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PDX1, Neurogenin-3 (show NEUROG3 Proteins), and MAFA (show KLRG1 Proteins) are critical transcription regulators for beta cell development and regeneration. (Review)
study provides a novel culture protocol for generating pancreas-committed cells from hAECs and reveals an interplay between Pdx1 and activin A (show INHBA Proteins)/nicotinamide signaling in early pancreatic fate determination.
Data indicate the secretory granule membrane glycoprotein 2 as a marker for PDX1+/NKX6-1+ pancreatic progenitors (PPs).
expression of regulatory master genes of embryonic development in pancreatic cancer cells on the intracellular concentration of the master regulator PDX1
Efficiency of differentiation of Induced pluripotent stem cells to insulin (show INS Proteins) producing cells can be increased by concurrent expression of PDX1 and NKX6.1 (show NKX6-1 Proteins) during progenitor cells maturation.
Mutation in PDX1 gene is associated with Maturity Onset Diabetes of the Young.
Results found that Pdx-1 overexpression exerts its effects on islet cell replication via a noncell-autonomous mechanism involving induction of a secreted soluble factor or factors. Also, Inhbb (show INHBB Proteins) is identified as one factor mediating the proliferative effect of Pdx-1.
Our findings indicate that MET induces the differentiation of Pdx1-expressing cells within the definitive endoderm in a time-dependent manner, and suggest useful application for regenerative medicine.
Pdx1 and MafA (show KLRG1 Proteins) play crucial roles in the pancreas and maintain mature beta-cell function. Our results showed that the expression of Pdx1 and MafA (show KLRG1 Proteins) were significantly upregulated after a sleeve gastrectomy for morbid obesity.
Data show that the expression patterns of sex determining region Y-box 2 (SOX2 (show SOX2 Proteins)) and pancreatic and duodenal homeobox 1 (Pdx1)) highly correlated with prognosis of pancreatic neuroendocrine tumors (p-NETs).
Report pancreatic expression of Pdx-1 in pancreas.
the present study demonstrated that Pdx1+/-/Alzheimer mice exhibit enhanced cognitive decline, amyloid-beta plaque deposition, tau hyperphosphorylation, the loss of synaptic spine protein, and activation of microglia and astrocytes.
This study showed that altered Pdx1 mRNA and protein levels in weaned male mutant beta-cells were tightly linked with hyperglycemia, decreased beta-cell proliferation, reduced beta-cell area, and altered expression of Pdx1-bound genes that are important in beta-cell replication, endoplasmic reticulum function, and mitochondrial activity.
These results suggest that Oc1 (show ONECUT1 Proteins) and Pdx1 cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells.
Data suggest that hepatocytes can be reprogrammed into insulin (show INS Proteins)-producing cells in vivo by transfection of neurogenin-3 (show NEUROG3 Proteins), Pdx1, and MafA (show MAFA Proteins) genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA (show MAFA Proteins) = v-maf (show MAF Proteins) musculoaponeurotic fibrosarcoma oncogene (show RAB1A Proteins) family, protein A (show GPR153 Proteins))
PDX1 and ISL1 (show ISL1 Proteins) regulation of insulin (show INS Proteins) gene expression in pancreatic beta cells, was investigated.
Creating the Pdx1(DeltaAREAII) state after cells entered an insulin (show INS Proteins)-expressing stage led to immature and dysfunctional islet beta cells carrying abnormal chromatin marking in vital beta-cell-associated genes. Therefore, trans-regulatory integration through Area II mediates a surprisingly extensive range of progenitor and beta-cell-specific Pdx1 functions.
The use of a GFP reporter knocked into the endogenous Pdx1 promoter allowed us to monitor pancreatic induction based on the expression of Pdx1, a pancreatic master transcription factor, and to isolate a pure Pdx1-GFP(+) population for downstream applications.
Upon neoplastic transformation, the role of PDX1 changes from tumor-suppressive to oncogenic
PDX1 role in beta-cell function and diabetes
At the molecular level, administration of liraglutide induced the expression of PDX-1, MafA (show MAFA Proteins), p-JAK2 (show JAK2 Proteins) and p-Stat3 (show STAT3 Proteins) in high-fat diet-induced diabetes model to relatively normal levels.
Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment
A pdx1-dependent progenitor population essential for the formation of duct-associated, second wave endocrine cells, is demonstrated.
Pdx-1 plays multiple roles in maintaining the phenotype of the islet during embryogenesis.
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
, glucose-sensitive factor
, insulin promoter factor 1, homeodomain transcription factor
, insulin upstream factor 1
, islet/duodenum homeobox-1
, pancreas/duodenum homeobox protein 1
, pancreatic-duodenal homeobox factor 1
, somatostatin transcription factor 1
, somatostatin-transactivating factor 1
, homeodomain protein PDX-1
, pancreatic and duodenum homeobox 1
, pancreatic duodenal homeobox gene 1
, pancreatic and duodenal homeobox 1
, islet/duodenum homeobox 1
, pancreatic and duodenal homeobox gene 1
, Insulin promoter factor 1
, insulin promotor factor 1
, somatostatin transactivating factor 1
, homeodomain protein PDX1
, Homeobox protein 8
, XlHbox 8 protein
, LOW QUALITY PROTEIN: pancreas/duodenum homeobox protein 1
, Homeodomain protein PDX1