins); cytoplasmic MMS19 also binds to multiple nuclear Fe-S proteins involved in DNA metabolism; propose that MMS19 functions as a platform to facilitate Fe-S cluster transfer to proteins critical for DNA replication and repair
identified MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA (show ASF1A Proteins)) machinery; MMS19 functions as part of the CIA (show ASF1A Proteins) targeting complex that interacts with and facilitates iron-sulfur cluster insertion into apoproteins involved in methionine biosynthesis, DNA replication, DNA repair, and telomere maintenance
May play a role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription by interacting with ERCC2/XPD and ERCC3/XPB helicases, both subunits of NER- transcription factor TFIIH. May also function as a transcriptional coactivator of estrogen receptor (ER). May be involved in regulation of ER activity by bridging TFIIH with ER or may facilitate TFIIH-mediated phosphorylation of ER in specific promoters and cell types. As part of the mitotic spindle- associated MMXD complex it plays a role in chromosome segregation.
MMS19-like (MET18 homolog, S. cerevisiae)
, MET18 homolog
, MMS19 nucleotide excision repair protein homolog
, MMS19-like protein
, homolog of yeast MMS19