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Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
although esr2b mutant fish showed unaltered antibacterial responses, they were unable to mount an effective antiviral response upon viral challenge.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha (show ESR1 Proteins), and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor (show ESR1 Proteins) subtypes in a true physiological context.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha (show ESR1 Proteins) and ER beta after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1 (show ESR1 Proteins), ERalpha (show ESR1 Proteins); esr2b, ERbeta1; and esr2a (show ESR1 Proteins), ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha (show ESR1 Proteins), beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha (show ESR1 Proteins), ERbeta-A and ERbeta-B (show ESR1 Proteins) and induces apoptosis in an ER-independent manner
Estradiol can weakly modulate the motility and this effect is strictly associated with GPER and not with ESR1 and ESR2. The subcellular localization of GPER in the neck on stallion sperm is coherent with this effect.
The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
expression of estrogen receptor alpha (show ESR1 Proteins) and beta and progesterone receptor (show PGR Proteins) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
cloned three ER subtypes (ERalpha (show ESR1 Proteins), ERbeta1, and ERbeta2), and examined their developmental expression in the gonads of females and males during embryonic and larval development
The expression of androgen receptors, estrogen receptor beta, and bone morphogenetic protein 2b (show BMP4 Proteins) in male and female Japanese and Thai medaka are reported.
Taken together, the above results clearly demonstrated an mTORC2 (show CRTC2 Proteins)-dependent regulation of actin polymerization that contributed to the effects of ERalpha (show ESR1 Proteins) and ERbeta on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
Results provide evidence that ERbeta prevents cardiac fibroblasts to undergo fibrosis development.
Increased DNA methylation (show HELLS Proteins) accompanied this pattern, particularly at CpG dinucleotides located within binding or flanking regions for the transcriptional regulator CCCTC-binding factor (show CTCF Proteins) of ESR1 (show ESR1 Proteins) and ESR2, consistent with sustained transcriptional activation of ERa and ERb
These data highlight a new role for ER-beta in adipose biology and its potential to be a safer alternative peripheral therapeutic target for obesity.
Results indicated that puerarin is neuroprotective against Abeta1-42 toxicity via the activation of estrogen receptors, and ERbeta plays a key role in the process. Rindings provide a potential strategy for the prevention of neurodegeneration and the treatment of Alzheimer's disease.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta and the G protein-coupled estrogen receptor (show ESR1 Proteins).
The present results showed that ER knockout alpha and beta male mice had lower striatal mGlu5 (show GRM5 Proteins) receptor binding and protein measured by Western blot.
Kiss1 (show KISS1 Proteins) in the medial amygdala is regulated primarily by estrogen receptor alpha (show ESR1 Proteins), and not estrogen receptor beta.
ER-alpha (show ESR1 Proteins) plays a more critical role in promoting adipose-derived stem cells proliferation and migration while ER-beta is more potent in suppressing adipose-derived stem cells brown adipose tissue differentiation mediated by decreased UCP-1 (show UCP1 Proteins), PGC-1alpha and PPAR (show PPARA Proteins)-x03B3; expression.
ERa and ERb activation reduce TJ disruption via inhibition of signaling molecules after ischemic injury and that targeting each ER subtype can be a useful strategy for protecting the BBB from ischemic stroke in postmenopausal women
ERbeta plays a crucial role in the cell behavior and extracellular matrix composition of the highly aggressive MDA-MB-231 cells.
Study provides evidence for a critical role of ESR2 in radio-resistance of in head and neck squamous cell carcinoma, and that SMR3A (show SMR3A Proteins) might serve as a surrogate marker for active ESR2 signaling.
This study demonstrated that ESR2 but not ESR1 (show ESR1 Proteins) minor alleles were associated with lower cognitive performance in elderly women with an indication of a gene-gene interaction with APOEepsilon4. And also found indications for gene-environment interactions of ESR2 with traffic-related air pollution exposure on cognitive performance.
LY500307 is a highly selective estrogen receptor beta agonist, which loses its selectivity at high dose and leads to undesirable suppression of total testosterone concentration.
