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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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3.2594213 | ABIN2957616 | IHC WB | Rabbit | N-Term | Log in to see | Polyclonal | 0 | |||
3.2594213 | ABIN2957615 | WB | Rabbit | N-Term, acLys12 | Log in to see | Polyclonal | 0 | |||
3.2594213 | ABIN2957614 | IC IF IHC WB | Rabbit | Log in to see | Polyclonal | 0 | ||||
3.2594213 | ABIN4319335 | CyTOF FACS ICC IF SimWes WB | Mouse | IgG2b | Log in to see | 1F3 | 0 | |||
3.2594213 | ABIN1580427 | ICC IF IHC WB | Mouse | IgG2b | Log in to see | 1F3 | 0 | |||
1 | ABIN324443 | WB | Rabbit | IgG | AA 126-175 | Log in to see | Polyclonal | 0 | ||
1 | ABIN615020 | IHC (p) WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN203033 | WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
1 | ABIN364235 | IHC (p) WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN575653 | WB | Rabbit | AA 21-70 | Log in to see | Polyclonal | 0 | |||
1 | ABIN1735506 | IHC (p) WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN2621941 | IHC (p) WB | Rabbit | N-Term | Log in to see | Polyclonal | 0 | |||
1 | ABIN2621942 | IHC (p) WB | Rabbit | AA 121-170 | Log in to see | Polyclonal | 0 | |||
1 | ABIN4319323 | IHC (p) WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN208594 | WB | Mouse | IgG2a | Log in to see | 0 | ||||
1 | ABIN2467469 | IHC WB | Rabbit | IgG | Log in to see | Polyclonal | 0 | |||
1 | ABIN4319334 | CyTOF FACS ICC IF SimWes WB | Mouse | IgG2b | Log in to see | 1F3 | 0 | |||
1 | ABIN4961211 | FACS ICC IF WB | Alexa Fluor 405 | Mouse | IgG2b | Log in to see | 1F3 | 0 | ||
1 | ABIN4961216 | ICC IF WB | Biotin | Mouse | IgG2b | Log in to see | 1F3 | 0 | ||
1 | ABIN4961219 | FACS ICC IF WB | DyLight 680 | Mouse | IgG2b | Log in to see | 1F3 | 0 |
General |
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Antigen | High-Mobility Group Box 1 (HMGB1) Antibodies |
Reactivity | Human, Mouse (Murine), Pig (Porcine), Rat (Rattus) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This HMGB1 antibody is un-conjugated Alternatives |
Application |
Western Blotting (WB)
Alternatives
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1 reference available |
Supplier | Log in to see |
Product Details anti-HMGB1 AntibodyTarget Details HMGB1 Application Details Handling References for anti-HMGB1 antibody (ABIN1107584) Images |
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Specificity | This antibody reacts with human, mouse, rat and porcine HMGB1. |
Purification | Protein A agarose |
Immunogen | Porcine HMGB1 |
Clone | KS1 |
Isotype | IgG2a |
Target Details HMGB1Product Details anti-HMGB1 Antibody Application Details Handling References for anti-HMGB1 antibody (ABIN1107584) Images back to top |
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Antigen | |
Alternative Name | HMGB1 (HMGB1 Antibody Abstract) |
Background | High mobility group box 1 (HMGB1), named for its rapid migration properties on electrophoretic gels, is a member of the nonhistone chromatin-associated proteins. HMGB1 is translated as a 214 amino acid protein and is extensively modified posttranslationally by glycosylation, acylation, methylation, and phosphorylation. The primary structure is evolutionarily conserved, with 100 % amino acid sequence homology between rat and mouse and 99 % homology between rodent and human. Intracellular HMGB1 has previously been studied for its roles in binding DNA, stabilizing nucleosome formation, as a general transcription factor for nucleolar and mitochondrial RNA polymerases, and as a gene- and tissue-specific transcriptional regulator that can enhance transcription and/or replication. Extracellular HMGB1 has recently been implicated as a late mediator of delayed endotoxin lethality, because murine and human macrophages/monocytes release large amounts of a 29 kDa form of HMGB1 when stimulated by exposure to bacterial endotoxin.Synonyms: Amphoterin, HMG-1, HMG1, HMGB-1, High mobility group protein 1, High mobility group protein B1 |
Molecular Weight | 29 kDa |
Gene ID | 3146 |
NCBI Accession | NP_002119 |
UniProt | P09429 |
Pathways | p53 Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration |
Application DetailsProduct Details anti-HMGB1 Antibody Target Details HMGB1 Handling References for anti-HMGB1 antibody (ABIN1107584) Images back to top |
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Application Notes | Optimal working dilution should be determined by the investigator. |
Restrictions | For Research Use only |
HandlingProduct Details anti-HMGB1 Antibody Target Details HMGB1 Application Details References for anti-HMGB1 antibody (ABIN1107584) Images back to top |
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Concentration | 1.0 mg/mL |
Buffer | PBS containing 50 % glycerol, pH 7.2. Contains no preservatives. |
Preservative | Without preservative |
Handling Advice | Avoid repeated freezing and thawing. |
Storage | -20 °C |
Storage Comment | Store (in aliquots) at -20 °C. |
References for anti-HMGB1 antibody (ABIN1107584)Product Details anti-HMGB1 Antibody Target Details HMGB1 Application Details Handling Images back to top |
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Background publications |
Taguchi, Blood, del Toro, Canet, Lee, Qu, Tanji, Lu, Lalla, Fu, Hofmann, Kislinger, Ingram, Lu, Tanaka, Hori, Ogawa, Stern, Schmidt: "Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases." in: Nature, Vol. 405, Issue 6784, pp. 354-60, 2000 |
ImagesProduct Details anti-HMGB1 Antibody Target Details HMGB1 Application Details Handling References for anti-HMGB1 antibody (ABIN1107584) back to top |
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Supplier Images |