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|Antigen||Ataxia Telangiectasia Mutated (ATM) Antibodies|
|Conjugate||This ATM antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA)
|2 references available|
|Supplier||Log in to see|
Product Details anti-ATM AntibodyTarget Details ATM Application Details Handling References for anti-ATM antibody (ABIN358435) Images
|Specificity||This antibody detects ABL pSer1981.|
|Purification||Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1981 of human ATM.|
Target Details ATMProduct Details anti-ATM Antibody Application Details Handling References for anti-ATM antibody (ABIN358435) Images back to top
|Alternative Name||ATM (ATM Antibody Abstract)|
|Background||ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1|
|Molecular Weight||350644 Da|
|Gene ID||472, 9606|
|Research Area||Cancer, DNA/RNA|
|Pathways||p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus|
Application DetailsProduct Details anti-ATM Antibody Target Details ATM Handling References for anti-ATM antibody (ABIN358435) Images back to top
ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-ATM Antibody Target Details ATM Application Details References for anti-ATM antibody (ABIN358435) Images back to top
|Buffer||PBS with 0.09 % (W/V) Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-ATM antibody (ABIN358435)Product Details anti-ATM Antibody Target Details ATM Application Details Handling Images back to top
Brunet, Gutiérrez-Enríquez, Torres, Bérez, Sanjosé, Galceran, Izquierdo, Menéndez, Gumà, Borràs: "ATM germline mutations in Spanish early-onset breast cancer patients negative for BRCA1/BRCA2 mutations." in: Clinical genetics, Vol. 73, Issue 5, pp. 465-73, 2008
Tsai, Chung, Takahashi, Xu, Hu: "Functional interaction between FOXO3a and ATM regulates DNA damage response." in: Nature cell biology, Vol. 10, Issue 4, pp. 460-7, 2008
ImagesProduct Details anti-ATM Antibody Target Details ATM Application Details Handling References for anti-ATM antibody (ABIN358435) back to top