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It was also associated with beta-cell function (P=1.99 x 10(-3)) and fasting glucose level (P<0.05) in the meta-analyses of glucose and insulin (show INS Proteins)-related traits consortium (MAGIC) data set.Cnoclusions:In summary, we identified epigenomic characteristics for obesity genes and suggested ESRRG as a novel obesity-susceptibility gene
this study elucidates a molecular mechanism linking CB1R signaling, ERRgamma expression and fibrinogen gene transcription.
Disruption of the orphan receptor (show NR1D2 Proteins) ESRRG and disruption of KIAA0825 identified in a subject with hearing loss and mild developmental delay. Given the translocation breakpoints and supporting literature, disruption of ESRRG is the most likely cause for the disorder.
Data suggest that activation of ERRgamma is involved in induction of matrix metalloproteinases 2/9 (MMP2 (show MMP2 Proteins) and MMP9 (show MMP9 Proteins)) and increased migration/invasiveness of triple-negative breast cancer cells caused by low concentrations of environmental endocrine disruptors (nanomolar bisphenol A used here).
The present results strongly suggest that human nuclear receptor ERRgamma functions as a genuine homomeric dimer with symmetrical dimeric interface regions.
ERRgamma overexpression directs metabolic maturation in human Induced Pluripotent Stem Cells-derived beta-l (show INS Proteins)ike cells.
Estrogen-related receptor gamma is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 (show CDKN1A Proteins) and p27 (show PAK2 Proteins).
Data show that micrRNA miR-320a directly targets cAMP-regulated phosphoprotein 19 (ARPP-19) and estrogen-related receptor gamma protein (ERRgamma) in breast cancer cell lines.
ERRgamma signaling is associated with poor DMFS in ER+, TAM (show CCNA1 Proteins)-treated breast cancer
ESRRG is down-regulated in placenta from intrauterine growth restriction tissue.
These findings strongly support a role for ERRgamma in the metabolic alterations that underlie the development of diabetic cardiomyopathy.
our results reveal that ERRgamma, induced via activation of the hepatic CB1 (show CNR1 Proteins) receptor, is a regulator of hepatic FGF21 (show FGF21 Proteins) gene expression and secretion.
Study conclude that O-GlcNAcylation of ERRgamma serves as a major signal to promote hepatic gluconeogenesis.
Mice deficient in beta cell-specific ERRgamma expression are glucose intolerant and fail to secrete insulin (show INS Proteins) in response to a glucose challenge.
ERRgamma plays a key role in vascular calcification by upregulating the BMP2 (show BMP2 Proteins) signaling pathway.
Mice lacking neuronal ERRgamma in cerebral cortex and hippocampus exhibit defects in spatial learning and memory.
GSK5182 suppresses hypoxia-induced VEGF (show VEGFA Proteins) expression via ERRgamma; therefore, ERRgamma could be a treatment target for ischemic retinopathies
These results suggest that ERRgamma is a major contributor to insulin (show INS Proteins) action in maintaining hepatic glucose homeostasis.
ERRgamma is a sexdependent and RUNX2 (show RUNX2 Proteins)-dependent negative regulator of osteoblast differentiation, and that its regulatory activity may also be differentiation stage-dependent.
Mice lacking both ERRalpha (show ESRRA Proteins) and cardiac Errg develop severe bradycardia, lethal cardiomyopathy, and heart failure featuring metabolic, contractile, and conduction dysfunctions.
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors\; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.
, estrogen-related receptor beta/gamma
, estrogen-related receptor gamma
, Usher syndrome 2A (autosomal recessive, mild)
, estrogen-related receptor gamma type 1
, estrogen-related receptor gamma type 2
, estrogen-related receptor gamma-like
, ERR gamma-2
, estrogen receptor-related protein 3
, nuclear receptor subfamily 3 group B member 3
, estrogen-related receptor 3