Orthodenticle Homeobox 2 Products
(Orthodenticle Homeobox 2 (OTX2))
Categories
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012].
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Featured Orthodenticle Homeobox 2 Categories
Orthodenticle Homeobox 2 Antibodies
High quality antibodies with extensive validation data.
Orthodenticle Homeobox 2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Orthodenticle Homeobox 2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Orthodenticle Homeobox 2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (1)
- (6)
Cat. No.
ABIN969332
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
IHC, IF
Validations
- (4)
Cat. No.
ABIN7074952
Quantity
100 μL
Datasheet
Datasheet
Recommended Orthodenticle Homeobox 2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969088
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1137430
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1137429
Quantity
96 tests
Datasheet
Datasheet
Recommended Orthodenticle Homeobox 2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124276
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3085429
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3121044
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our Orthodenticle Homeobox 2 products
: "Stem cells from human exfoliated deciduous tooth exhibit stromal-derived inducing activity and lead to generation of neural crest cells from human embryonic stem cells." in: Cell journal, Vol. 17, Issue 1, pp. 37-48, (2015) (PubMed).: "Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma." in: PLoS ONE, Vol. 10, Issue 9, pp. e0138416, (2015) (PubMed).
: "Endogenous regeneration of damaged retinal pigment epithelium following low dose sodium iodate administration: an insight into the role of glial cells in retinal repair." in: Experimental eye research, Vol. 112, pp. 68-78, (2013) (PubMed).
: "OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas." in: Cancer research, Vol. 70, Issue 1, pp. 181-91, (2010) (PubMed).
: "SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 26933-44, (2010) (PubMed).
: "The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons." in: Brain : a journal of neurology, Vol. 133, Issue Pt 7, pp. 2022-31, (2010) (PubMed).
: "A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency." in: Human genetics, Vol. 127, Issue 6, pp. 721-9, (2010) (PubMed).
: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).
: "Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases." in: The British journal of ophthalmology, Vol. 94, Issue 8, pp. 1100-4, (2010) (PubMed).
: "Differential CRX and OTX2 expression in human retina and retinoblastoma." in: Journal of neurochemistry, Vol. 111, Issue 1, pp. 250-63, (2009) (PubMed).
Synonyms and alternative names related to Orthodenticle Homeobox 2
orthodenticle homeobox 2 (OTX2), orthodenticle homeobox 2 (Otx2), orthodenticle homeobox 2 (otx2), orthodenticle homeobox 2 S homeolog (otx2.S), orthodenticle homeobox 2 L homeolog (otx2.L), CPHD6, E130306E05Rik, id:ibd2915, MCOPS5, otx-2, otx2, Xotx-2, Xotx2, zgc:136535, zotx-2, zOtx2Protein level used designations for Orthodenticle Homeobox 2
- homeobox protein OTX2
- orthodenticle homolog 2
- homeobox Otx2
- etID309955.17
- homeobox protein OTX2-A
- orthodenticle 2-A
- orthodenticle-A-like protein A
- xOTX2-A
- orthodenticle homeobox protein 2
- homeobox protein OTX2-B
- orthodenticle 2-B
- orthodenticle-A-like protein B
- xOTX2-B
- LOW QUALITY PROTEIN: homeobox protein OTX2
- orthodenticle 2
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