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Concomitant high expression of survivin and VEGF-C (show VEGFC Proteins) is closely associated with LNM status of PTC (show F9 Proteins) patients, which suggests their cooperation in the metastatic process.
In leukoplakia, the expression of survivin associated with that of ki-67 (show MKI67 Proteins) reinforces the assumption that all these lesions are potentially malignant.
Study showed for the first time that the suppression of rheumatiod arthritis fibroblast-like synoviocyte was mediated by phosphatase and tensin homolog involving survivin silencing.
ERCC1 (show ERCC1 Proteins) expression may also inhibit esophageal squamous cell carcinoma cell apoptosis via regulating survivin expression, and ERCC1 (show ERCC1 Proteins) and survivin overexpression are independent predictors of prognosis for ESCC patients who receive chemotherapy and/or radiotherapy
let-7b targets PLK1 to inhibit hepatocellular carcinoma cell growth and induce their apoptosis by attenuating the PLK1-mediated Survivin phosphorylation
Overexpression of Survivin in glioma cells induces chromosomal instability
results demonstrated that PLAUR (show PLAUR Proteins) induces geftinib-resistance through EGFR (show EGFR Proteins)/p-AKT (show AKT1 Proteins)/survivin signaling pathway in gefitinib-resistant human lung adenocarcinoma cells. PLAUR (show PLAUR Proteins) could be a novel therapeutic target for gefitinib-resistant NSCLC patients.
High BIRC5 expression is associated with ovarian cancer.
In III-rd trimester of pregnancy parameters of Timp-1 (show TIMP1 Proteins) and Survivin - anti-apoptotic substances concentration were similar in maternal and cord blood in both artery and vein. We found no increased activity of selected antiapoptotic factors.
Results form study in non-small-cell lung cancer cells showed that SphK2 (show SPHK2 Proteins) plays a critical role in doxorubicin-induced resistance by regulating key anti-apoptotic gene, survivin.
The present results indicated that PPARgamma (show PPARG Proteins) may serve a protective role on bEnd.3 cells and that BIRC5 may be a downstream target of PPARgamma (show PPARG Proteins) regulation during cerebral ischemia.
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL (show HSD11B1 Proteins)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 (show STAT3 Proteins) activity and survivin expression.
Survivin also attenuates DNA damage related to PARP (show PARP1 Proteins) activation and inhibits TNFalpha (show TNF Proteins)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (show TGFB1 Proteins) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (show GUSB Proteins) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (show WNT2 Proteins) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (show CYP11A1 Proteins)) cancer stem cell formation and cancer SCC (show CYP11A1 Proteins) development.
The present studies aim to examine whether and how cilia function (Pkd1 (show PKD1 Proteins) or Pkd2 (show PKD2 Proteins)) and structure (Tg737 (show IFT88 Proteins)) play a role in cystic kidney and aneurysm through survivin downregulation.
Survivin 1 was identified as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis.
the Aurora B (show AURKB Proteins) chromosome passenger protein complex, including INCENP (show INCENP Proteins) and survivin, is regulated during oocyte maturation in Xenopus laevis
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)
, apoptosis inhibitor 4
, survivin variant 3 alpha
, survivin 1
, Survivin 2
, baculoviral IAP repeat-containing 5, gene 2
, baculoviral IAP repeat-containing protein 5.2