ERbeta ubiquitination, protein turnover, and inhibition of breast cancer is regulated by tyrosine phosphorylation
ERbeta in both normal and cancerous colon epithelial cells upregulates miRNA-205, which subsequently reduces PROX1 through direct interaction with its 3'UTR
Membrane estrogen receptor beta and GPER signaling mediate cellular responses to environmentally relevant concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells.
C-Jun (show JUN Proteins) and CREB (show CREB1 Proteins) are recruited to ESR2 or CYP19A1 (show CYP19A1 Proteins) promoter by IGF-I (show IGF1 Proteins) stimulation.
increases in ERbeta and p53 (show TP53 Proteins) immunoreactivity were significantly correlated with the incidence of metastasis and/or recurrence in endometrial endometrioid carcinoma
Low estrogen receptor beta is associated with triple-negative breast cancer.
There were no statistical differences between the BB genotype and the AB genotype of ESR2 locus in regard to the examined traits. However, a noticeable superiority (P < 0.01) of the BB genotype compared to the homozygous AA genotype, adding almost 2 piglets/litter in TNB and NBA trait, was found.
steroid hormones, AhR (show AHR Proteins) and estrogen receptor beta are affected by TCDD and genistein in granulosa cells of medium porcine follicles
Results suggest that expression levels of protease activated receptors 1 and 2 (PAR-1 (show F2R Proteins) and PAR-2 (show F2RL1 Proteins)) associate with breast cancer outcome in an estrogen receptor (ER (show ESR1 Proteins))-dependent manner.
results might shed new light on the roles of estrogen receptor (show ESR1 Proteins) 2(ESR2) in spermatogenesis as candidate for boar fertility
Downregulation of the ERs, particularly ERalpha (show ESR1 Proteins) in the myometrium and endometrial stroma, might be a relevant mechanism in the antagonism of estrogenic effects by dihydrotestosterone in the pig uterus.
the results of the present study suggest the involvement of estrogen receptor beta in estrogen modulation of pig epididymal function
ERbeta mRNA was found only in Sertoli cells in the testis.
positive staining for ERalpha (show ESR1 Proteins) in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
ESR2 gene polymorphisms are associated with litter size.
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 (show ESR1 Proteins) and ESR2) and to analyze the effects of these variants and the well known intronic ESR1 (show ESR1 Proteins) PvuII polymorphism on litter size.
The mRNA expression of ER-alpha (show ESR1 Proteins) and ER-beta in the hypothalamus of developing male and female bovines, is reported.
ER-alpha (show ESR1 Proteins) is detected predominantly in the soma whereas ER-beta is only present in the nucleus of a few cells in the frontal cortex.
fetal ovary of cattle has the steroidogenic enzyme aromatase (show CYP19A1 Proteins) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha (show ESR1 Proteins), ERbeta and PR in bovine oviducts at different cycle stages in vivo
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (show SNRPB Proteins)) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha (show TNF Proteins) and IFNgamma regulate ERalpha (show ESR1 Proteins) and ERbeta mRNA expressions in bovine luteal cells.
Roles of IGF-I (show IGF1 Proteins) and the estrogen, androgen and IGF-I (show IGF1 Proteins) receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
The main functional structure domains of the ESR2 in a Jining Gray female goat have been described.
an 17b-estradiol-induced increase in the proliferation of rhesus retinal capillary endothelial cells may be mediated by the action of ERb.
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
, estrogen receptor beta1
, estrogen receptor beta
, estrogen receptor 2 (ER beta)
, estradiol receptor beta
, estrogen receptor beta 2
, estrogen receptor beta 1
, Nuclear receptor subfamily 3 group A member 2
, estrogen receptor beta-like
, ER beta
, nuclear receptor subfamily 3 group A member 2
, oestrogen receptor beta
, estrogen nuclear receptor beta variant a
, estrogen nuclear receptor beta variant b
, estrogen receptor beta 4
, estrogen receptor 2 beta
, steroid receptor
, estrogen receptor 2 (beta)