anti-Guinea Pig Klotho beta antibody for Immunohistochemistry

Recommended Klotho beta Antibody (supplied by: Log in to see )

Antigen
Klotho beta (KLB) Antibodies
  • KLB
  • BKL
  • AV071179
  • betaKlotho
  • Klb-ps1
  • RGD1308227
  • klotho beta
  • KLB
  • Klb
Epitope
Middle Region
5
4
2
2
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
22
12
3
1
Host
Rabbit
29
2
Clonality
Polyclonal
Conjugate
Un-conjugated
6
3
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
23
13
8
8
5
4
2
2
1
Options
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Available images

Catalog No. ABIN2785343
$ 319.00
Plus shipping costs $45.00

General

Antigen Klotho beta (KLB) Antibodies
Epitope Middle Region
(5), (4), (2), (2), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
(22), (12), (3), (1)
Host Rabbit
(29), (2)
Clonality
Polyclonal
Conjugate Un-conjugated
(6), (3), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(23), (13), (8), (8), (5), (4), (2), (2), (1)
Pubmed 1 reference available
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Product details

Target Details Application Details Handling References Images
Blocking Peptide Blocking peptide for this product available: ABIN978992
Sequence DAYTIRRGLF YVDFNSKQKE RKPKSSAHYY KQIIRENGFS LKESTPDVQG
Predicted Reactivity Cow: 100%, Dog: 93%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 86%, Rat: 100%
Characteristics This is a rabbit polyclonal antibody against KLB. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human KLB

Target Details

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Antigen
Alternative Name KLB (KLB Antibody Abstract)
Background KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
Alias Symbols: BKL, MGC142213
Protein Interaction Partner: FGF21,
Protein Size: 1044
Molecular Weight 120 kDa
Gene ID 152831
NCBI Accession NM_175737, NP_783864
UniProt Q86Z14
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Growth Factor Binding

Application Details

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Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1044 AA

Restrictions For Research Use only

Handling

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Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References

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Background publications

Lu, Katsaros, Wiley, de la Longrais, Puopolo, Yu: "Klotho expression in epithelial ovarian cancer and its association with insulin-like growth factors and disease progression." in: Cancer investigation, Vol. 26, Issue 2, pp. 185-92, 2008

Images

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Supplier Images
Immunohistochemistry (IHC) image for anti-Klotho beta (KLB) (Middle Region) antibody (ABIN2785343) anti-Klotho beta (KLB) (Middle Region) antibody