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Cow (Bovine) Monoclonal PPARA Primary Antibody for ChIP, FACS - ABIN152696
Sumanasekera, Tien, Turpey, Vanden Heuvel, Perdew: Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. in The Journal of biological chemistry 2003
Show all 10 Pubmed References
Cow (Bovine) Polyclonal PPARA Primary Antibody for ChIP, ELISA - ABIN153509
Selwyn, Cheng, Klaassen, Cui: Regulation of Hepatic Drug-Metabolizing Enzymes in Germ-Free Mice by Conventionalization and Probiotics. in Drug metabolism and disposition: the biological fate of chemicals 2016
Show all 10 Pubmed References
Human Polyclonal PPARA Primary Antibody for ICC, IHC (fro) - ABIN3044397
Zhou, Zhang, Xu, Wang: Curcumin ameliorates renal fibrosis by inhibiting local fibroblast proliferation and extracellular matrix deposition. in Journal of pharmacological sciences 2015
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Polyclonal PPARA Primary Antibody for ELISA, WB - ABIN539548
Lazar: Progress in cardiovascular biology: PPAR for the course. in Nature medicine 2001
Show all 4 Pubmed References
Mouse (Murine) Polyclonal PPARA Primary Antibody for IF, IP - ABIN285918
Suardíaz, Estivill-Torrús, Goicoechea, Bilbao, Rodríguez de Fonseca: Analgesic properties of oleoylethanolamide (OEA) in visceral and inflammatory pain. in Pain 2007
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Mouse (Murine) Polyclonal PPARA Primary Antibody for IHC, ELISA - ABIN105798
Mukherjee, Jow, Noonan, McDonnell: Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. in The Journal of steroid biochemistry and molecular biology 1995
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Cow (Bovine) Polyclonal PPARA Primary Antibody for WB - ABIN223278
Hennessy, Sheedy, Santamaria, Barbacid, ONeill: Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6. in The Journal of biological chemistry 2011
Mouse (Murine) Monoclonal PPARA Primary Antibody for GS, IP - ABIN284693
Longuet, Sinclair, Maida, Baggio, Maziarz, Charron, Drucker: The glucagon receptor is required for the adaptive metabolic response to fasting. in Cell metabolism 2008
Cow (Bovine) Polyclonal PPARA Primary Antibody for WB - ABIN549469
Miranda, Escoté, Ceperuelo-Mallafré, Megía, Caubet, Näf, Gómez, González-Clemente, Vicente, Vendrell: Relation between human LPIN1, hypoxia and endoplasmic reticulum stress genes in subcutaneous and visceral adipose tissue. in International journal of obesity (2005) 2010
Human Polyclonal PPARA Primary Antibody for WB - ABIN3017411
Lv, Wang, Liu, Liang, Feng, Zhang, Xu: Protective effect of Fenofibrate in renal ischemia reperfusion injury: Involved in suppressing kinase 2 (JAK2)/transcription 3 (STAT3)/p53 signaling activation. in Pathologie-biologie 2016
Mechanically, MEG8 was found to promote the PPARalpha protein via sponging miR-181a-5p
Dual activation of peroxisome proliferator-activated receptors alpha and delta improves the efficacy of adoptive cell therapy by reprogramming T-cell metabolism and cytokine expression
The expression of downstream processes corroborates active PPARalpha signaling in LSECs. We uncover transcriptional evidence in LSECs for a feedback mechanism between PPARalpha and farnesoid X-activated receptor (FXR) that maintains bile acid homeostasis; previously, this feedback was known occur only in HepG2 cells.
findings suggest that Naoxintong could retard atherosclerosis by inhibiting foam cell formation through reducing ox-LDL uptake and enhancing cholesterol efflux and above beneficial effects are partly mediated through PPARalpha pathway.
These findings indicate a previously unknown role for PPARA and NR1H4 in regulating the autophagy-ciliogenesis axis.
Loss of PPARalpha from the intestine promotes colon carcinogenesis by increasing DNMT1/PRMT6-mediated DNA methylation.
