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Human NR5A2 + LRH1 Protein expressed in Wheat germ - ABIN1312989
Khan, Narayanan, Lu, Choo, Du, Wiradharma, Yang, Wan: Delivery of reprogramming factors into fibroblasts for generation of non-genetic induced pluripotent stem cells using a cationic bolaamphiphile as a non-viral vector. in Biomaterials 2013
Results show that LRH-1 is a direct target gene of miR (show MLXIP Proteins)-374b and that decreased miR (show MLXIP Proteins)-374b expression may contribute to the promotion of LRH-1-mediated tumorigenesis of colon cancer.
NR5A2 may be important in the pathophysiology of preterm birth and exploring noncoding regulators of NR5A2 is warranted
Our study suggests that miR (show MLXIP Proteins)-219-5p regulated the proliferation, migration, and invasion of human gastric cancer cells by suppressing LRH-1.
Liver receptor homolog-1 was identified as a direct target gene of miR (show MLXIP Proteins)-136
miR (show MLXIP Proteins)-27b-3p levels were found to be significantly negatively correlated with both NR5A2 and CREB1 (show CREB1 Proteins) levels in breast cancer tissues.
The fusion transcript NR5A2-KLHL29FT was identified in normal and cancerous colonic epithelia. It is due to an uncharacterized polymorphic germline insertion of the NR5A2 sequence from chromosome 1 into the KLHL29 locus at chromosome 2, rather than a chromosomal rearrangement. NR5A2-KLH29FT expression levels were significantly lower in colon cancers than in matched normal colonic epithelia.
Additionally, the authors solved the structure of the human LRH-1 DNA-binding domain bound to a DR0 motif located within the Oct4 (show POU5F1 Proteins) promoter.
miR (show MLXIP Proteins)-376c inhibits non-small-cell lung cancer cell growth and invasion by targeting LRH-1
The first crystal structure of the LRH-1-PGC1alpha complex , which depicts hydrophobic contacts is identified and described.
The dramatic repositioning is influenced by a differential ability to establish stable face-to-face pi-pi-stacking with the LRH-1 residue His-390, as well as by a novel polar interaction mediated by the RJW100 hydroxyl group. The differing binding modes result in distinct mechanisms of action for the two agonists.
results suggest that Sod2 (show SOD2 Proteins) is a target gene of LRH-1, and that LRH-1 agonists can mediate a reduction in ROS (show ROS1 Proteins) production and oxidative stress driven by an excess of fatty acids, as exhibited in nonalcoholic fatty liver disease
These findings suggest that compromised SUMOylation of LRH-1 promotes the development of nonalcoholic fatty liver disease under lipogenic conditions through regulation of OSBPL3 (show OSBPL3 Proteins).
these data show for the first time LRH-1 expression in T cells, its role in FASLG (show FASL Proteins) transcription and the potential of pharmacological inhibition of LRH-1 in the treatment of FasL (show FASL Proteins)-mediated immunopathologies
highlight the importance of LRH-1 in coordinating glutamine-induced metabolism and signaling to promote hepatocellular carcinogenesis.
Mice carrying a mutation on lysine 289 of LRH-1 (Lrh1 K289R mice) display reduced LRH-1 SUMOylation and increased expression of genes regulating cholesterol transport.
Results identify LRH-1 as a critical component of the anti-inflammatory and fungicidal response of alternatively activated macrophages that acts upstream from the IL-13 (show IL13 Proteins)-induced 15-HETE/PPARgamma (show PPARG Proteins) axis.
The authors conclude that LRH-1 initiates a novel pathway of endoplasmic reticulum stress resolution that is independent of the unfolded protein response, yet equivalently required.
study demonstrates for the first time that LRH-1 has a CRT (show SLC6A8 Proteins)-dependent NES (show NES Proteins) which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation.
Heterozygous gene deletion of LRH-1 causes body weight gains without any apparent worsening of glucose and lipid metabolism.
NR5A2 has a role in controlling aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis
GATA4 (show GATA4 Proteins) and GATA6 (show GATA6 Proteins) mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 (show GATA6 Proteins) showed a marked decrease at the regressed luteal stage, like NR5A1 (show NR5A1 Proteins), NR5A2, and the other steroidogenic markers.
NR5A2 (LRH-1, SF2 (show SRSF1 Proteins)) mRNA is upregulated in granulosa cells of dominant and hCG (show CGA Proteins)-induced ovulatory ovarian follicles.
Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.
nuclear receptor subfamily 5, group A, member 2
, Ftz-F1-related orphan receptor A
, FTZ-F1-related nuclear orphan receptor
, Ftz-F1-related orphan receptor
, liver receptor-like protein 1
, CYP7A promoter-binding factor
, alpha-1-fetoprotein transcription factor
, b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus
, fetoprotein-alpha 1 (AFP) transcription factor
, hepatocytic transcription factor
, liver nuclear receptor homolog-1 variant 2
, liver receptor homolog 1
, liver receptor homolog-1
, nuclear receptor NR5A2
, nuclear receptor subfamily 5 group A member 2
, Ftz-F1-related orphan receptor B
, fetoprotein transcription factor
, FTZ-F1 beta
, FTZ-F1 beta2 protein