anti-Human FAS antibody for Blocking Reagent

Recommended FAS Antibody (supplied by: Log in to see )

Antigen
Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
  • ALPS1A
  • APO-1
  • APT1
  • CD95
  • FAS1
  • FASTM
  • TNFRSF6
  • AI196731
  • APO1
  • TNFR6
  • Tnfrsf6
  • lpr
  • Fas cell surface death receptor
  • Fas (TNF receptor superfamily member 6)
  • FAS
  • Fas
  • fas
Reactivity
Human
635
113
99
13
11
10
6
6
3
3
3
3
2
1
Host
Mouse
405
300
24
5
4
3
3
Clonality
Monoclonal
Conjugate
This FAS antibody is conjugated to Alexa Fluor 647
73
63
49
30
15
8
7
5
5
5
5
4
4
4
4
4
4
2
2
2
2
2
2
1
1
1
1
1
1
Application
Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC)
331
319
209
145
103
82
61
54
52
47
23
19
12
7
6
6
5
4
4
3
3
3
2
2
2
2
2
2
1
1
1
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Pubmed
8 references available

Available images

Flow Cytometry (FACS) image for anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody (Alexa Fluor 647) (ABIN2657878)
Catalog No. ABIN2657878
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General

Antigen Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
Reactivity Human
(635), (113), (99), (13), (11), (10), (6), (6), (3), (3), (3), (3), (2), (1)
Host Mouse
(405), (300), (24), (5), (4), (3), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FAS antibody is conjugated to Alexa Fluor 647
(73), (63), (49), (30), (15), (8), (7), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC)
(331), (319), (209), (145), (103), (82), (61), (54), (52), (47), (23), (19), (12), (7), (6), (6), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 8 references available
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Product Details anti-FAS Antibody

Target Details FAS Application Details Handling References for anti-FAS antibody (ABIN2657878) Images
Cross-Reactivity Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops), Baboon, Capuchin Monkey, Chimpanzee, Marmoset, Saguinus oedipus, Cynomolgus, Pigtailed Macaque, Rhesus Monkey, Sooty mangabey (Cercocebus atys), Green Monkey (Chlorocebus sabaeus)
Purification The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
Clone DX2
Isotype IgG1 kappa

Target Details FAS

Product Details anti-FAS Antibody Application Details Handling References for anti-FAS antibody (ABIN2657878) Images back to top
Antigen
Alternative Name CD95 (FAS Antibody Abstract)
Background CD95 is a 45 kD single chain type I glycoprotein also known as Fas, APO-1, and TNFRSF6. It is a member of the TNF receptor superfamily. CD95 is expressed on T and B lymphocytes, monocytes, neutrophils, and fibroblasts. CD95 expression is upregulated by activation. The extracellular region of CD95 binds to CD178 (Fas ligand). CD178 binding to CD95 induces apoptosis and has been shown to play a role in the maintenance of peripheral tolerance.
Pathways p53 Signaling, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-FAS Antibody Target Details FAS Handling References for anti-FAS antibody (ABIN2657878) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-FAS Antibody Target Details FAS Application Details References for anti-FAS antibody (ABIN2657878) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C

References for anti-FAS antibody (ABIN2657878)

Product Details anti-FAS Antibody Target Details FAS Application Details Handling Images back to top
Background publications

Rout, Else, Yue, Connole, Exley, Kaur: "Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection." in: PLoS ONE, Vol. 5, Issue 3, pp. e9787, 2010

Xie, Li, Wang, Wu, Yang, Hsu, Smythies, Mountz: "IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 5, pp. 2289-96, 2010

Sestak, Scheiners, Wu, Hollemweguer: "Identification of anti-human CD antibodies reactive with rhesus macaque peripheral blood cells." in: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 21-6, 2007

Sergi, Kahl, Otto: "Contribution of apoptosis and apoptosis-related proteins to the malformation of the primitive intrahepatic biliary system in Meckel syndrome." in: The American journal of pathology, Vol. 156, Issue 5, pp. 1589-98, 2000

Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000

Krammer, Dhein, Walczak, Behrmann, Mariani, Matiba, Fath, Daniel, Knipping, Westendorp: "The role of APO-1-mediated apoptosis in the immune system." in: Immunological reviews, Vol. 142, pp. 175-91, 1995

Nagata, Golstein: "The Fas death factor." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1449-56, 1995

Cifone, De Maria, Roncaioli, Rippo, Azuma, Lanier, Santoni, Testi: "Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase." in: The Journal of experimental medicine, Vol. 180, Issue 4, pp. 1547-52, 1994

Images

Product Details anti-FAS Antibody Target Details FAS Application Details Handling References for anti-FAS antibody (ABIN2657878) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody (Alexa Fluor 647) (ABIN2657878) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody (Alexa Fluor 647)