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Cow (Bovine) Monoclonal PPARA Primary Antibody for ChIP, FACS - ABIN152696
Sumanasekera, Tien, Turpey, Vanden Heuvel, Perdew: Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. in The Journal of biological chemistry 2003
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Cow (Bovine) Polyclonal PPARA Primary Antibody for ChIP, ELISA - ABIN153509
Selwyn, Cheng, Klaassen, Cui: Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics. in Drug metabolism and disposition: the biological fate of chemicals 2016
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Human Monoclonal PPARA Primary Antibody for WB - ABIN1944858
Mukherjee, Jow, Noonan, McDonnell: Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. in The Journal of steroid biochemistry and molecular biology 1995
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Human Polyclonal PPARA Primary Antibody for ICC, IHC (fro) - ABIN3044397
Zhou, Zhang, Xu, Wang: Curcumin ameliorates renal fibrosis by inhibiting local fibroblast proliferation and extracellular matrix deposition. in Journal of pharmacological sciences 2015
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Mouse (Murine) Polyclonal PPARA Primary Antibody for IF, IP - ABIN285918
Suardíaz, Estivill-Torrús, Goicoechea, Bilbao, Rodríguez de Fonseca: Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain. in Pain 2007
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Mouse (Murine) Polyclonal PPARA Primary Antibody for IHC, ELISA - ABIN1043876
Plutzky: Medicine. PPARs as therapeutic targets: reverse cardiology? in Science (New York, N.Y.) 2003
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Human Polyclonal PPARA Primary Antibody for IF (p), IHC (p) - ABIN753163
Mölzer, Wallner, Kern, Tosevska, Schwarz, Zadnikar, Doberer, Marculescu, Wagner: Features of an altered AMPK metabolic pathway in Gilbert's Syndrome, and its role in metabolic health. in Scientific reports 2016
Mouse (Murine) Monoclonal PPARA Primary Antibody for GS, IP - ABIN284693
Longuet, Sinclair, Maida, Baggio, Maziarz, Charron, Drucker: The glucagon receptor is required for the adaptive metabolic response to fasting. in Cell metabolism 2008
Cow (Bovine) Polyclonal PPARA Primary Antibody for ELISA, ICC - ABIN4346988
Baker, Ball, Rakha, Nolan, Caldas, Ellis, Green: Lack of expression of the proteins GMPR2 and PPARα are associated with the basal phenotype and patient outcome in breast cancer. in Breast cancer research and treatment 2012
High concentrations of DINCH urinary metabolites activate human PPAR-alpha.
PPARalpha is overexpressed in primary glioblastoma
these results suggest that the E2F1 (show E2F1 Antibodies)/miR19a/PPARalpha feedback loop is critical for glioma progression
Data conclude that the ER-stress mediated reduction in apoA-I (show APOA1 Antibodies) transcription could be partly mediated via the inhibition of PPARalpha mRNA expression and activity. In addition, BET inhibition increased apoA-I (show APOA1 Antibodies) transcription, even if PPARalpha production and activity were decreased. Both BET inhibition and PPARalpha activation ameliorate the apoA-I (show APOA1 Antibodies) lowering effect of ER-stress and are therefore interesting targets to elev...
Results demonstrated that PPARa directly inhibited Glut1 (show SLC2A1 Antibodies) mRNA expression resulting in influx of glucose in cancer cells.
PPARalpha and LXRalpha (show NR1H3 Antibodies) may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Our results support an important association between rs1800206 minor allele of PPAR alpha and diabetic retinopathy, and the interaction analysis also shown a combined effect of Leu162 allele-abdominal obesity interaction on diabetic retinopathy.
Taken together, our data suggest that eupatilin inhibits TNFalpha (show TNF Antibodies)-induced MMP-2 (show MMP2 Antibodies)/-9 expression by suppressing NF-kappaB (show NFKB1 Antibodies) and MAPKAP-1 (show MAPKAP1 Antibodies) pathways via PPARalpha. Our findings suggest the usefulness of eupatilin for preventing skin aging.
Hepatic PARP1 (show PARP1 Antibodies) activation inhibits FAO pathway upregulation through poly(ADP-ribosyl)ation of PPARalpha, worsening hepatic steatosis and inflammatory responses associated with overnutrition.
Aleglitazar protects cardiomyocytes against hyperglycaemia-induced apoptosis by combined activation of both peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma (show PPARG Antibodies).
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 (show SLC22A5 Antibodies) expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma (show PPARG Antibodies)) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 (show PTGS2 Antibodies) levels in bovine endometrial stromal cells.
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (show DGAT1 Antibodies) (SSC4p15), PPARA (SSC5p15), ADIPOR1 (show ADIPOR1 Antibodies) (SSC10p13) and CREB (show CREB1 Antibodies) (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM (show MUC19 Antibodies)) may contribute to the susceptibility of BSM (show MUC19 Antibodies) to lipotoxicity in the metabolic syndrome.
These findings indicate that PPARalpha promotes osteogenic differentiation via the Sirt1 (show SIRT1 Antibodies)-dependent signaling pathway.
CD36 (show CD36 Antibodies) is essential for endurance improvement, changes in whole-body metabolism, and efficient peroxisome-proliferator activated receptors (PPAR)-related transcriptional responses in the muscle with exercise training.
In mice, the oral administration of linalool for 3 weeks reduced plasma TG concentrations in Western-diet-fed C57BL/6J mice (31%, P < 0.05) and human apo (show C9orf3 Antibodies) E2 mice (50%, P < 0.05) and regulated hepatic PPARalpha target genes.
a novel PPARalpha-dependent gene
fenofibrate upregulated VLDLR (show VLDLR Antibodies) transcriptional activity through PPAR response element binding to the VLDLR (show VLDLR Antibodies) promoter.
PPARalpha activation contributes to liver protection and decreases hepatocyte apoptosis in acute liver failure, particularly through regulating endoplasmic reticulum stress.
These results suggest that HCVcp-induced age-dependent PPARalpha activation increases synthesis of sulfatides and the resulting sulfatide accumulation affects HCV-related liver cancer.
These findings suggested that PPARalpha activation in adipose tissue contributes to the improvement of glucose metabolism disorders via the enhancement of BCAA (show ARID4B Antibodies) and FFA metabolism.
TGF-beta (show TGFB1 Antibodies) and PPARalpha signaling pathways are involved in radiation-induced heart fibrosis, metabolic dysregulation, and impaired heart contractility, a pathophysiological condition that is often observed in patients that received high radiation doses in thorax.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor alpha
, ppar alpha
, xPPAR alpha
, peroxisome proliferator-activated receptor-alpha