The downregulation of miR-181a expression can be a therapeutic strategy for non-alcoholic fatty liver disease by modulating its target PPARalpha.
These results suggested that ZNF300 plays an important role in hepatic lipid metabolism via PPARalpha promoting fatty acid oxidation and this effect might be blocked by DNMT3a-mediated methylation of ZNF300.
PPAR polymorphisms may predict intellectual outcome changes in children treated for medulloblastoma
This study concludes that a lower Ser482 allele frequency of the PPARGC1A gene and possibly a higher GG genotype frequency of the PPARa gene are associated with the aerobic activities and endurance performance. In addition, it reinforces the theory that improved PPARGC1A and PPARa gene expression and/or protein activity may be beneficial to the endurance activities.
beta-Conglycinin and fish oil are effective at preventing alcoholic fatty liver because beta-conglycinin decreases the function of SREBP-1c and PPARgamma2, and fish oil decreases the function of SREBP-1c and increases that of PPARalpha
High PPARA expression promotes pancreatic cancer and clofibrate-mediated PPARA activation sensitizes pancreatic cancer cells to radiation through the Wnt/beta-catenin pathway.
Taken together, PPARalpha-mediated metabolic induction and proliferation of peroxisomes via a PPRE-dependent mechanism could compensate PPARgamma-deficiency in club cells.
There is an up-expression of PPARalpha target genes in the PBMCs of NAFLD patients
This review focus is on the function and mechanisms of PPAR alpha in the cardiovascular system under various pathological conditions, including vascular and heart injury, blood pressure regulation, and lipid disorder-related cardiovascular injury, as well as its polymorphisms and pharmacogenetic associations with cardiovascular diseases. [review]
PIK3R3 regulates the expression of PPAR-alpha in hepatocytes.The novel PIK3R3-HNF4alpha-PPAR-alpha signaling axis plays a significant role in hepatic lipid metabolism.
Ubiquitination modification through the coordinated action of PAQR3 with HUWE1 plays a crucial role in regulating the activity of hepatic PPARalpha in response to starvation.
Circulated eosinophilic expression of PPARalpha protein is reduced in metabolic syndrome.
TNFalpha differently regulated the levels of PPARalpha, LXRalpha, and LXRbeta binding to the apoA-I gene promoter in THP-1 cells. Obtained results suggest a novel tissue-specific mechanism of the TNFalpha-mediated regulation of apoA-I gene in monocytes and macrophages and show that endogenous ApoA-I might be positively regulated in macrophage during inflammation.
MAR1 ameliorates LPS-induced atherosclerotic reactions via PPARalpha-mediated suppression of inflammation and ER stress.
This study investigated FA composition in yaks and cattle, in order to ascertain whether a correlation between PPARalpha signal pathway genes as candidate genes and meat FA composition in yaks and cattle exists.
OCTN2 expression and carnitine transport in cattle, as in rodents, are regulated by PPARalpha.
In conclusion, H8H8 haplotype combination of the PPARalpha may be advantageous for heat resistance traits in Chinese Holstein cattle.
Data suggest that PPARalpha (but not PPARgamma) is involved in vasorelaxation of ophthalmic artery in response to endocannabinoids (i.e., anandamide, palmitoylethanolamide); endothelium removal slightly decreases the response to endocannabinoids.
Data from gene profiling experiments in bovine cell line support hypothesis that saturated long-chain fatty acids modulate ruminant lipid metabolism and expression of inflammation mediators with major effects induced via activation of PPARalpha.
Dietary trans fatty acids may affect liver lipid metabolism in post-partum dairy cows through alterations in PPARalpha gene expression.
Oxidized fataprevent an alcohol-induced triacylglycerol accumulation in rats possibly by upregulation of hepatic PPARalpha-responsive genes, whwereas conjugated linoleic acid does not.
The results are consistent with the hypothesis that arachidonic acid acts via PPARalpha to increase PTGS2 levels in bovine endometrial stromal cells.
