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ESR1 inhibits the expression of Pitx2 gene by binding to a left side-specific enhancer region in Pitx2 gene and recruiting histone deacetylase 1 to this region, leading to the suppression of Pitx2 gene in the left lateral plate mesoderm.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.
deletion of AF-1 or AF-2 domains of ERalpha blocks pubertal ductal growth and subsequent development because both are required for expression of essential paracrine mediators.
findings suggest that ERalpha promotes beta-cell survival and insulin secretion through maintenance of mitochondrial fission/fusion-mitophagy dynamics and EndoRetic function, in part by Oma1 and Chop repression.
Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted from adjacent stromal cells. Moreover, loss of stromal ESR1 caused mice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus.
we demonstrate that in the presence of E2, NKB signaling induces LH release in a kisspeptin-independent manner through the activation of NK3R (NKB receptor) neurons in the posterodorsal medial amygdala (MePD). Importantly, we show that chemogenetic activation of MePD Kiss1 neurons induces LH release, however, the stimulatory action of NKB in this area is Kiss1 neuron-independent.
sex hormone receptors, estrogen receptor alpha (ERalpha) and androgen receptor (AR), mediate sexually dimorphic gene expression in mouse livers.
Data suggest that loss of ERalpha signaling blocks the influence of maternal high-fat diet (HFD) on energy homeostasis, inflammation, and hypothalamic and liver gene expression and that restoration of estrogen response elements-independent ERalpha signaling partially reestablishes susceptibility to maternal HFD.
Study compared age and tissue- specific methylation differences in the brain and spleen of young and aged mice. There were 75 hypermethylated Foxa2 binding sites across a 2.7 Mb region of chromosome 11. Hypomethylated loci were clustered around Mid1, Isoc2b and genome-wide loci with binding sites for Foxa2 and Esr1, which are known to play important roles in development and aging.
ERalpha-expressing Kiss1 arcuate nucleus neurons are central to restraining a powerful brain-bone axis in female mice.
Divergent roles of ERalphaAF-1 and ERalphaAF-2 in E2 and SERM-mediated modulation of bone marrow B lymphopoiesis were found.
Effects of low-magnitude high-frequency vibration on osteoblasts are dependent on estrogen receptor alpha signaling and cytoskeletal remodeling.
The authors identify estrogen receptor alpha (ERalpha) as the top regulator of pro-resilient transcriptional changes in the nucleus accumbens, a key brain reward region implicated in depression.
ERalpha-signaling may be crucial for vibration-induced effects on fracture healing, whereas ERbeta-signaling may play a minor role
hepatic Estradiol/ESR1 signaling plays a key role in the maintenance of gluconeogenesis and lipid metabolism in males.
ESR1 inhibits chorionic gonadotropin-induced steroidogenesis and proliferation of progenitor Leydig cells in mice.
suppresses breast cancer metastasis by regulating vinculin
High ESR1 expression is associated with metastasis in breast Cancer.
Study demonstrates an unexpected phenotype in high fat diet-fed estrogen receptor alpha (ERalpha) knockout mice involving severe uterine bacterial infections likely resulting from a previously unknown negative interference between dietary fatty acids and ERalpha-signaling during anti-microbial defence.
study found that 27-HC promoted the growth of melanoma cells by activating ERalpha and eliciting the AKT and MAPK signaling pathway.
By using mutant mice with liver-specific ablation of Eralpha, the authors here demonstrate that the hepatic ERalpha is essential for the modulation of the activity of Agouti Related Protein (AgRP) neurons in relation to the reproductive cycle and diet.
DNA methylation and transcriptome aberrations mediated by ERalpha in mouse seminal vesicles following developmental DES exposure.
The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.
expression of estrogen receptor alpha and beta and progesterone receptor in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.
study is the first one to demonstrate the presence of estrogen receptors alpha and beta in the porcine uterus not only at the beginning but also at mid- and late pregnancy
findings suggest that testicular estrogen receptors alpha and beta may be important factors contributing to onset and maintenance of spermatogenesis in the boar.
Results showed that the effects of FSHb, ESR, and PRLR genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII and stage I of the seminiferous epithelial cycle, but not in other cells.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.
Pig ejaculated spermatozoa express estrogen receptor.
The expression of mRNAs for ERalpha, ERbeta and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
Report stable reporter gene assays based on stable expression of subtypes of zebrafish ER (zfERalpha, zfERbeta1, and zfERbeta2) coupled to estrogen response element-driven luciferase in a zebrafish liver cell line.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b, ERbeta1; and esr2a, ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A and ERbeta-B and induces apoptosis in an ER-independent manner
our results here suggest that there is a negative correlation between bta-miR-222 and ER-alpha expression during follicular development in cow ovaries.
The mRNA expression of ER-alpha and ER-beta in the hypothalamus of developing male and female bovines, is reported.
