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|Antigen||V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This C-MYC antibody is un-conjugated Alternatives|
|4 references available|
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Product Details anti-C-MYC AntibodyTarget Details C-MYC Application Details Handling References for anti-C-MYC antibody (ABIN401560) Images
|Specificity||Antibody AP09470PU detects endogenous levels of Myc only when phosphorylated at Serine 62.|
|Purification||Immunoaffinity Chromatography using epitope-specific phosphopeptide.|
|Immunogen||The antiserum was produced against synthesized phosphopeptide derived from human Myc around the phosphorylation site of Serine 62(P-L-Sp-P-S).|
Target Details C-MYCProduct Details anti-C-MYC Antibody Application Details Handling References for anti-C-MYC antibody (ABIN401560) Images back to top
|Alternative Name||C-Myc (MYC Antibody Abstract)|
|Background||The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.Synonyms: BHLHE39, Class E basic helix-loop-helix protein 39, Myc proto-oncogene protein, Transcription factor p64|
|Pathways||p53 Signaling, Cell Division Cycle, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus|
Application DetailsProduct Details anti-C-MYC Antibody Target Details C-MYC Handling References for anti-C-MYC antibody (ABIN401560) Images back to top
Immunofluorescence: 1/100approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-C-MYC Antibody Target Details C-MYC Application Details References for anti-C-MYC antibody (ABIN401560) Images back to top
|Buffer||PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Store the antibody (in aliquots) at-20 °C.|
References for anti-C-MYC antibody (ABIN401560)Product Details anti-C-MYC Antibody Target Details C-MYC Application Details Handling Images back to top
Baudino, Cleveland: "The Max network gone mad." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 691-702, 2001
Grandori, Cowley, James, Eisenman: "The Myc/Max/Mad network and the transcriptional control of cell behavior." in: Annual review of cell and developmental biology, Vol. 16, pp. 653-99, 2001
Henriksson, Lüscher: "Proteins of the Myc network: essential regulators of cell growth and differentiation." in: Advances in cancer research, Vol. 68, pp. 109-82, 1996
Blackwood, Eisenman: "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc." in: Science (New York, N.Y.), Vol. 251, Issue 4998, pp. 1211-7, 1991
ImagesProduct Details anti-C-MYC Antibody Target Details C-MYC Application Details Handling References for anti-C-MYC antibody (ABIN401560) back to top