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Rev-erbalpha (show NR1D1 Proteins) regulates Cyp7a1 (show CYP7A1 Proteins) and cholesterol metabolism through its repression of the Lrh-1 (show NR5A2 Proteins) receptor.
Data show that miR (show MLXIP Proteins)-210 inhibits the expression of nuclear receptor subfamily 1, group D, member 2 (NR1D2), particularly in cryptorchidic tissues.
These results demonstrate the importance of the Rev-erbbeta HRM in regulating interactions with heme and NCoR1 and advance our understanding of how signaling through HRMs affects the major cellular processes of circadian rhythm maintenance and metabolism.
heme is involved in regulating the degradation of Rev-erbbeta in a manner consistent with its role in circadian rhythm maintenance
Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 (show MMP9 Proteins) and CCL2 (show CCL2 Proteins) transcription, of astroglial REV-ERBs activation through HDAC3 (show HDAC3 Proteins)-dependent and HDAC3 (show HDAC3 Proteins)-independent mechanisms.
REV-ERBbeta plays a role in supporting cancer cell viability when autophagy is compromised.
REV-ERB-ALPHA (show NR1D1 Proteins) circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.
Cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnPP) are ligands that bind directly to the REV-ERBs. However, instead of mimicking the agonist action of heme, CoPP and ZnPP function as antagonists of REV-ERB function.
Our results suggest that the REV-ERBalpha (show NR1D1 Proteins) rs2071427 polymorphism modulates body fat mass in both adult and young people.
oxidative stress leads to oxidation of cysteine(s), thus releasing heme from Rev-erbbeta and altering its transcriptional activity.
REV-ERBbeta drives mitochondrial biogenesis and the expression of genes involved in fatty acid oxidation. REV-ERBbeta-deficient mice exhibited an altered metabolic phenotype compared to wild-type littermates. REV-ERBbeta plays a role in the control of skeletal muscle metabolism and energy expenditure
Loss of REV-ERB-BETA leads to de-repression of orexinergic genes.
In conclusion, the present study demonstrates that KK-S6 functions as a novel modulator of the amplitude of molecular circadian rhythms by influencing RORE-mediated BMAL1 (show ARNTL Proteins) expression.
Genetic deletion of the Rev-erbalpha (show NR1D1 Proteins) gene or pharmacological inhibition of REV-ERBalpha (show NR1D1 Proteins) activity in the ventral midbrain induced mania-like behavior in association with a central hyperdopaminergic state.
data now unite REV-ERB-alpha and REV-ERB-beta with PER, CRY and other components of the principal feedback loop that drives circadian expression and indicate a more integral mechanism for the coordination of circadian rhythm and metabolism
In mouse livers, Rev-erbbeta mRNA and protein levels oscillate with a diurnal pattern similar to that of Rev-erbalpha, and both Rev-erbs are recruited to a remarkably similar set of binding sites across the genome, enriched near metabolic genes
The results suggest that heme, functioning as a REV-ERB ligand, is an important signaling molecule for induction of adipogenesis. Synthetic small molecule ligands for REV-ERB are effective modulators of adipogenesis.
oscillation of p21WAF1/CIP1 gene transcription is regulated by the antagonistic activities of the orphan nuclear receptors REV-ERBalpha (show NR1D1 Proteins)/beta and RORalpha4/gamma, which are core clock regulators
examined cell-autonomous circadian oscillations using combined gene knockout and RNA interference and demonstrated that REV-ERBalpha (show NR1D1 Proteins) and beta are functionally redundant and are required for rhythmic Bmal1 (show ARNTL Proteins) expression
These data suggest that Rev-erb beta has the potential to activate gene expression, and is a positive regulator of Srebp-1c (show SREBF1 Proteins), a regulator of lipogenesis.
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
V-erbA-related protein 1-related
, nuclear receptor Rev-ErbA beta variant 1
, nuclear receptor Rev-ErbA beta variant 2
, nuclear receptor subfamily 1 group D member 2
, orphan nuclear hormone receptor BD73
, rev-erba-alpha-related receptor
, orphan nuclear receptor HZF-2
, orphan receptor
, Rev-erb beta
, orphan nuclear receptor RVR
, nuclear receptor subfamily 1, group D, member 2
, Nuclear receptor subfamily 1 group D member 2-like protein
, Rev-Erb Beta 1
, nuclear receptor subfamily 1, group D, member 2a