anti-Human C-MYC antibody for Immunohistochemistry (Frozen Sections)

Recommended C-MYC Antibody (supplied by: Log in to see )

Antigen
V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) Antibodies
  • MRTL
  • MYCC
  • bHLHe39
  • c-Myc
  • CMYC
  • c-myc
  • C-MYC
  • LOC100136746
  • RNCMYC
  • mMyc
  • AU016757
  • Myc2
  • Niard
  • Nird
  • MYC
  • cmyc
  • zc-myc
  • c-myc II
  • myc-B
  • myc2
  • CMyc
  • CG10798
  • D-Myc
  • DM
  • DMYc
  • Dm
  • Dmel\CG10798
  • Dmyc
  • EG:BACN5I9.1
  • anon-WO03040301.171
  • bHLHe57
  • c-MYC
  • d-myc
  • dMYC
  • dMyc
  • dMyc1
  • da
  • dm
  • dm/dMyc
  • dm/myc
  • dmyc
  • dmyc1
  • l(1)G0139
  • l(1)G0354
  • l(1)G0359
  • myc
  • MYC proto-oncogene, bHLH transcription factor
  • v-myc myelocytomatosis viral oncogene homolog
  • myelocytomatosis oncogene
  • MYC proto-oncogene, bHLH transcription factor a
  • MYC proto-oncogene, bHLH transcription factor L homeolog
  • v-myc myelocytomatosis viral oncogene homolog (avian)
  • CG10798 gene product from transcript CG10798-RB
  • MYC
  • LOC100136746
  • Myc
  • myca
  • myc.L
Reactivity
Human
694
212
120
50
42
36
20
20
19
14
14
13
12
9
9
6
6
5
4
4
4
3
3
2
1
1
1
1
1
Host
Mouse
372
337
28
16
8
1
Clonality
Monoclonal
Conjugate
This C-MYC antibody is un-conjugated
47
40
39
21
18
17
17
14
13
13
13
13
13
13
12
12
12
10
5
5
5
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Fluorescence Microscopy (FM), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
477
246
229
226
226
156
151
122
91
52
18
14
14
11
10
8
6
6
2
2
1
1
Options
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Catalog No. ABIN967320
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN967319 FM IHC (fro) IHC (p) WB Mouse IgG1 Log in to see 9E10 13
1 ABIN152253 ChIP CyTOF ELISA FACS IHC IHC (fro) IHC (p) IP WB Mouse IgG2a kappa Log in to see 9E11 10
1 ABIN320077 EIA IHC (fro) IHC (p) WB Alkaline Phosphatase (AP) Mouse IgG1 C-Term Log in to see 9-00E-010 7
1 ABIN119682 FACS IHC (fro) IF FITC Mouse IgG1 C-Term Log in to see 9-00E-010 2
1 ABIN119684 EIA FACS IHC (fro) IHC (p) IP WB Mouse IgG1 C-Term Log in to see 9-00E-010 2
1 ABIN320079 EIA FACS IHC (fro) IHC (p) WB Mouse IgG1 C-Term Log in to see 9-00E-010 2
1 ABIN119683 EIA IHC (fro) IHC (p) WB HRP Mouse IgG1 C-Term Log in to see 9-00E-010 2
1 ABIN4285732 ELISA FACS ICC IF IHC (fro) IHC (p) WB Alexa Fluor 647 Mouse IgG1 kappa Log in to see 9E10 0
1 ABIN2477752 IHC (fro) FACS IHC (p) ELISA WB Mouse IgG1 Log in to see 9E10 4
1 ABIN609226 IHC (fro) FACS IHC (p) ELISA Mouse IgG1 AA 423-435 Log in to see 0
1 ABIN950700 EIA IHC (fro) IF WB FITC Chicken Ig Fraction Log in to see Polyclonal 0
1 ABIN4257090 IHC (fro) IHC (p) FITC Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0
1 ABIN4285862 IF IHC (fro) IHC (p) IP WB Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0
1 ABIN4285866 IHC (fro) IHC (p) WB Alexa Fluor 700 Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0
1 ABIN4285870 IHC (fro) IHC (p) WB DyLight 488 Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0
1 ABIN4285872 IHC (fro) IHC (p) WB DyLight 550 Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0
1 ABIN4285873 IHC (fro) IHC (p) WB DyLight 350 Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0
1 ABIN4285874 IHC (fro) IHC (p) WB DyLight 405 Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0
1 ABIN4285861 IF IHC (fro) IHC (p) IP WB Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0
1 ABIN4285865 IHC (fro) IHC (p) WB Alexa Fluor 647 Rabbit IgG AA 408-439, AA 410-419, C-Term Log in to see 9E10 0

