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ESR1 inhibits the expression of Pitx2 (show PITX2 Proteins) gene by binding to a left side-specific enhancer region in Pitx2 (show PITX2 Proteins) gene and recruiting histone deacetylase 1 (show HDAC1 Proteins) to this region, leading to the suppression of Pitx2 (show PITX2 Proteins) gene in the left lateral plate mesoderm.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.
ESR1 inhibits chorionic gonadotropin-induced steroidogenesis and proliferation of progenitor Leydig cells in mice.
suppresses breast cancer met (show VCL Proteins)astasis by regulating vinculin
High ESR1 expression is associated with metastasis in breast Cancer.
Study demonstrates an unexpected phenotype in high fat diet-fed estrogen receptor alpha (ERalpha) knockout mice involving severe uterine bacterial infections likely resulting from a previously unknown negative interference between dietary fatty acids and ERalpha-signaling during anti-microbial defence.
study found that 27-HC promoted the growth of melanoma cells by activating ERalpha and eliciting the AKT (show AKT1 Proteins) and MAPK (show MAPK1 Proteins) signaling pathway.
By using mutant mice with liver-specific ablation of Eralpha, the authors here demonstrate that the hepatic ERalpha is essential for the modulation of the activity of Agouti Related Protein (AgRP (show AGRP Proteins)) neurons in relation to the reproductive cycle and diet.
DNA methylation (show HELLS Proteins) and transcriptome aberrations mediated by ERalpha in mouse seminal vesicles following developmental DES (show DES Proteins) exposure.
This novel transgenic mouse line will be a useful animal model for lineage-tracing Esr1-expressing cells, selective gene ablation in the Esr1-lineage cells and for generating global Esr1 knockout mice.
Data (including data from studies in transgenic mice) suggest that Esr1 signaling promotes activation of Pp2a; here, central activation of Pp2a during estrogen replacement therapy is involved in prevention of menopause-induced obesity and glucose intolerance (that is, induced by lack of membrane-initiated Esr1 signaling). (Esr1 = estrogen receptor 1; Pp2a = protein phosphatase 2A)
Results show that membrane initiated ERalpha signaling is important for the estrogen response in adult female mice in vivo in a tissue-dependent manner, and that membrane ERalpha signaling is crucial for the estrogen response in trabecular bone in the axial skeleton.
The presence of a single isoform of ESR1 (66kDa (show SF3A2 Proteins)) and ESR2 (show ESR2 Proteins) (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER (show GPER Proteins) in colt testis.
The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.
expression of estrogen receptor alpha and beta and progesterone receptor (show PGR Proteins) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.
Results showed that the effects of FSHb (show FSHB Proteins), ESR, and PRLR (show PRLR Proteins) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII (show COX8A Proteins) and stage I of the seminiferous epithelial cycle, but not in other cells.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta (show ESR2 Proteins) stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 (show ESR2 Proteins)) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta (show ESR2 Proteins) activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.
Pig ejaculated spermatozoa express estrogen receptor.
The expression of mRNAs for ERalpha, ERbeta (show ESR2 Proteins) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta (show ESR2 Proteins) after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b (show ESR2 Proteins), ERbeta1; and esr2a, ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A (show ESR2 Proteins) and ERbeta-B and induces apoptosis in an ER-independent manner
The mRNA expression of ER-alpha and ER-beta (show ESR2 Proteins) in the hypothalamus of developing male and female bovines, is reported.
Distribution of estrogen receptor alpha and progesterone receptor (show PGR Proteins) B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
ER-alpha is detected predominantly in the soma whereas ER-beta (show ESR2 Proteins) is only present in the nucleus of a few cells in the frontal cortex.
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
fetal ovary of cattle has the steroidogenic enzyme aromatase (show CYP19A1 Proteins) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha, ERbeta (show ESR2 Proteins) and PR in bovine oviducts at different cycle stages in vivo
estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (show SNRPB Proteins)) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha (show TNF Proteins) and IFNgamma regulate ERalpha and ERbeta (show ESR2 Proteins) mRNA expressions in bovine luteal cells.
The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
ER-alpha36/EGFR (show EGFR Proteins) signaling loop promotes growth of hepatocellular carcinoma cells
This study aimed to determine the presence and localization of oestrogen receptors (ERs), progesterone receptors (PRs), and androgen receptors (ARs (show SLURP1 Proteins)) in both healthy and varicose vein wall cells and their relationship with gender.
Estrogen receptor-alpha was expressed only in women and showed a positive correlation with the amount of fungi in oral paracoccidioidomycosis, while progesterone receptor (show PGR Proteins) was observed in both genders and exhibited no correlation with estrogen receptor-alpha or fungi counting.
ERalpha upregulates vinculin (show VCL Proteins) expression in breast cancer cells; Loss of vinculin (show VCL Proteins) promotes amoeboid features of cancer cells
The G/G XbaI genotype of ESR1 gene is associated with breast cancer risk.
miR (show MLXIP Proteins)-221 may impair the protective effect of estrogen in degenerated cartilaginous endplate cells through targeting estrogen receptor alpha
Results showed that NAT1 (show EIF4G2 Proteins) and ESR1 expression were increased in primary breast tumor samples compared with normal breast tissue samples, and in ER+ primary breast tumors compared with ER- tumors. Also, NAT1 (show EIF4G2 Proteins) and ESR1 expression seems to have overlapping regulation.
all the patients without these mutations by molecular barcode next-generation sequencing (MB-NGS) were found to have no mutations by ddPCR. In conclusion, MB-NGS could successfully detect ESR1 mutations in cfDNA with a higher sensitivity of 0.1% than conventional NGS and was considered as clinically useful as ddPCR
In summary, an association between the presence of the particular genotypes at the three ESR1 polymorphisms (rs2234693, rs6902771, rs7774230) and one ESR2 (show ESR2 Proteins) polymorphism (rs3020449), and the presence of metabolic syndrome in postmenopausal women was found.
synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
estrogen receptor alpha 1
, estradiol receptor
, estrogen receptor
, nuclear receptor subfamily 3 group A member 1
, estrogen receptor alpha
, estrogen receptor, alpha
, estrogen nuclear receptor alpha
, estrogen receptor alpha 3*,4,5,6,7*/822 isoform
, estrogen receptor alpha E1-E2-1-2
, estrogen receptor alpha E1-N2-E2-1-2
, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
, estrogen receptor alpha delta 4 +49 isoform
, estrogen receptor alpha delta 4*,5,6,7*/654 isoform
, estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
, Er alpha
, estrogen receptor 1 (alpha)
, estrogen receptor alpha variant delta 4
, estrogen receptor protein
, estrogen receptor 1
, nuclear receptor
, Estradiol receptor
, Nuclear receptor subfamily 3 group A member 1
, estrogen alpha receptor