anti-Rabbit Progesterone Receptor antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended Progesterone Receptor Antibody (supplied by: Log in to see )

Antigen
Progesterone Receptor (PGR) Antibodies
  • NR3C3
  • PR
  • 9930019P03Rik
  • BB114106
  • ENSMUSG00000074510
  • PR-A
  • PR-B
  • XPR-1
  • pgr
  • xpr-2
  • LOC443444
  • PGR
  • pg
  • pr
  • gb:dq017620
  • progesterone receptor
  • progesterone receptor L homeolog
  • PGR
  • Pgr
  • pgr.L
  • pgr
Epitope
AA 922-933, C-Term
54
45
41
27
23
21
19
17
17
15
15
15
12
11
10
9
9
8
7
7
7
6
5
5
5
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Human, Rabbit
700
114
108
37
25
21
19
17
15
15
12
11
6
5
2
1
1
1
1
1
Host
Mouse
389
339
3
1
Clonality
Monoclonal
Conjugate
This Progesterone Receptor antibody is un-conjugated
25
21
17
14
14
12
8
8
6
6
6
6
6
6
6
5
5
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
550
220
187
184
130
71
67
55
54
36
28
19
9
3
2
2
1
1
1
1
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Catalog No. ABIN781660
$ 511.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4 ABIN385222 IF IHC IHC (p) IP WB Mouse IgG1, kappa Log in to see hPRa 2 0
1 ABIN209187 ICC IHC IHC (fro) IHC (p) IP WB Mouse IgG2a Log in to see 0
-3.527007 ABIN266931 ICC IHC (fro) IF IHC (p) IP IHC WB Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347461 ICC IF IHC (fro) IHC (p) WB DyLight 488 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347465 ICC IF IHC (fro) IHC (p) WB DyLight 680 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347467 ICC IF IHC (fro) IHC (p) WB Alexa Fluor 405 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347469 ICC IF IHC (fro) IHC (p) WB Alexa Fluor 488 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347471 ICC IF IHC (fro) IHC (p) WB Alexa Fluor 647 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347473 ICC IF IHC (fro) IHC (p) WB Alexa Fluor 700 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347452 ICC IF IHC (fro) IHC (p) WB DyLight 405 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347459 ICC IF IHC (fro) IHC (p) WB DyLight 755 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN4347450 ICC IF IHC (fro) IHC (p) WB DyLight 350 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN5946887 ICC IF IHC IHC (fro) IHC (p) Janelia Fluor® 549 Mouse IgG2a B form Log in to see Alpha PR6 0
-11.02447 ABIN5946888 ICC IF IHC IHC (fro) IHC (p) Janelia Fluor® 646 Mouse IgG2a B form Log in to see Alpha PR6 0

General

Antigen Progesterone Receptor (PGR) Antibodies
Epitope AA 922-933, C-Term
(54), (45), (41), (27), (23), (21), (19), (17), (17), (15), (15), (15), (12), (11), (10), (9), (9), (8), (7), (7), (7), (6), (5), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Chicken, Human, Rabbit
(700), (114), (108), (37), (25), (21), (19), (17), (15), (15), (12), (11), (6), (5), (2), (1), (1), (1), (1), (1)
Host Mouse
(389), (339), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Progesterone Receptor antibody is un-conjugated
(25), (21), (17), (14), (14), (12), (8), (8), (6), (6), (6), (6), (6), (6), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(550), (220), (187), (184), (130), (71), (67), (55), (54), (36), (28), (19), (9), (3), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-Progesterone Receptor Antibody

Target Details Progesterone Receptor Application Details Handling References for anti-Progesterone Receptor antibody (ABIN781660) Images
Specificity This antibody PR-6A recognizes the Human Progesterone Receptor in the C-terminal ligand-binding domain. Therefore, it recognizes isoforms A and B. Antigen Distribution: Nuclear hormone receptor, widely expressed.
Cross-Reactivity (Details) Species reactivity (expected):Chicken and Rabbit.
Species reactivity (tested):Human, Pig.
Purification Affinity Chromatography
Immunogen Peptide A922-K933. Epitope: C-terminal region.
Clone PR-6A
Isotype IgG2a
Plasmids, Primers & others