General

Antigen V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) Antibodies
Reactivity Human
(694), (212), (120), (50), (42), (36), (20), (20), (19), (14), (14), (13), (12), (9), (9), (6), (6), (5), (4), (4), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Host Mouse
(372), (337), (28), (16), (8), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This C-MYC antibody is un-conjugated
(47), (40), (39), (21), (18), (17), (17), (14), (13), (13), (13), (13), (13), (13), (12), (12), (12), (10), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application Fluorescence Microscopy (FM), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(477), (246), (229), (226), (226), (156), (151), (122), (91), (52), (18), (14), (14), (11), (10), (8), (6), (6), (2), (2), (1), (1)
Pubmed 13 references available
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Product Details anti-C-MYC Antibody

Target Details C-MYC Application Details Handling References for anti-C-MYC antibody (ABIN967320) Images
Brand BD Pharmingen™
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human c-Myc Peptide
Clone 9E10
Isotype IgG1

Target Details C-MYC

Product Details anti-C-MYC Antibody Application Details Handling References for anti-C-MYC antibody (ABIN967320) Images back to top
Antigen
Alternative Name c-Myc (MYC Antibody Abstract)
Background The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation. C-myc migrates at 62 kDa in SDS-PAGE. Clone 9E10 recognizes human c-myc. A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.
Pathways p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus

Application Details

Product Details anti-C-MYC Antibody Target Details C-MYC Handling References for anti-C-MYC antibody (ABIN967320) Images back to top
Application Notes It is particularly useful for western blot analysis of myc-tagged recombinant proteins, and recombinant c-myc. Jurkat control lysate [50 µg (1 µg/µl)] is provided as a western blot positive control (store lysate at -20 °C). Additional control lysate is sold separately.
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-C-MYC Antibody Target Details C-MYC Application Details References for anti-C-MYC antibody (ABIN967320) Images back to top
Format Liquid
Concentration 1.0 mg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-C-MYC antibody (ABIN967320)

Product Details anti-C-MYC Antibody Target Details C-MYC Application Details Handling Images back to top
Product cited in:

Liu, Hsu, Goeddel, Karin: "Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death." in: Cell, Vol. 87, Issue 3, pp. 565-76, 1996

Lukas, Parry, Aagaard, Mann, Bartkova, Strauss, Peters, Bartek: "Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16." in: Nature, Vol. 375, Issue 6531, pp. 503-6, 1995

Royds, Sharrard, Wagner, Polacarz: "Cellular localisation of c-myc product in human colorectal epithelial neoplasia." in: The Journal of pathology, Vol. 166, Issue 3, pp. 225-33, 1992

Tosca, Linardopoulos, Malliri, Hatziolou, Nicolaidou, Spandidos: "Implication of the ras and myc oncoproteins in the pathogenesis of mycosis fungoides." in: Anticancer research, Vol. 11, Issue 4, pp. 1433-8, 1992

Blackwood, Eisenman: "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc." in: Science (New York, N.Y.), Vol. 251, Issue 4998, pp. 1211-7, 1991

DePinho, Schreiber-Agus, Alt: "myc family oncogenes in the development of normal and neoplastic cells." in: Advances in cancer research, Vol. 57, pp. 1-46, 1991

Gosney, Field, Gosney, Lye, Spandidos, Butt: "c-myc oncoprotein in bronchial carcinoma: expression in all major morphological types." in: Anticancer research, Vol. 10, Issue 3, pp. 623-8, 1990

Karayiannis, Yiagnisis, Papadimitriou, Field, Spandidos: "Evaluation of the ras and myc oncoproteins in benign gastric lesions." in: Anticancer research, Vol. 10, Issue 5A, pp. 1127-33, 1990

Spandidos, Yiagnisis, Papadimitriou, Field: "ras, c-myc and c-erbB-2 oncoproteins in human breast cancer." in: Anticancer research, Vol. 9, Issue 5, pp. 1385-93, 1990

Evan, Lewis, Ramsay, Bishop: "Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product." in: Molecular and cellular biology, Vol. 5, Issue 12, pp. 3610-6, 1986

Background publications

Campbell, Kessler, Fambrough: "The alternative carboxyl termini of avian cardiac and brain sarcoplasmic reticulum/endoplasmic reticulum Ca(2+)-ATPases are on opposite sides of the membrane." in: The Journal of biological chemistry, Vol. 267, Issue 13, pp. 9321-5, 1992

Williams, Piris, Wyllie: "Immunohistochemical demonstration of altered intracellular localization of the C-Myc oncogene product in human colorectal neoplasms." in: The Journal of pathology, Vol. 160, Issue 4, pp. 287-93, 1990

Tiniakos, Spandidos, Kakkanas, Pintzas, Pollice, Tiniakos: "Expression of ras and myc oncogenes in human hepatocellular carcinoma and non-neoplastic liver tissues." in: Anticancer research, Vol. 9, Issue 3, pp. 715-21, 1989

Images

Product Details anti-C-MYC Antibody Target Details C-MYC Application Details Handling References for anti-C-MYC antibody (ABIN967320) back to top
Supplier Images
Western Blotting (WB) image for anti-V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) antibody (ABIN967320) Western blot analysis of c-myc. Lysate from Jurkat cells was probed with anti-c-myc (...