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ESR1 inhibits the expression of Pitx2 (show PITX2 Proteins) gene by binding to a left side-specific enhancer region in Pitx2 (show PITX2 Proteins) gene and recruiting histone deacetylase 1 (show HDAC1 Proteins) to this region, leading to the suppression of Pitx2 (show PITX2 Proteins) gene in the left lateral plate mesoderm.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.
Results show that ERalpha activation might constitute one of the neural substrate that is involved involved in the facilitative mechanisms to restore the sexual olfactory preferences of sexually naive Tph2 (show TPH2 Proteins)-/- female mice.
Study found that estrogen receptor alpha (ERalpha) was expressed in the motoneurons of lumbar ventral horn. ERalpha and ERbeta (show ESR2 Proteins) were mainly localized in the nuclei of motoneurons with less immunoreactivity in the cytoplasm.
suggest miR (show MLXIP Proteins)-181a inhibition enhances E2-mediated stroke protection in females in part by augmenting ERalpha production
nuclear Shp2 (show PTPN11 Proteins), rather than cytosolic Shp2 (show PTPN11 Proteins), promotes the ERalpha transcription activity. This function is achieved by enhancing the Src kinase (show CSK Proteins)-mediated ERalpha tyrosine phosphorylation, which facilitates ERalpha binding to Pgr (show PGR Proteins) promoter in an ERK (show EPHB2 Proteins)-independent manner in periimplantation uteri.
ERalpha masculinizes GABAergic neurons that gate the display of male-typical behaviors.
The administration of ICI182,780, which is an agonist of G-protein coupled estrogen receptor (GPER (show GPER Proteins)) and an antagonist of ERa and ERb (show ESR2 Proteins), did not result in protection; however, ICI182,780 significantly blocked EDC-mediated cardioprotection, indicating participation of ERalpha and/or ERbeta (show ESR2 Proteins)
Data (including data from studies using knockout mice) suggest that early initiation of endometriosis is predominantly dependent on immune system; cross-talk occurs between Esr1 and Il6 (show IL6 Proteins) pathways during early initiation of endometriosis lesion development; estradiol stimulation of Esr1 appears to play minor role in early lesion development. (Esr1 = estrogen receptor alpha; Il6 (show IL6 Proteins) = interleukin 6 (show IL6 Proteins))
Studies indicate that lack of estrogen receptor alpha (ERalpha) in osteoblast progenitor and precursor cells generally affects the periosteum of female and male mice.
Transgenic mouse line expressing the human Ki-Ras bearing an activating mutation (Ki-Ras((G12V))) selectively in the mammary epithelium develop estrogen receptor alpha (ERalpha)-positive ductal adenocarcinomas with 100% incidence within 3-9 months after Ki-Ras((G12V)) induction.
Lupus-prone ERalpha -/- mice are not protected from lupus disease expression if ovariectomized.
The presence of a single isoform of ESR1 (66kDa (show SF3A2 Proteins)) and ESR2 (show ESR2 Proteins) (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER (show GPER Proteins) in colt testis.
The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.
expression of estrogen receptor alpha and beta and progesterone receptor (show PGR Proteins) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.
Results showed that the effects of FSHb (show FSHB Proteins), ESR, and PRLR (show PRLR Proteins) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII (show COX8A Proteins) and stage I of the seminiferous epithelial cycle, but not in other cells.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta (show ESR2 Proteins) stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 (show ESR2 Proteins)) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta (show ESR2 Proteins) activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.
Pig ejaculated spermatozoa express estrogen receptor.
The expression of mRNAs for ERalpha, ERbeta (show ESR2 Proteins) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta (show ESR2 Proteins) after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b (show ESR2 Proteins), ERbeta1; and esr2a, ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A (show ESR2 Proteins) and ERbeta-B and induces apoptosis in an ER-independent manner
The mRNA expression of ER-alpha and ER-beta (show ESR2 Proteins) in the hypothalamus of developing male and female bovines, is reported.