Distribution of estrogen receptor alpha and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
ER-alpha is detected predominantly in the soma whereas ER-beta is only present in the nucleus of a few cells in the frontal cortex.
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha, ERbeta and PR in bovine oviducts at different cycle stages in vivo
ER may play a role in the rapid effects of resveratrol in EC and some of the atheroprotective effects of resveratrol may be mediated through rapid activation of ER signaling in EC
estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha and IFNgamma regulate ERalpha and ERbeta mRNA expressions in bovine luteal cells.
The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
The TT (timin/timin) genotype for the ESR1 (rs2273206) gene was strongly associated with the risk of developing muscle TMDs and temporomandibular joint pain (P = .04).
We confirmed the co-expression of RET and ER, but we did not find RET expression to be an independent prognostic factor in human breast cancer
Study identified consensus binding motifs for the bile acid-responsive FXR in the BRCA1 and estrogen receptors 1 and 2 (ESR1 and ESR2) genes. Bile acids treatment resulted in induction of BRCA1 transcript levels and decrease in ESR1 expression in OVCAR3 ovarian cancer cells.
High ERalpha expression was associated with improved survival in ovarian cancer patients.
These results suggest the interplays of ESR1 rs2234693 with post-traumatic stress disorder influence serum glucose and lipids profiles with a gender dependent manner.
Relative to ER, PR and HER2 from medical records, central IHC staining and the addition of Ki67 or combined tumor grade improved accuracy for classifying PAM50-based luminal subtypes.
the observed complex formation between SMYD2 and HSP90/P23 may contribute to ERalpha regulation.
HER2 amplification is a distinct driver event seen in all breast cancer subtypes, rather than a subtype marker, with major characteristics restricted to amplification and overexpression of HER2 and neighboring genes. The HER2E subtype has a distinctive transcriptional landscape independent of HER2A that reflects androgen receptor signaling as replacement for estrogen receptor (ER)-driven tumorigenesis.
The unexpected signature for estradiol-induced program resides in indirect recruitment of ERa to a large cohort of basally active FOXA1-bound enhancers that lack cognate ERa DNA-binding elements.
we found that the control groups of rs746432 deviated from HWE (P < 0.05), which led to an unconvincing conclusion about the association between rs746432 polymorphism and the risk of breast cancer.
Genome-wide ER-alpha activation is sustained, not cyclical.
This meta-analysis indicated that the ERalpha PvuII polymorphism was significantly associated with systemic lupus erythematosus susceptibility in the overall and Asian populations, while the ERalpha XbaI GA genotype only played a key role in systemic lupus erythematosus susceptibility in Asian populations.
The XbaI single nucleotide polymorphism in the estrogen receptor alpha contributes to tendinopathy in postmenopausal women.
Study determined that the expression of miR1075p in endometrial carcinoma (EC) was significantly higher than that in normal endometrium, and higher miR1075p expression was related to advanced stages, lymph node metastasis and myometrial invasion. The results of bioinformatic algorithms and luciferase reporter assays in human endometrial cancer cell lines revealed that ERalpha was a direct target of miR1075p.
Via a feedback loop involving miR-375, RASD1, and ERalpha.
Up-regulates expression of GREB1 in ovarian cancer
Identification of SEPTIN12 as a novel target of the androgen and estrogen receptors in human testicular cells.
Role of SUMOylation in differential ERalpha transcriptional repression by tamoxifen and fulvestrant in breast cancer cells.
role of cystatin A in breast cancer and its functional link with ERalpha
Results provide evidence that the PvuII and XbaI polymorphisms in ESR1 gene are not related to development of central precocious puberty.
This study investigetes the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors.
The ERalpha1 sequence was the longest and the only one of the four ER isoforms that contained multiple copies of the canonical AU-rich elements (AUUUA) as well as the stability sequence (GCUGAU).
synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance
It is a lactogenic gene. Mammary epithelial cells respond to lactogenic condition by up-regulation of the gene.
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
estrogen receptor alpha 1
, estradiol receptor
, estrogen receptor
, nuclear receptor subfamily 3 group A member 1
, estrogen receptor alpha
, estrogen receptor, alpha
, estrogen nuclear receptor alpha
, estrogen receptor alpha 3*,4,5,6,7*/822 isoform
, estrogen receptor alpha E1-E2-1-2
, estrogen receptor alpha E1-N2-E2-1-2
, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
, estrogen receptor alpha delta 4 +49 isoform
, estrogen receptor alpha delta 4*,5,6,7*/654 isoform
, estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
, Er alpha
, estrogen receptor 1 (alpha)
, estrogen receptor alpha variant delta 4
, estrogen receptor protein
, estrogen receptor 1
, nuclear receptor
, Estradiol receptor
, Nuclear receptor subfamily 3 group A member 1
, estrogen alpha receptor