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UIMC1 Proteins

(Ubiquitin Interaction Motif Containing 1 (UIMC1))

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B\; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).

recommended

UIMC1 Protein (AA 1-385) (GST tag) (ABIN1324614)

UIMC1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP

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recommended

UIMC1 Protein (AA 1-719) (Strep Tag) (ABIN3096257)

Crystallography grade UIMC1 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS

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recommended

UIMC1 Protein (AA 1-726) (His tag) (ABIN1634738)

UIMC1 Origin: Rat Host: Yeast Recombinant > 90 % ELISA

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UIMC1 Proteins by Grade

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UIMC1 Proteins by Origin

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UIMC1 Proteins by Source

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UIMC1 Proteins by Protein Type

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UIMC1 Proteins by Application

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Popular UIMC1 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

UIMC1 Protein (AA 1-385) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1324614

Quantity 10 μg

Datasheet Datasheet

UIMC1 Protein (AA 1-719) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3096257

Quantity 1 mg

Datasheet Datasheet

UIMC1 Protein (AA 1-726) (His tag)

Reactivity Rat

Source Yeast

Validations

Cat. No. ABIN1634738

Quantity 1 mg

Datasheet Datasheet

Aliases for UIMC1 Proteins

ubiquitin interaction motif containing 1 (UIMC1) Proteins
ubiquitin interaction motif containing 1 (Uimc1) Proteins
9430016E08Rik Proteins
D330018D10Rik Proteins
D630032M02Rik Proteins
RAP80 Proteins
RGD1307009 Proteins
RIP110 Proteins
Rxrip110 Proteins
UIMC1 Proteins
X2HRIP110 Proteins

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UIMC1 Proteins by Grade

UIMC1 Proteins by Origin

UIMC1 Proteins by Source

UIMC1 Proteins by Protein Type

UIMC1 Proteins by Application

Popular UIMC1 Proteins

Aliases for UIMC1 Proteins

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