|Antigen||Brain-Specific Angiogenesis Inhibitor 1 (BAI1) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This BAI1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-BAI1 AntibodyTarget Details BAI1 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of BAI-1 protein.(region surrounding Gln732)|
|Purification||Affinity Chromatography using epitope-specific immunogen|
Target Details BAI1Product Details anti-BAI1 Antibody Application Details Handling Images back to top
|Alternative Name||BAI1 (BAI1 Antibody Abstract)|
|Background||Brain-specific angiogenesis inhibitors, including BAI-1, BAI-2 and BAI-3, are integral membrane proteins belonging to the G protein-coupled receptor 2 family. In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines. BAI-1 protein is specifically expressed in the brain and found to localize to the cytoplasm and membrane in neuronal cells of the cerebral cortex. Reduced expression of BAI-1 in some glioblastoma cell lines and cancer tissues implicates the functional role of BAI-1 as an inhibitor of angiogenesis. The exact mechanisms underlying BAI-1 anti-angiogenetic activity are still being investigated. BAI-1 may be involved in mediating the p53 signal in suppression of glioblastoma, as well as in cell adhesion and signal transduction. Additional research shows an inverse correlation with vascularization and BAI-1 expression in both colorectal carcinomas and pulmonary adenocarcinomas.Synonyms: BAI-1, Brain-specific angiogenesis inhibitor 1|
|Molecular Weight||approx. 174 kDa|
Application DetailsProduct Details anti-BAI1 Antibody Target Details BAI1 Handling Images back to top
ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-BAI1 Antibody Target Details BAI1 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
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