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enigma (show PDLIM1 Proteins) siRNA-transfected cells, cell viability, and the protein levels of AKT (show AKT1 Proteins) and survivin decreased.
Studies indicated that high survivin expression in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) was associated with poor overall survival [Review].
Nuclear accumulation of survivin is associated with proliferative phenotype and was shown to be a worse prognostic marker in breast ductal carcinoma.
Knockdown of BIRC5, a member of the inhibitor of apoptosis protein (show BIRC2 Proteins) family, using either lentiviral vector based CRISPR/Cas9 nickase gene editing or inhibition of survivin using the small-molecule inhibitor YM155, results in the suppression of epithelial to mesenchymal transition in retinal pigment epithelial cells.
By downregulation of Sp1 (show PSG1 Proteins) and survivin at the late phase of treatment.
The expressions of survivin and STAT2 (show STAT2 Proteins) are up-regulated in skin lesions of PV patients, and their mRNA expressions are positively correlated.
Findings suggest that lysosome-associated transmembrane protein 4B (LAPTM4B), vascular endothelial growth factor (VEGF (show VEGF Proteins)), and nuclear survivin expression are significantly correlated in breast cancer, which may be predictive of prognosis as well as effective therapeutic targets for anticancer therapies.
HIF-2alpha (show EPAS1 Proteins) dictates the resistance of human pancreatic cancer cells to TRAIL under normoxic and hypoxic conditions and transcriptionally regulates survivin expression.
survivin may have a role in recurrence in rectal cancer patients treated with surgery and postoperative concurrent chemo-radiation therapy
Results identified BIRC5 to be significantly upregulated in the lung squamous cell carcinoma tissues of smoking patients and may play an important role in diagnosis and prognosis.
The present results indicated that PPARgamma (show PPARG Proteins) may serve a protective role on bEnd.3 cells and that BIRC5 may be a downstream target of PPARgamma (show PPARG Proteins) regulation during cerebral ischemia.
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL (show HSD11B1 Proteins)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 (show STAT3 Proteins) activity and survivin expression.
Survivin also attenuates DNA damage related to PARP (show PARP1 Proteins) activation and inhibits TNFalpha (show TNF Proteins)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (show TGFB1 Proteins) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (show GUSB Proteins) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 Proteins) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Proteins)) cancer stem cell formation and cancer SCC (show CYP11A1 Proteins) development.
The present studies aim to examine whether and how cilia function (Pkd1 (show PKD1 Proteins) or Pkd2 (show PKD2 Proteins)) and structure (Tg737 (show IFT88 Proteins)) play a role in cystic kidney and aneurysm through survivin downregulation.
Survivin 1 was identified as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis.
the Aurora B (show AURKB Proteins) chromosome passenger protein complex, including INCENP (show INCENP Proteins) and survivin, is regulated during oocyte maturation in Xenopus laevis
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)
, apoptosis inhibitor 4
, survivin variant 3 alpha
, survivin 1
, Survivin 2
, baculoviral IAP repeat-containing 5, gene 2
, baculoviral IAP repeat-containing protein 5.2