Target Details Progesterone Receptor

Product Details anti-Progesterone Receptor Antibody Application Details Handling References for anti-Progesterone Receptor antibody (ABIN781660) Images back to top
Antigen
Alternative Name Progesterone Receptor (PGR Antibody Abstract)
Background The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. Expressed by a single gene (chromosome 11q22), it has two main forms, A and B, that differ in their molecular weight. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PR determination provides supplementary information to ER, in predicting response to endocrine therapy as well as estimating survival. PR has proved superior to ER as a prognostic indicator in some studies. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.Synonyms: NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3, PGR, PR
Gene ID 5241
NCBI Accession NP_000917
UniProt P06401
Pathways Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration

Application Details

Product Details anti-Progesterone Receptor Antibody Target Details Progesterone Receptor Handling References for anti-Progesterone Receptor antibody (ABIN781660) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Progesterone Receptor Antibody Target Details Progesterone Receptor Application Details References for anti-Progesterone Receptor antibody (ABIN781660) Images back to top
Reconstitution Restore by adding 0.5 mL distilled water
Concentration 0.2 mg/mL
Buffer Stock solution contains PBS, pH 7.2 with 5 mg/mL BSA as stabilizer and 0.01 % Kathon as a preservative.
Preservative Kathon CG
Precaution of Use This product contains Kathon CG a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-Progesterone Receptor antibody (ABIN781660)

Product Details anti-Progesterone Receptor Antibody Target Details Progesterone Receptor Application Details Handling Images back to top
Background publications

Lee, Dai, Hansen, Saner, Price: "Modulation of ATP-induced calcium signaling by progesterone in T47D-Y breast cancer cells." in: Molecular and cellular endocrinology, Vol. 319, Issue 1-2, pp. 109-15, 2010

Tetel, Siegal, Murphy: "Cells in behaviourally relevant brain regions coexpress nuclear receptor coactivators and ovarian steroid receptors." in: Journal of neuroendocrinology, Vol. 19, Issue 4, pp. 262-71, 2007

Price, Hansen, Oliver: "Immunofluorescent localization of a novel progesterone receptor(s) in a T47D-Y breast cancer cell line lacking genomic progesterone receptor expression." in: Journal of the Society for Gynecologic Investigation, Vol. 12, Issue 8, pp. 610-6, 2005

Bennett, Gréco, Blasberg, Blaustein: "Response to male odours in progestin receptor- and oestrogen receptor-containing cells in female rat brain." in: Journal of neuroendocrinology, Vol. 14, Issue 6, pp. 442-9, 2002

Frye: "The role of neurosteroids and non-genomic effects of progestins and androgens in mediating sexual receptivity of rodents." in: Brain research. Brain research reviews, Vol. 37, Issue 1-3, pp. 201-22, 2001

Images

Product Details anti-Progesterone Receptor Antibody Target Details Progesterone Receptor Application Details Handling References for anti-Progesterone Receptor antibody (ABIN781660) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Progesterone Receptor (PGR) (AA 922-933), (C-Term) antibody (ABIN781660) anti-Progesterone Receptor (PGR) (AA 922-933), (C-Term) antibody
Immunohistochemistry (IHC) image for anti-Progesterone Receptor (PGR) (AA 922-933), (C-Term) antibody (ABIN781660) anti-Progesterone Receptor (PGR) (AA 922-933), (C-Term) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-Progesterone Receptor (PGR) (AA 922-933), (C-Term) antibody (ABIN781660) anti-Progesterone Receptor (PGR) (AA 922-933), (C-Term) antibody (Image 3)