Our results provide novel insights into regulation of PPAR expression in ovarian follicles. We observed that FSH increased mRNA and protein expression of all PPARs isoforms, while LH only increased PPAR alpha and gamma. Steroids like progesterone and estradiol increased expression of PPAR alpha and gamma without affecting the beta isoform, while testosterone had no effect on all PPARs expression.
The c.*636A>G SNP in the PPARA gene can be considered in Polish Landrace breed as a useful genetic marker for adipose tissue accumulation.
The results indicate that the endometrial expression of PPARalpha genes fluctuates during the estrous cycle and pregnancy.
PPARalpha is likely to play a central role in adaptation to fasting in pig liver
Despite expression of PPAR-alpha in porcine myocardium and effects of fenofibrate on systemic metabolism, treatment with this PPAR-alpha activator does not alter myocardial metabolic or contractile responses to I/R in pigs.
FISH localization of 4 BAC clones harbouring potential candidate genes for fatness traits: DGAT1 (SSC4p15), PPARA (SSC5p15), ADIPOR1 (SSC10p13) and CREB (SSC15q24)
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
Peroxisome proliferation could lead to increased susceptibility to bacterial pathogens in tobacco by altering the redox balance of the plant and the expression pattern of key defense signaling pathway genes.
Our study demonstrated that hippocampal PPARalpha participated in depression, as a novel and feasible antidepressant target.
These results indicate that PPARalpha promotes liver regeneration after partial hepatectomy, at least partially via regulating the cell cycle and lipid metabolism.
results provide the first direct evidence that GLP-1 protects cardiac function by inhibiting the ROCK/PPARalpha pathway, thereby ameliorating lipotoxicity in diabetic cardiomyopathy
These findings indicate a previously unknown role for PPARA and NR1H4 in regulating the autophagy-ciliogenesis.
Compared with kidneys of aged littermate controls, kidneys of aged PPARalpha(-/-) mice showed exaggerated lipid accumulation, with decreased activity of the fatty acid oxidation pathway and a severe renal fibrosis phenotype.
BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARgamma and GLUT4 upregulation
Data provide evidence that PPARalpha is a master regulator of intracellular lipid metabolism.
protection against cholestasis by basal PPARalpha involves regulation of bile acid metabolism and inhibition of NF-kappaB/STAT3 signaling.
a central role of PPARalpha in cardiac response to ionizing radiation
Autophagy and mitochondrial metabolism are transcriptionally controlled by the class 3 PI3K which controls the nuclear receptor PPARalpha.
Study in GPS2 knockout mice reveals that GPS2 in hepatocytes functionally cooperates with NCOR but not with SMRT to repress PPAR-alpha. These data collectively suggest that GPS2 promotes the progression of fatty liver disease as an epigenome modifier and PPAR-alpha-selective corepressor in hepatocytes.
these data indicate that H19 inhibition protects the heart against myocardial I/R injury, which may be partly attributed to regulation of the miR-675/PPARalpha axis.
MiR-30c/PGC-1beta protects against diabetic cardiomyopathy via PPARalpha signaling pathway.
Using PPARalpha knockout (KO) mice a significant difference between wild-type (WT) and KO mice was seen in the passive avoidance test, demonstrating that KO mice showed enhanced fear leaning. In the amygdala of KO mice, the levels of dopamine and its metabolites were increased, and the mRNA expression of dopamine degrading enzyme was decreased.
These results suggest that PPARalpha is a trans-acting factor that enhances Insig2a gene expression, thereby suppressing SREBP-1c processing during fasting.
oleoylethanolamide injection acutely decreased energy expenditure in controls, this effect was not observed in mice devoid of PPARalpha in the intestine
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers\; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
, nuclear receptor subfamily 1 group C member 1
, peroxisome proliferative activated receptor, alpha
, peroxisome proliferator-activated nuclear receptor alpha variant 3
, PPAR alpha
, peroxisome proliferator activated receptor alpha
, peroxisome proliferator-activated receptor alpha
, ppar alpha
, xPPAR alpha
, peroxisome proliferator-activated receptor-alpha