Distribution of estrogen receptor alpha and progesterone receptor (show PGR Proteins) B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
ER-alpha is detected predominantly in the soma whereas ER-beta (show ESR2 Proteins) is only present in the nucleus of a few cells in the frontal cortex.
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
fetal ovary of cattle has the steroidogenic enzyme aromatase (show CYP19A1 Proteins) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha, ERbeta (show ESR2 Proteins) and PR in bovine oviducts at different cycle stages in vivo
estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (show SNRPB Proteins)) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha (show TNF Proteins) and IFNgamma regulate ERalpha and ERbeta (show ESR2 Proteins) mRNA expressions in bovine luteal cells.
The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
We demonstrated the presence of a distinct population of ESR1 LBD mutations (E380Q, Y537S, Y537N, Y537C, and D538G) in metastatic tissue and plasma using ddPCR assay.
Further study revealed AP000439.3 can regulate expression of CCND1 (show CCND1 Proteins) through enhancing estrogen receptor induction of CCND1 (show CCND1 Proteins). This finding revealed lncRNAs may serve as important effectors of ER in regulation of gene expression and cell phenotype in breast cancer
Functional enrichment analysis of DEGs (show DEGS1 Proteins) indicated their potential involvement in cancer, and cell activity-related processes. Fifteen overlaps were identified between DEGs (show DEGS1 Proteins) and target genes of ESR1, of which 12 were found to be regulated by miRNA. Several known estrogen response genes and novel genes were obtained in this study and they might provide potential therapeutic targets for osteosarcoma
The negative correlation between high-grade expression HCMV-IE and hormone receptor (show NR4A1 Proteins) expression suggests a role for HCMV in hormone receptor (show NR4A1 Proteins)-negative BC tumors, possibly by forcing BC cells into a more aggressive phenotype.
Gender differences were observed in ERalpha expression in normal livers. Sub-cellular expression of both ER subtypes is altered in hepatitis C virus (HCV) cirrhosis and HCV-related hepatocellular carcinoma livers as compared to normals and correlates with the expression of inflammatory and oncogenic markers.
Report yeast estrogen screen for androgen- and estrogen-receptor mediated activities of 4-hydroxytestosterone, 4-hydroxyandrostenedione and their human metabolites.
Computational analysis of publicly available microarray datasets of non-small cell lung cancer (NSCC) treated with EGFR (show EGFR Proteins) targeted therapy identified ESR1 and ELAV1 (show ELAVL1 Proteins) as the most highly ranked hub genes involved in the NSCLC acquired TKI-resistance.
No association was found between the ERalpha gene polymorphisms and Premature thelarche in girls. However, XbaI polymorphisms may contribute to early breast budding.
significant prognostic roles of ERalpha, ERbeta (show ESR2 Proteins) and aromatase (show CYP19A1 Proteins) were discovered in the in prostate cancer specimens of our large multicenter cohort.
Sp1 (show PSG1 Proteins) induces leptin (show LEP Proteins) expression in cooperation with estradiol action through estrogen receptor alpha
synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
estrogen receptor alpha 1
, estradiol receptor
, estrogen receptor
, nuclear receptor subfamily 3 group A member 1
, estrogen receptor alpha
, estrogen receptor, alpha
, estrogen nuclear receptor alpha
, estrogen receptor alpha 3*,4,5,6,7*/822 isoform
, estrogen receptor alpha E1-E2-1-2
, estrogen receptor alpha E1-N2-E2-1-2
, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
, estrogen receptor alpha delta 4 +49 isoform
, estrogen receptor alpha delta 4*,5,6,7*/654 isoform
, estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
, Er alpha
, estrogen receptor 1 (alpha)
, estrogen receptor alpha variant delta 4
, estrogen receptor protein
, estrogen receptor 1
, nuclear receptor
, Estradiol receptor
, Nuclear receptor subfamily 3 group A member 1
, estrogen alpha receptor