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|Antigen||BCL2-Associated X Protein (BAX) Antibodies|
|Epitope||AA 179-192, pSer184 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BAX antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-BAX AntibodyTarget Details BAX Application Details Handling References for anti-BAX antibody (ABIN682843) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic phosphopeptide derived from human Bax around the phosphorylation site of Ser184|
Target Details BAXProduct Details anti-BAX Antibody Application Details Handling References for anti-BAX antibody (ABIN682843) Images back to top
|Alternative Name||Bax (BAX Antibody Abstract)|
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Subcellular location: Helical
Synonyms: BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX
|Pathways||p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded protein response|
Application DetailsProduct Details anti-BAX Antibody Target Details BAX Handling References for anti-BAX antibody (ABIN682843) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-BAX Antibody Target Details BAX Application Details References for anti-BAX antibody (ABIN682843) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-BAX antibody (ABIN682843)Product Details anti-BAX Antibody Target Details BAX Application Details Handling Images back to top
|Product cited in:||
Park, Park, Kim, Kim, Yoon, Hur: "Berberine induces mitochondrial apoptosis of EBV-transformed B cells through p53-mediated regulation of XAF1 and GADD45α." in: International journal of oncology, Vol. 49, Issue 1, pp. 411-21, 2016 Method employed by authors: Western Blotting (WB)
Daverey, Agrawal: "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Gao, Zhou, Wang, Lew, Richards, Wang: "Urocortin-2 suppression of p38-MAPK signaling as an additional mechanism for ischemic cardioprotection." in: Molecular and cellular biochemistry, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Rat (Rattus)). Further details: Sample: Lung
Park, Kim, Kim, Kim, Lee, Cho, Lee, Hur: "Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 12, pp. 6281-91, 2013 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Pereda: "[Histochemical study of the distribution of sialomucins in the oviducts and jelly coat of the oocytes of Rana pipiens. Behavior of the different layers of the coat in water]." in: Journal of embryology and experimental morphology, Vol. 24, Issue 1, pp. 1-12, 1971
ImagesProduct Details anti-BAX Antibody Target Details BAX Application Details Handling References for anti-BAX antibody (ABIN682843) back to top