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The administration of ICI182,780, which is an agonist of G-protein coupled estrogen receptor (GPER) and an antagonist of ERa and ERb (show ESR2 Proteins), did not result in protection; however, ICI182,780 significantly blocked EDC-mediated cardioprotection, indicating participation of ERalpha and/or ERbeta (show ESR2 Proteins)
Data (including data from studies using knockout mice) suggest that early initiation of endometriosis is predominantly dependent on immune system; cross-talk occurs between Esr1 and Il6 (show IL6 Proteins) pathways during early initiation of endometriosis lesion development; estradiol stimulation of Esr1 appears to play minor role in early lesion development. (Esr1 = estrogen receptor alpha; Il6 (show IL6 Proteins) = interleukin 6 (show IL6 Proteins))
Studies indicate that lack of estrogen receptor alpha (ERalpha) in osteoblast progenitor and precursor cells generally affects the periosteum of female and male mice.
Transgenic mouse line expressing the human Ki-Ras bearing an activating mutation (Ki-Ras((G12V))) selectively in the mammary epithelium develop estrogen receptor alpha (ERalpha)-positive ductal adenocarcinomas with 100% incidence within 3-9 months after Ki-Ras((G12V)) induction.
Lupus-prone ERalpha -/- mice are not protected from lupus disease expression if ovariectomized.
Taken together, the above results clearly demonstrated an mTORC2 (show CRTC2 Proteins)-dependent regulation of actin polymerization that contributed to the effects of ERalpha and ERbeta (show ESR2 Proteins) on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
These findings suggest that RASD1 (show RASD1 Proteins) acts as a novel signaling molecule and plays an important role in regulating dynamic uterine remodeling during the estrous cycle in the uterus.
Truncating mutations of Prlr (show PRLR Proteins) promote tumor growth in a model of human ERalpha+ breast cancer.
This comparative study documented the complexity of ERalpha genes, mRNAs, and proteins, and further determined the underlying structural basis of ligand-independent activation by C-terminally-truncated ERalpha variants.
E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C and natriuretic peptide receptor 2 (NPPC/NPR2 (show NPRL2 Proteins))
ESR1 inhibits the expression of Pitx2 (show PITX2 Proteins) gene by binding to a left side-specific enhancer region in Pitx2 (show PITX2 Proteins) gene and recruiting histone deacetylase 1 (show HDAC1 Proteins) to this region, leading to the suppression of Pitx2 (show PITX2 Proteins) gene in the left lateral plate mesoderm.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.
The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.
expression of estrogen receptor alpha and beta and progesterone receptor (show PGR Proteins) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.
Results showed that the effects of FSHb (show FSHB Proteins), ESR, and PRLR (show PRLR Proteins) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII (show COX8A Proteins) and stage I of the seminiferous epithelial cycle, but not in other cells.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta (show ESR2 Proteins) stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 (show ESR2 Proteins)) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta (show ESR2 Proteins) activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.
Pig ejaculated spermatozoa express estrogen receptor.
The expression of mRNAs for ERalpha, ERbeta (show ESR2 Proteins) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta (show ESR2 Proteins) after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b (show ESR2 Proteins), ERbeta1; and esr2a, ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A (show ESR2 Proteins) and ERbeta-B and induces apoptosis in an ER-independent manner
The mRNA expression of ER-alpha and ER-beta (show ESR2 Proteins) in the hypothalamus of developing male and female bovines, is reported.
Distribution of estrogen receptor alpha and progesterone receptor (show PGR Proteins) B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
ER-alpha is detected predominantly in the soma whereas ER-beta (show ESR2 Proteins) is only present in the nucleus of a few cells in the frontal cortex.
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
fetal ovary of cattle has the steroidogenic enzyme aromatase (show CYP19A1 Proteins) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha, ERbeta (show ESR2 Proteins) and PR in bovine oviducts at different cycle stages in vivo
estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (show SNRPB Proteins)) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha (show TNF Proteins) and IFNgamma regulate ERalpha and ERbeta (show ESR2 Proteins) mRNA expressions in bovine luteal cells.
The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
Patients with Estrogen- and progesterone receptors-positive invasive lobular carcinoma (ILC (show CCL27 Proteins)) and invasive ductal carcinoma (IDC (show LMNA Proteins))have similar quantitative ER and PR expression profiles, implicating that ER/PR expression is unlikely to be a confounding factor in studies concerning chemo-sensitivity of ILC (show CCL27 Proteins) and IDC (show LMNA Proteins)
Estrogen receptor-Src (show SRC Proteins) signaling plays an important role in ER (+) breast cancer, which shows a high potential for bone metastasis.
Folate deficiency impaired spermatogenesis and reduced sperm concentration may partly due to inhibiting the expression of the three key molecules (Esr1, Cav1 (show CAV1 Proteins) and Elavl1 (show ELAVL1 Proteins)) essential for sperm production.
the association between four ESR1 gene variants, and six ESR2 (show ESR2 Proteins) single nucleotide polymorphisms and breast cancer risk in Tunisian women
Ten international pathology institutions participated in this study and determined messenger RNA expression levels of ERBB2 (show ERBB2 Proteins), ESR1, PGR (show PGR Proteins), and MKI67 (show MKI67 Proteins) in both centrally and locally extracted RNA from formalin-fixed, paraffin-embedded breast cancer specimens with the MammaTyper(R) test. Samples were measured repeatedly on different days within the local laboratories, and reproducibility was assessed by means of variance comp (show COMP Proteins)...
These observations provide a tenable hypothesis for how D538G ESR1-expressing clones can contribute to shorter progression-free survival.
Combining ER and IGF1R (show IGF1R Proteins) targeting with HER2 (show ERBB2 Proteins) targeted therapies may be an alternative to HER2 (show ERBB2 Proteins) targeted therapy and chemotherapy for patients with HER2 (show ERBB2 Proteins)/ER/IGF1R (show IGF1R Proteins) positive breast cancer.
nhibition of miR (show MLXIP Proteins)-18a increases the expression of ER1 (show MIER1 Proteins) and promotes apoptosis in HTR8 human trophoblasts.
Taken together, ESR1 mutations in genome-edited breast cancer cell lines confer ligand-independent growth and endocrine resistance. These biologically relevant models can be used for further mechanistic and translational studies, including context-specific and mutation site-specific analysis of the ESR1 mutations.
Findings show that ESR1 selectively down-regulates HYAL1 (show HYAL1 Proteins) expression in breast cancer cells.
synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
, ERA-like GTPase
, ERA-like protein 1
, GTP-binding protein era homolog
, GTPase Era, mitochondrial
, conserved ERA-like GTPase
, estrogen receptor alpha 1
, estradiol receptor
, estrogen receptor
, nuclear receptor subfamily 3 group A member 1
, estrogen receptor alpha
, estrogen receptor, alpha
, estrogen nuclear receptor alpha
, estrogen receptor alpha 3*,4,5,6,7*/822 isoform
, estrogen receptor alpha E1-E2-1-2
, estrogen receptor alpha E1-N2-E2-1-2
, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
, estrogen receptor alpha delta 4 +49 isoform
, estrogen receptor alpha delta 4*,5,6,7*/654 isoform
, estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
, Er alpha
, estrogen receptor 1 (alpha)
, estrogen receptor alpha variant delta 4
, estrogen receptor protein
, estrogen receptor 1
, nuclear receptor
, Estradiol receptor
, Nuclear receptor subfamily 3 group A member 1
, estrogen alpha receptor